{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:18Z","timestamp":1787840778712,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>Role of mast cells in the development of oral lichen planus (OLP) and oral lichenoid reactions (OLR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>The tissue slices used in this investigation were obtained from the archives of the Department of Oral Pathology and were formalin-fixed and embedded in paraffin. The sections were obtained from 40 cases of OLP that were identified by histological examination, as well as 40 cases of OLR. Twenty buccal mucosa samples were obtained from individuals who showed no mouth lesions and did not participate in any oral practices. The study samples were subjected to haematoxylin and eosin stain, as well as a specialized toluidine blue stain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In oral lichen planus, the mast cell counts were 15.25 \u00b1 2.58, which was substantially greater than in OLR (8.63 \u00b1 1.74) and normal oral mucosal tissues (1.99 \u00b1 0.58). The Kruskal\u2013Wallis test was used to compare the average number of mast cells across three groups, and the result was statistically significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). We found statistically significant results when we compared several groups using the Mann\u2013Whitney\n                      <jats:italic toggle=\"yes\">U<\/jats:italic>\n                      test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This experiment\u2019s findings point to a greater concentration of mast cells in OLP than in OLR. Because of this, we argue that counting mast cells could be an important histopathological component in pathogenesis of these lichenoid reactions and also help distinguishing OLP from OLR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_913_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:04:14Z","timestamp":1738235054000},"page":"S4755-S4759","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["To Investigate the Involvement of Mast Cells in the Pathogenesis of Oral Lichen Planus and Oral Lichenoid Reactions"],"prefix":"10.4103","volume":"16","author":[{"given":"Neeharika","family":"Soorneedi","sequence":"first","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Malla Reddy Institute of Dental Sciences, Suraram, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mekala M.","family":"Sujatha","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Radiology, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabassum","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Pediatric Dentistry and Orthodontic, Dental Assistant, Dr. Susan Blair, Bloom Pediatric Dentistry and Orthodontics, Lombard, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.G.R Pankaj","family":"Mallik","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, CKS Theja Dental College and Research, Tirupathi, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Sri Sai College of Dental Surgery, Vikarabad, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavani Nagendra","family":"Sangala","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology and Microbiology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Vakeel","sequence":"additional","affiliation":[{"name":"Department of Oral Pathology, SP Dental Craft, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1182\/blood-2007-07-102111","article-title":"Indirect involvement of allergen-captured mast cells in antigen presentation","volume":"111","author":"Kambayashi","year":"2008","journal-title":"Blood"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1600-0714.1995.tb01180.x","article-title":"Relationship between mast cell degranulation and inflammation in the oral cavity","volume":"24","author":"Walsh","year":"1995","journal-title":"J Oral Pathol Med"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1600-0714.1990.tb00866.x","article-title":"Immunopathogenesis of oral lichen planus","volume":"19","author":"Walsh","year":"1990","journal-title":"J Oral Pathol Med"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tripleo.2004.06.077","article-title":"Current controversies in oral lichen planus:report of an international consensus meeting. 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