{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:00Z","timestamp":1791288900135,"version":"4.3.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Dental caries is a multifactorial disease caused by combined effect of host, environment, and microorganism. Mutans Streptococci (MS) is the main microorganism in causing and progression of dental caries. Advances in science and technology led to attempt in managing dental caries by targeting its initiation and delaying its progress. Immunoglobulin Y has proven efficacy in reducing the colonisation of S. Mutans by affecting the adhesion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Thus the present study was undertaken to evaluate the effect of passive immunisation on S.Mutans levels in caries active children aged 8-11 yrs of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods:<\/jats:title>\n                    <jats:p>Total of 50 children were randomly divided into IgY mouthspray (Test Group) and 0.9% Saline (Control group). Saliva sample were collected and subjected to microbial examination using MSB agar at the end of 30 days of study period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Within the limitations, it can be concluded that IgY mouthspray significantly reduces the adhesion and growth of the causative agent S.Mutans in caries active children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Use of passive immunisation significantly reduces the bacterial overload and thus decreasing the dental caries in high risk children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_904_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:05:00Z","timestamp":1738235100000},"page":"S4448-S4451","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Passive Immunotherapeutics (IgY) on S. Mutans in Caries Active Children 8-11 Years of Age"],"prefix":"10.4103","volume":"16","author":[{"given":"Antarmayee","family":"Panigrahi","sequence":"first","affiliation":[{"name":"Department of Pediatric and Preventive Dentistry, Institute of Dental Sciences, SOA Deemed to be University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Pattanaik","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Pediatric and Community Dentistry, College of Dental Medicine, University of Sharjah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noorjahan","family":"Mohammad","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Preventive Dentistry, Government Dental College, Silchar, Assam, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhrajeet N.","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Patnaik","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debarchita","family":"Sarangi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/ijohs.ijohs_10_22","article-title":"Microbiological comparison of efficacy of two chewing gum on salivary levels of Streptococcus mutans count in caries active children \u2013An in vivo study","volume":"12","author":"Ramachandra","year":"2022","journal-title":"Int J Oral Health Sci"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4103\/JCD.JCD_505_18","article-title":"Probiotic Streptococcus strains in caries prevention:A systematic review","volume":"22","author":"Poorni","year":"2019","journal-title":"J Conserv Dent"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1271\/bbb.57.1077","article-title":"Oral passive immunization effect of anti-human rotavirus IgY and its behavior against proteolytic enzymes","volume":"57","author":"Hatta","year":"1993","journal-title":"Biosci Biotechnol Biochem"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000360868","article-title":"Magnetic bead-based salivary peptidome profiling analysis for severe early childhood caries","volume":"49","author":"Si","year":"2015","journal-title":"Caries Res"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"e0182712","DOI":"10.1371\/journal.pone.0182712","article-title":"Salivary peptidome profiling analysis for occurrence of new carious lesions in patients with severe early childhood caries","volume":"12","author":"Tian","year":"2017","journal-title":"PLoS One"},{"key":"R6-20250130","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.4161\/hv.23383","article-title":"Oral passive IgY-based immunotherapeutics:A novel solution for prevention and treatment of alimentary tract diseases","volume":"9","author":"Rahman","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"R7-20250130","doi-asserted-by":"crossref","first-page":"6","DOI":"10.9734\/jpri\/2020\/v32i1630643","article-title":"Effect of streptococcal IgY on quantity of streptococcus mutans in high caries risk children","volume":"32","author":"Mary","year":"2020","journal-title":"J Pharm Res Int"},{"key":"R8-20250130","first-page":"110","article-title":"The effect of mouthwash combination of immunoglobulin \u2013Y anti comD Streptococcus mutans and chitosan on the formation of Streptococcus mutans biofilm","volume":"11","author":"Batchiar","year":"2019","journal-title":"Int J Appl Pharm"},{"key":"R9-20250130","first-page":"295","article-title":"Effects of topical application of immunoglobulin yolk on mutans streptococci in dental plaque. 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