{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:26:33Z","timestamp":1787840793381,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 5","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>This study aimed to evaluate magnetic resonance imaging (MRI) in diagnosing PIDDs in pediatric patients, analyzing imaging findings alongside clinical correlations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Method:<\/jats:title>\n                    <jats:p>A prospective cross-sectional study was conducted at a tertiary referring center in Chennai, involving 34 pediatric patients (aged \u226418 years) referred with suspected or confirmed PIDDs. MRI evaluations, clinical assessments, and laboratory findings were utilized for diagnosis. Demographic data, MRI findings, and clinical symptoms were collected and analyzed using descriptive statistics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study revealed a wide age distribution (mean age: 8.53 years), with males comprising 55.9% of participants. Acute demyelinating encephalomyelitis (ADEM) was the most common clinical presentation, with supratentorial lesions being the predominant MRI finding. Overall, MRI demonstrated high sensitivity (82.1%) and specificity (79.3%) in diagnosing PIDDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>MRI proved valuable in diagnosing pediatric inflammatory demyelinating disorders. Further research should address study limitations and explore longitudinal outcomes to enhance understanding and management of these complex neurological conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_914_24","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T11:05:05Z","timestamp":1738235105000},"page":"S4470-S4472","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Can Magnetic Resonance Imaging Diagnose Pediatric Inflammatory Demyelinating Disorders? A Tertiary Referring Center Experience in Chennai, Tamil Nadu\u2014A Cross-Sectional Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Philson J.","family":"Mukkada","sequence":"first","affiliation":[{"name":"Scans World, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teenu","family":"Franklin","sequence":"additional","affiliation":[{"name":"Scans World, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhu","family":"Radhan","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, ACS Medical College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinoth","family":"Thangam","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, ACS Medical College and Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,30]]},"reference":[{"key":"R1-20250130","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S1474-4422(06)70581-6","article-title":"Sex ratio of multiple sclerosis in Canada:A longitudinal study","volume":"5","author":"Orton","year":"2006","journal-title":"Lancet Neurol"},{"key":"R2-20250130","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S1474-4422(10)70064-8","article-title":"The changing demographic pattern of multiple sclerosis epidemiology","volume":"9","author":"Koch-Henriksen","year":"2010","journal-title":"Lancet Neurol"},{"key":"R3-20250130","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis:2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol"},{"key":"R4-20250130","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/jnnp.63.5.565","article-title":"Age at immigration to England of Asian and Caribbean immigrants and the risk of developing multiple sclerosis","volume":"63","author":"Dean","year":"1997","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R5-20250130","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S1474-4422(08)70042-5","article-title":"Environmental factors and multiple sclerosis","volume":"7","author":"Ebers","year":"2008","journal-title":"Lancet Neurol"},{"key":"R6-20250130","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1177\/1352458508096878","article-title":"Differential diagnosis of suspected multiple sclerosis:A consensus approach","volume":"14","author":"Miller","year":"2008","journal-title":"Mult Scler"},{"key":"R7-20250130","first-page":"1104","article-title":"Pediatric acquired demyelinating disorders","volume":"28","author":"Brenton","year":"2022","journal-title":"Continuum (Minneap Minn)"},{"key":"R8-20250130","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1177\/1352458512445944","article-title":"Paediatric acquired demyelinating syndromes:Incidence, clinical and magnetic resonance imaging features","volume":"19","author":"Absoud","year":"2013","journal-title":"Mult Scler"},{"key":"R9-20250130","doi-asserted-by":"crossref","first-page":"102801","DOI":"10.1016\/j.autrev.2021.102801","article-title":"Pediatric inflammatory demyelinating disorders and mimickers:How to differentiate with MRI?","volume":"20","author":"Pereira","year":"2021","journal-title":"Autoimmun Rev"},{"key":"R10-20250130","first-page":"A500.1","article-title":"1814 Pediatric demyelinating disorders - a single centre experience in a tertiary care centre, Sri Lanka","volume":"106","author":"Manori","year":"2021","journal-title":"Arch Dis Child"},{"key":"R11-20250130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1055\/s-0043-1771335","article-title":"Pediatric Acquired Demyelinating Syndrome (ADS)\u2014A proposed flowchart for imaging diagnosis","volume":"2","author":"Jeswani","year":"2023","journal-title":"Indographics"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_914_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:29:12Z","timestamp":1787837352000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_914_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":11,"journal-issue":{"issue":"Suppl 5","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_914_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}