{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:25:04Z","timestamp":1787772304784,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n                    <jats:title>Backgrounds:<\/jats:title>\n                    <jats:p>To determine the average cutoff values of serum-free and total testosterone (FT, TT) and dehydroepiandrosterone sulfate (DHEAS) among healthy premenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Participants were women aged 18\u201355 years without signs and symptoms of hyperandrogenism (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 489). Participants if Ferriman\u2013Gallwey (FG) scores between 6 and 8 were considered a group located in the upper spectrum related to the normal hirsutism score (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 30). DHEAS, TT, and FT levels were compared between different populations. Upper limits of 97.5 and 95 and lower limits of 5 and 2.5 percentiles were calculated to provide the reference intervals for DHEA, TT, and FT in the total sample and in the population with FG 6\u20138.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the total population, the mean \u00b1 standard deviation (SD) serum FT, TT, and DHEAS levels were 1.40 \u00b1 0.63 pg\/mL, 0.42 \u00b1 0.17 ng\/mL, and 1.5 \u00b1 0.97 \u00b5g\/ml, respectively. The cutoff values of FT at 1.35 and TT at 0.49 were obtained for differentiating the patients with FG 6\u20138 scores from the normal population, with the corresponding specificity of 0.60, the sensitivity of 0.67, and area under the ROC curve (AUC) (confidence interval 95%) of 0.63 (0.52\u20130.73),\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.01 and 0.68 (0.58\u20130.78)\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our study, the mean \u00b1 SD serum FT level was 1.40 \u00b1 0.63 pg\/mL, the TT level was 0.42 \u00b1 0.17 ng\/mL, and the DHEAS level was 1.5 \u00b1 0.97 \u00b5g\/ml, in premenopausal women between 18 and 49 years of age. Furthermore, in a population with FG 6\u20138 score, a cutoff value of FT at 1.35 and TT at 0.49 was obtained. Although the irregular menstrual cycle did not change the reference range when compared with the normal group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jrms.jrms_100_22","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T11:09:07Z","timestamp":1716462547000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Reference range of testosterone and dehydroepiandrosterone sulfate levels in women during reproductive age in the Iranian population"],"prefix":"10.4103","volume":"28","author":[{"given":"Rokhsareh","family":"Meamar","sequence":"first","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awat","family":"Feizi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Aminorroaya","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Amini","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Iraj","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Heidarpour","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,9]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1210\/jc.2005-2596","article-title":"Effects of testosterone replacement in androgen-deficient women with hypopituitarism: A randomized, double-blind, placebo-controlled study","volume":"91","author":"Miller","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1001\/archinte.166.13.1380","article-title":"Low testosterone levels and the risk of anemia in older men and women","volume":"166","author":"Ferrucci","year":"2006","journal-title":"Arch Intern Med"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1210\/jc.2006-0588","article-title":"Androgen therapy induces muscle protein anabolism in older women","volume":"91","author":"Sheffield-Moore","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1210\/endo.142.11.8547","article-title":"Minireview: Aromatase and the regulation of estrogen biosynthesis \u2013 Some new perspectives","volume":"142","author":"Simpson","year":"2001","journal-title":"Endocrinology"},{"key":"R5-20240830","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0039-128X(98)00007-5","article-title":"DHEA and the intracrine formation of androgens and estrogens in peripheral target tissues: Its role during aging","volume":"63","author":"Labrie","year":"1998","journal-title":"Steroids"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/000456329002700606","article-title":"Basal serum dehydroepiandrosterone sulphate concentration does not predict the cortisol response to provocative testing","volume":"27","author":"Littley","year":"1990","journal-title":"Ann Clin Biochem"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"322","DOI":"10.4158\/EP.5.6.322","article-title":"Serum testosterone levels and reference ranges in reproductive-age women","volume":"5","author":"Ayala","year":"1999","journal-title":"Endocr Pract"},{"key":"R8-20240830","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1093\/aje\/153.3.256","article-title":"Testosterone concentrations in women aged 25-50 years: Associations with lifestyle, body composition, and ovarian status","volume":"153","author":"Sowers","year":"2001","journal-title":"Am J Epidemiol"},{"key":"R9-20240830","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/sj.ijir.3901178","article-title":"Serum androgen levels in healthy premenopausal women with and without sexual dysfunction: Part A. 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