{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:54:08Z","timestamp":1787756048022,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:00:00Z","timestamp":1764979200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>Gold nanoparticles (AuNPs) and chitosan nanoparticles (CNPs) have emerged as multifunctional nanomaterials in biomedical sciences, particularly in conservative and endodontic dentistry. Thei antimicrobial, biocompatible, and regenerative properties make them promising candidates for enhancing clinical outcomes. This systematic review aimed to evaluate and synthesize the current evidence on the application of AuNPs and CNPs in endodontics and conservative dentistry. A systematic literature search was performed using PubMed, Scopus, and Web of Science databases up to April 2025. Studies focusing on the synthesis, characterization, and dental application of AuNPs and\/or CNPs were included. After applying Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 10 studies were selected and analyzed qualitatively. Most studies demonstrated strong antimicrobial efficacy of chitosan\u2013AuNP composites against biofilm-forming bacteria relevant to caries and endodontic infections. Some studies also highlighted enhanced sealing ability, siRNA delivery, drug release, and photothermal therapeutic applications. Several formulations showed high biocompatibility and regenerative potential. Gold and CNPs present significant promise in improving antimicrobial disinfection, restorative sealing, and regenerative outcomes in dentistry. However, further in vivo and clinical research is necessary to confirm their long-term safety and efficacy.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_941_25","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T04:00:06Z","timestamp":1765166406000},"page":"S20-S22","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Gold Nanoparticles and Chitosan Nanoparticles: A Systematic Review"],"prefix":"10.4103","volume":"18","author":[{"given":"Dipali","family":"Deshpande","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erkala","family":"Jyothsna","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics Crown and Bridge, Sri Sai College of Dental Surgery and Hospital, Vikarabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Gupta","sequence":"additional","affiliation":[{"name":"Oral Medicine Resident, UCSF Oral Medicine, San Francisco, California, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Singh","sequence":"additional","affiliation":[{"name":"Associate Dentist, Elica Health and Faculty, NYU Langone, Sacremento, California, United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thouseef","family":"Ch","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Malabar Dental College and Research Center, Malappuram, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heena D.","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Programme Officer, Blood Cell, Commissionerate of Health and Family Welfare, Government of Telangana, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,6]]},"reference":[{"key":"R1-20260310","doi-asserted-by":"crossref","first-page":"26582","DOI":"10.1021\/acsomega.2c02776","article-title":"New chitosan-grafted thymol coated on gold nanoparticles for control of cariogenic bacteria in the oral cavity","volume":"7","author":"Chittratan","year":"2022","journal-title":"ACS Omega"},{"key":"R2-20260310","first-page":"e75359","article-title":"Comparative evaluation of apical leakage in root canal obturation using ah plus sealer, bioceramic sealer, and bioceramic sealer incorporated with chitosan 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