{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:48:58Z","timestamp":1787071738715,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Conventional fluoride therapies are effective in preventing dental caries but present limitations, such as esthetic concerns and fluoride sensitivity This has led to the development of alternate agents with comparable or improved preventive potential. To systematically review and evaluate the effectiveness of alternate fluoride-based and fluoride-free interventions in the guidelines. A prevention of dental caries. This review adhered to PRISMA 2020 comprehensive literature search was conducted across five databases and grey literature sources. Studies included randomized controlled trials, in vitro experiments, and systematic reviews without meta-analysis that examined the efficacy of agents, such as \u201csilver diamine fluoride (SDF),\u201d \u201cnano-silver fluoride (NSF),\u201d grape seed extract, hydroxyapatite, casein phosphopeptide\u2013amorphous calcium phosphate (CPP-ACP), probiotics, and bioactive glasses Data were extracted regarding intervention type, mechanism, outcomes, and patient acceptability. Twenty studies met inclusion criteria. SDF was found to be noninferior to conventional sealants, while NSF offered superior esthetic outcomes with better caries arrest. Hydroxyapatite, CPP-ACP, and bioactive glasses demonstrated significant remineralization potential. Natural agents, such as theobromine and grape seed extract, showed antimicrobial and surface hardening benefits. Probiotics effectively reduced cariogenic bacterial load. Alternative caries-preventive strategies, especially NSF, CPP-ACP, and natural agents, demonstrate strong potential. Further long-term clinical trials are needed.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_926_25","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:00:10Z","timestamp":1765166410000},"page":"S17-S19","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A Systematic Review on a Variety of Alternate Fluoride Options Effective in Preventing Dental Caries"],"prefix":"10.4103","volume":"18","author":[{"given":"Kumudhati","family":"Tiwari","sequence":"first","affiliation":[{"name":"B.D.S, D.M.D, 506-1575 McCallum Rd, Abbotsford, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Annaldasula","sequence":"additional","affiliation":[{"name":"Lead Associate Dentist, Achieve Dental, 309 NE Georgia Ave, Sweetwater, TX 79556, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilu","family":"Bhadani","sequence":"additional","affiliation":[{"name":"Gentle Care Family Dental, 4237 Pelican St., High Point NC 27265, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhargavi","family":"Dasari","sequence":"additional","affiliation":[{"name":"ADS Cosmetic and Family Dentistry, 137 Grand Hill Pl, Holly Springs, NC 27540, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aarthi","family":"Duddukuri","sequence":"additional","affiliation":[{"name":"B.D.S, Kamineni Institute of Dental Sciences, Sreepuram Narketpally, Nalgonada District, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izaz","family":"Shaik","sequence":"additional","affiliation":[{"name":"Gentle Care Family Dental, 4237 Pelican St., High Point NC 27265, United States of 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demineralization and dental caries: An in vitro study","volume":"25","author":"Gon\u00e7alves","year":"2021","journal-title":"Clin Oral Investig"},{"key":"R10-20260310","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.2174\/1389201024666230405135457","article-title":"Clinical efficacy of probiotics on oral health: A systematic review of clinical trials","volume":"24","author":"Navidifar","year":"2023","journal-title":"Curr Pharm Biotechnol"},{"key":"R11-20260310","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jebdp.2017.09.003","article-title":"Calcium-based caries preventive agents: A meta-evaluation of systematic reviews and meta-analysis","volume":"18","author":"Bijle","year":"2018","journal-title":"J Evid Based Dent Pract"},{"key":"R12-20260310","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1039\/D4NR04515G","article-title":"Nanomaterial-based synergistic strategies for combating dental caries: Progress and 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