{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:31:10Z","timestamp":1790721070068,"version":"4.1.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 1","license":[{"start":{"date-parts":[[2025,4,12]],"date-time":"2025-04-12T00:00:00Z","timestamp":1744416000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:p>Infertility, which affects millions worldwide, often involves male factors such as asthenozoospermia, a condition marked by reduced sperm motility. While lifestyle and environmental factors are major contributors, nutritional interventions offer an effective, non-invasive approach to treatment. This case report examines the effects of L-carnitine supplementation on male infertility in a 37-year-old patient with a six-year history of primary infertility. The patient followed a three-month protocol that included 3000 mg of L-carnitine daily, dietary changes rich in antioxidants, and lifestyle modifications. Initial semen analysis revealed significant deficiencies, including progressive motility of 15% and a sperm count of 25 million\/mL. After the intervention, notable improvements were observed: progressive motility increased to 50%, sperm count rose to 49 million\/mL, and normal morphology improved from 3% to 7%. These results highlight the role of L-carnitine in supporting sperm mitochondrial function, reducing oxidative stress, and improving key fertility parameters. The findings are consistent with existing research demonstrating the potential of L-carnitine as a treatment for male infertility. This report underscores the value of individualized nutritional and supplementation strategies in enhancing reproductive health and suggests L-carnitine as a safe and effective option for treating asthenozoospermia.<\/jats:p>","DOI":"10.4103\/jpbs.jpbs_94_25","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T08:00:13Z","timestamp":1744617613000},"page":"S1019-S1022","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Enhancing Male Fertility Through Nutrition: The Role of L-Carnitine in Asthenozoospermic Patients"],"prefix":"10.4103","volume":"17","author":[{"given":"Jafar","family":"Shaikh","sequence":"first","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akash","family":"More","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namrata","family":"Anjankar","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Nair","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanket S.","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Nawale","sequence":"additional","affiliation":[{"name":"Clinical Embryology, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,12]]},"reference":[{"key":"R2-20250513","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.2021.4788","article-title":"Diagnosis and management of infertility: A review","volume":"326","author":"Carson","year":"2021","journal-title":"JAMA"},{"key":"R4-20250513","first-page":"76","article-title":"Impact of various parameters as predictors of the success rate of in vitro fertilization","volume":"16","author":"Dabbagh Rezaeiye","year":"2022","journal-title":"Int J Fertil 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dietary antioxidant supplements in male infertility: A review","volume":"16","author":"Ghewade","year":"2024","journal-title":"Cureus"},{"key":"R14-20250513","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1016\/j.bbamcr.2016.01.023","article-title":"Carnitine transport and fatty acid oxidation","volume":"1863","author":"Longo","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"R15-20250513","first-page":"62","article-title":"[Double-blind, randomized placebo-controlled study of efficiency and safety of complex acetyl-L-carnitine, L-carnitine fumarate and alpha-lipoic acid (Spermactin Forte) for treatment of male infertility","volume":"2019","author":"Gamidov","journal-title":"Urologiia"},{"key":"R16-20250513","first-page":"76","article-title":"Effect of antioxidant supplementation containing L-carnitine on semen parameters: A prospective interventional study","volume":"25","author":"Nazari","year":"2021","journal-title":"JBRA Assist Reprod"},{"key":"R17-20250513","doi-asserted-by":"crossref","first-page":"e13267","DOI":"10.1111\/and.13267","article-title":"Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia","volume":"51","author":"Micic","year":"2019","journal-title":"Andrologia"},{"key":"R18-20250513","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1111\/andr.12191","article-title":"The role of carnitine in male infertility","volume":"4","author":"Mongioi","year":"2016","journal-title":"Andrology"},{"key":"R19-20250513","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1530\/RAF-20-0037","article-title":"l-carnitine and l-acetylcarnitine supplementation for idiopathic male infertility","volume":"1","author":"Khaw","year":"2020","journal-title":"Reprod Fertil"}],"container-title":["Journal of Pharmacy and Bioallied 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