{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:40:46Z","timestamp":1790116846337,"version":"4.0.1"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"\n A\n BSTRACT<\/jats:sc>\n <\/jats:title>\n \n Background:<\/jats:title>\n There is a growing correlation between periodontal disease, a common inflammatory disorder that affects the tissues supporting the teeth, and several systemic diseases.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n Two hundred patients from a tertiary care hospital, ages 50\u201375, participated in this cross-sectional research. The subjects were split up into four groups: 50 individuals with rheumatoid arthritis, 50 with Alzheimer\u2019s disease, 50 with Parkinson\u2019s disease, and 50 with periodontal disease. To evaluate periodontal condition, including clinical attachment loss and pocket depth, thorough oral exams were performed. Measurements were made of serum biomarkers for inflammation, such as interleukin-6 (IL-6) and C-reactive protein (CRP). Multivariate regression models were used to examine correlations between the severity of periodontal disease and the underlying systemic diseases.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n In all groups, there were significant relationships between higher levels of indicators of systemic inflammation and the severity of periodontal disease. In comparison to healthy controls (CRP mean value: 2.1 mg\/L; IL-6 mean value: 6.4 pg\/mL), participants with periodontal disease had higher mean levels of CRP (5.6 mg\/L) and IL-6 (mean value: 12.8 pg\/mL). Furthermore, compared to those with rheumatoid arthritis, those with Alzheimer\u2019s and Parkinson\u2019s disorders showed higher levels of pocket depth and periodontal attachment loss.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n In conclusion, the results point to a possible connection between systemic diseases such rheumatoid arthritis, Parkinson\u2019s disease, and Alzheimer\u2019s.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_975_24","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:02:54Z","timestamp":1731481374000},"page":"S3775-S3777","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Exploring the Link between Periodontal Disease and Systemic Conditions: Implications for Alzheimer\u2019s, Parkinson\u2019s, and Rheumatoid Arthritis"],"prefix":"10.4103","volume":"16","author":[{"family":"Kanimozhi","sequence":"first","affiliation":[{"name":"Assistant Professor, DEIC, (District Early Intervention Centre) Government Kilpauk Medical College and Hospital, Kilpauk, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Aishwarya","sequence":"additional","affiliation":[{"name":"BDS, Government Dental College and Hospital, Vijayawada, Andhra Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweta","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Theerthanker Mahaveer Dental College and Research Centre, Delhi Moradabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajith A.","family":"Chandy","sequence":"additional","affiliation":[{"name":"BDS (JSS Dental College and Hospital) Diploma in Dental Hygiene, Confederation College, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramyashri","family":"Muralikrishna","sequence":"additional","affiliation":[{"name":"MBBS, 3year Medical Student, KIMS College, Banashankari, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Shinkre","sequence":"additional","affiliation":[{"name":"Department of Public Health Dentistry, Research Consultant, Central Research Wing, K.L.E Society\u2019s Institute of Dental Sciences, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1038\/nrdp.2017.38","article-title":"Periodontal diseases","volume":"3","author":"Kinane","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"(4 Suppl)","key":"R2-20241227","first-page":"S24","article-title":"Periodontitis and atherosclerotic cardiovascular disease: Consensus report of the Joint EFP\/AAP Workshop on periodontitis and systemic diseases","volume":"84","author":"Tonetti","year":"2013","journal-title":"J Periodontol"},{"key":"R3-20241227","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1177\/0022034512457373","article-title":"Prevalence of periodontitis in adults in the United States: 2009 and 2010","volume":"91","author":"Eke","year":"2012","journal-title":"J Dent Res"},{"issue":"(Suppl 14)","key":"R4-20241227","first-page":"S1","article-title":"Infection and inflammatory mechanisms","volume":"40","author":"Van Dyke","year":"2013","journal-title":"J Clin Periodontol"},{"key":"R5-20241227","doi-asserted-by":"crossref","first-page":"eaau3333","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci 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Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_975_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:06Z","timestamp":1787837106000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_975_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":8,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_975_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]},"assertion":[{"value":"2024-08-08","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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