{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:27:04Z","timestamp":1787776024479,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T00:00:00Z","timestamp":1726876800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n Periodontitis is a chronic inflammatory disease that damages the supporting structures of the teeth, primarily caused by dental plaque containing Gram-negative bacteria. These bacteria trigger an inflammatory host response leading to tissue destruction.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A total of 84 patients with moderate to severe chronic periodontitis were randomly assigned to either a test group receiving 500 mg of hesperidin daily or a control group receiving a placebo both alongside scaling and root planing (SRP). Clinical parameters including the gingival index (GI), sulcus bleeding index (SBI), probing depth (PD), and clinical attachment level (CAL) were evaluated at baseline, 3 weeks, and 6 weeks. Serum C-reactive protein (CRP) levels were measured at baseline and 3 weeks to assess systemic inflammation.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 84 patients, 80 completed the study, with 60 males and 20 females. The test group showed significant reduction in serum CRP levels from baseline to 3 weeks (mean difference: 1.6300,\n P<\/jats:italic>\n < 0.001), while the control group also showed a significant decrease (mean difference: -1.2730,\n P<\/jats:italic>\n = 0.001). However, no statistically significant differences were found in clinical parameters (GI, SBI, PD, CAL) between the test and control groups at any time point. Intragroup analysis showed significant improvements in these parameters over time within both groups, indicating the effectiveness of SRP in managing clinical symptoms of periodontitis.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Hesperidin significantly reduced serum CRP levels, indicating an anti-inflammatory effect, but did not result in significant improvements in clinical parameters compared to placebo.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_902_24","type":"journal-article","created":{"date-parts":[[2024,9,21]],"date-time":"2024-09-21T13:00:10Z","timestamp":1726923610000},"page":"S3421-S3423","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Effect of Hesperidin as an Adjunct to Scaling and Root Planing on Clinical Parameters and Serum C-Reactive Protein Level in Chronic Periodontitis: A Randomized, Triple-Blind, Placebo-Controlled, Clinical Trial"],"prefix":"10.4103","volume":"16","author":[{"given":"Supriya","family":"Shirodkar","sequence":"first","affiliation":[{"name":"Department of Periodontology, Tatyasaheb Kore Dental College and Reasearch Centre, New Paragon, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Vasani","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Government Dental College and Hospital, Ahmedabad, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanu","family":"Sahney","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Sardar Patel Post Graduate Institute of Dental and Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meet","family":"Modi","sequence":"additional","affiliation":[{"name":"Dental Assistant, Metcalfe Street Dental, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salini","family":"Pattnaik","sequence":"additional","affiliation":[{"name":"Intern, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Patia, Bhubaneswar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Ravi Tejeshwar","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Periodontics, Sri Balaji Dental College, Moinabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,21]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"(Suppl 2)","key":"R2-20241227","first-page":"6","article-title":"Clinical significance of non-surgical periodontal therapy: An evidence-based perspective of scaling and root planing","volume":"29","author":"Cobb","year":"2002","journal-title":"J Clin Periodontol"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/154405910308200202","article-title":"Resolution of inflammation: A new paradigm for the pathogenesis of periodontal diseases","volume":"82","author":"Van Dyke","year":"2003","journal-title":"J Dent Res"},{"key":"R4-20241227","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/ptr.1074","article-title":"Chemistry and pharmacology of the Citrus bioflavonoid hesperidin","volume":"15","author":"Garg","year":"2001","journal-title":"Phytother Res"},{"key":"R5-20241227","first-page":"181","article-title":"Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by hesperidin in mouse macrophages","volume":"30","author":"Sakata","year":"2003","journal-title":"Gen Pharmacol"},{"key":"R6-20241227","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11130-013-0343-3","article-title":"Anti-inflammatory properties of orange juice: Possible favorable molecular and metabolic effects","volume":"68","author":"Coelho","year":"2013","journal-title":"Plant Foods Hum Nutr"},{"key":"R7-20241227","first-page":"537","article-title":"Hypouricemic and anti-inflammatory effects of the Citrus flavonoids hesperetin and naringenin in a hyperuricemic rat model","volume":"81","author":"Haidari","year":"2015","journal-title":"Planta Med"},{"key":"R8-20241227","first-page":"1173","article-title":"Effects of hesperidin supplementation on glycemic control, lipid profile, inflammatory markers, and body composition in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial","volume":"33","author":"Lorzadeh","year":"2019","journal-title":"Phytother Res"},{"key":"R9-20241227","first-page":"527","article-title":"Protective role of hesperidin against inflammation and alteration of matrix metalloproteinase-2 and -9 in benzo(a)pyrene-induced experimental lung carcinogenesis","volume":"64","author":"Vabeiryureilai","year":"2015","journal-title":"Inflam Res"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_902_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:47:12Z","timestamp":1787773632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_902_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,21]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_902_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,21]]},"assertion":[{"value":"2024-07-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-08","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}