{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:45Z","timestamp":1787840565527,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 4","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>\n                    A\n                    <jats:sc>BSTRACT<\/jats:sc>\n                  <\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dental caries remains a prevalent chronic condition affecting individuals worldwide, particularly children. Traditional fluoride varnishes have long been employed in caries prevention due to their ability to enhance enamel remineralization and reduce demineralization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A randomized controlled trial was conducted involving 120 participants aged 6\u201312 years with a high risk of dental caries. The participants were divided into two groups: one receiving nanosilver varnish and the other receiving traditional fluoride varnish. Each varnish was applied bi-weekly for six months. Salivary samples were collected at baseline, three months, and six months to measure bacterial counts, focusing on Streptococcus mutans. The data were analyzed using ANOVA to assess differences between the groups over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>At baseline, both groups exhibited similar levels of Streptococcus mutans (P &gt; 0.05). After three months, the nanosilver group showed a significant reduction in bacterial counts (mean reduction of 45%, P &lt; 0.01), compared to a 30% reduction in the fluoride varnish group (P &lt; 0.05). At six months, the nanosilver group maintained a 55% reduction, whereas the fluoride group showed a 40% reduction. The difference between the groups at six months was statistically significant (P &lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Nanosilver varnish demonstrated superior antibacterial efficacy compared to traditional fluoride varnish in reducing Streptococcus mutans levels over six months. These findings suggest that nanosilver could serve as a valuable alternative or adjunct to fluoride varnish in caries prevention strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jpbs.jpbs_997_24","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T07:04:32Z","timestamp":1731481472000},"page":"S3485-S3487","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparing the Antibacterial Efficacy of Nanosilver vs Traditional Fluoride Varnishes in Caries Prevention"],"prefix":"10.4103","volume":"16","author":[{"given":"Jagriti","family":"Kushwah","sequence":"first","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Institute of Dental Education and Advance Studies, Gwalior, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akshata","family":"Ron","sequence":"additional","affiliation":[{"name":"Department of Dentistry, KLE JGMM Medical College, Hubballi, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Khullar","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, All India Institute of Medical Sciences, Vijaypur, Jammu, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pedodontic and Preventive Dentistry, Teerthanker Mahaveer Dental College and Research Centre, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasthuripriya","family":"Kuppusamy","sequence":"additional","affiliation":[{"name":"Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prateek J.","family":"Pachore","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Sankalchand Patel Vidyadham, Ambaji Gandhinagar Link Road, Near Kamana Char Rasta, Visnagar, North Gujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,11,13]]},"reference":[{"key":"R1-20241227","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biotechadv.2008.09.002","article-title":"Silver nanoparticles as a new generation of antimicrobials","volume":"27","author":"Rai","year":"2009","journal-title":"Biotechnol Adv"},{"key":"R2-20241227","first-page":"759","article-title":"Antibacterial and remineralizing orthodontic adhesive containing quaternary ammonium resin monomer and amorphous calcium phosphate nanoparticles","volume":"28","author":"Zhang","year":"2013","journal-title":"J 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nanoparticles","volume":"3","author":"Kim","year":"2007","journal-title":"Nanomedicine"},{"key":"R7-20241227","first-page":"635","article-title":"Anti-bacterial effects of silver nano-particles on the growth of Streptococcus mutans and Streptococcus sobrinus","volume":"26","author":"Ahmed","year":"2016","journal-title":"J Coll Physicians Surg Pak"},{"key":"R8-20241227","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.nano.2008.04.005","article-title":"The antimicrobial sensitivity of Streptococcus mutans to nanoparticles of silver, zinc oxide, and gold","volume":"4","author":"Hernandez-Sierra","year":"2008","journal-title":"Nanomedicine"},{"key":"R9-20241227","first-page":"104715","article-title":"Silver nanoparticles enhance the caries prevention properties of fluoride varnish by inhibiting Streptococcus mutans growth","volume":"113","author":"Chen","year":"2020","journal-title":"Arch Oral Biol"}],"container-title":["Journal of Pharmacy and Bioallied Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_997_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:10Z","timestamp":1787837110000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jpbs.jpbs_997_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,13]]},"references-count":9,"journal-issue":{"issue":"Suppl 4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jpbs.jpbs_997_24","relation":{},"ISSN":["0976-4879","0975-7406"],"issn-type":[{"value":"0976-4879","type":"print"},{"value":"0975-7406","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,13]]},"assertion":[{"value":"2024-08-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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