{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:40:59Z","timestamp":1790023259041,"version":"4.0.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n The pathophysiology and etiology of oral lichen planus (OLP) are still unknown, despite the fact that the condition\u2019s progression has been connected to a T-cell-based immune response. Research has focused on variables, such as oral bacteria, that may cause an autoimmune reaction with conflicting results.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n This study was conducted to evaluate the role of oral microorganisms in the pathogenesis of OLP.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n In this study, 82 formalin-fixed paraffin-embedded specimens of histopathologically confirmed cases of OLP and 20 such specimens of normal healthy subjects were obtained. Immunohistochemistry was carried out for the identification of microorganisms.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Candida albicans<\/jats:italic>\n was observed in 47.12% of OLP cases and 9.43% of healthy controls.\n Helicobacter pylori<\/jats:italic>\n was discovered in 45.21% of OLP cases and 13.46% of healthy controls. Periodontopathogenic bacteria was found in 33.14% of OLP cases and 13.45% of healthy controls. Human papillomavirus (HPV)-16 was noticed in 38.12% of OLP cases and 11.24% in the control group. HPV-18 was found in 32.43% of OLP patients and 11.43% in the control group.\n Mycoplasma salivarium<\/jats:italic>\n was found in 46.47% of OLP patients and 6.45% in control.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n It was observed that several microorganisms like\n H. pylori<\/jats:italic>\n ,\n C. albicans<\/jats:italic>\n ,\n M. salivarium<\/jats:italic>\n , periodontopathogenic bacteria, HPV-16, and HPV-18 were found to be related to OLP.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_90_24","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T06:02:05Z","timestamp":1714024925000},"page":"S2153-S2155","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of the Role of Oral Microbes in Pathogenesis of Oral Lichen Planus"],"prefix":"10.4103","volume":"16","author":[{"given":"Tarang","family":"Mehta","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Pathology and Oral Microbiology, Narsinhbhai Patel Dental College and Hospital, Sankalchand Patel University, Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Ashem","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dental College, RIMS, Imphal, Manipur, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debanti","family":"Giri","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Dr. R Ahmed Dental College and Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Jethlia","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Diagnostic Sciences, Diagnostic Division, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharti","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan 45142, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honey","family":"Lunkad","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanpal Singh","family":"Makkad","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, New Horizon Dental College and Research Institute, Sakri, Bilaspur, Chhattisgarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,24]]},"reference":[{"key":"R1-20240829","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1590\/1678-775720150203","article-title":"The presence of Helicobacter pylori in oral cavities of patients with leukoplakia and oral lichen planus","volume":"24","author":"Kazanowska-Dygdala","year":"2016","journal-title":"J Appl Oral Sci"},{"key":"R2-20240829","first-page":"e45187","article-title":"Artificial intelligence's use in the diagnosis of mouth ulcers:A systematic review","volume":"15","author":"Tiwari","year":"2023","journal-title":"Cureus"},{"key":"R3-20240829","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/jop.12568","article-title":"Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue","volume":"46","author":"Mizuki","year":"2017","journal-title":"J Oral Pathol 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association between human papillomavirus and oral lichen planus:A meta-analysis","volume":"11","author":"Ma","year":"2016","journal-title":"PLoS One"},{"key":"R8-20240829","doi-asserted-by":"crossref","first-page":"650","DOI":"10.4103\/1008-682X.160261","article-title":"The presence of human papillomavirus and Epstein-Barr virus in male Chinese lichen sclerosus patients:A single center study","volume":"18","author":"Zhang","year":"2016","journal-title":"Asian J Androl"},{"issue":"(Suppl 1)","key":"R9-20240829","doi-asserted-by":"crossref","first-page":"S820","DOI":"10.4103\/jpbs.jpbs_9_22","article-title":"Detection of human papillomavirus and its association with potentially malignant disorders and oral squamous cell carcinoma:A retrospective study","volume":"14","author":"Rathore","year":"2022","journal-title":"J Pharm Bioallied Sci"},{"key":"R10-20240829","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1111\/j.1601-0825.2010.01670.x","article-title":"Hepatitis C virus 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