{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:57Z","timestamp":1787840577647,"version":"build-2784847793"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"\n Background:<\/jats:title>\n The link between autoimmune thyroid diseases and Vitamin D deficiency has been reported. However, there are controversies in this regard. We conducted a double-blind randomized placebo-controlled clinical trial to investigate the effect of Vitamin D deficiency treatment on thyroid function and autoimmunity marker (thyroid peroxidase antibody [TPO-Ab]) in patients with Hashimoto's thyroiditis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n Fifty-six patients with Hashimoto's thyroiditis and Vitamin D deficiency (25-hydroxyvitamin D level \u226420 ng\/mL) were randomly allocated into two groups to receive Vitamin D (50000 IU\/week, orally) or placebo for 12 weeks, as Vitamin D-treated (\n n<\/jats:italic>\n = 30) and control (\n n<\/jats:italic>\n = 26) groups, respectively. TPO-Ab, thyroid-stimulating hormone (TSH), parathormone, calcium, albumin, and creatinine concentrations were compared before and after trial between and within groups. The data were presented as mean (standard error [SE]) and analyzed by appropriate tests.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Mean (SE) of Vitamin D was increased in Vitamin D-treated group (45.5 [1.8] ng\/mL vs. 12.7 [0.7] ng\/mL,\n P<\/jats:italic>\n = 0.01). Mean (SE) of TPO-Ab did not significantly change in both groups (734 [102.93] IU\/mL vs. 820.25 [98.92] IU\/mL,\n P<\/jats:italic>\n = 0.14 in Vitamin D-treated and 750.03 [108.7] [IU\/mL] vs. 838.07 [99.4] [IU\/mL] in placebo-treated group,\n P<\/jats:italic>\n = 0.15). Mean (SE) of TSH was not changed in both groups after trial,\n P<\/jats:italic>\n = 0.4 and\n P<\/jats:italic>\n = 0.15 for Vitamin D-treated and control groups, respectively. No significant difference was observed between two study groups in none studied variables (\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Vitamin D treatment in Vitamin D deficient patients with Hashimoto's thyroiditis could not have significant effect on thyroid function and autoimmunity.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrms.jrms_1048_16","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T06:40:46Z","timestamp":1506408046000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":31,"title":["Effect of Vitamin D deficiency treatment on thyroid function and autoimmunity markers in Hashimoto's thyroiditis: A double-blind randomized placebo-controlled clinical trial"],"prefix":"10.4103","volume":"22","author":[{"given":"Parichehr","family":"Vahabi Anaraki","sequence":"first","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Aminorroaya","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massoud","family":"Amini","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Momeni","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awat","family":"Feizi","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijan","family":"Iraj","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azamosadat","family":"Tabatabaei","sequence":"additional","affiliation":[{"name":"Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,9,26]]},"reference":[{"key":"R2-20250827","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1081\/IPH-120014721","article-title":"Human neutrophils express messenger RNA of Vitamin D receptor and respond to 1alpha, 25-dihydroxyvitamin D3","volume":"24","author":"Takahashi","year":"2002","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"R3-20250827","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1126\/science.6310748","article-title":"1,25-dihydroxyvitamin D3 receptors in human leukocytes","volume":"221","author":"Provvedini","year":"1983","journal-title":"Science"},{"key":"R4-20250827","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nri2378","article-title":"Vitamin effects on the immune system: Vitamins A and D take centre stage","volume":"8","author":"Mora","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"R5-20250827","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nri3045","article-title":"Modulation of the immune system by UV radiation: More than just the effects of Vitamin D?","volume":"11","author":"Hart","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"R6-20250827","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.rdc.2012.03.013","article-title":"Vitamin D: Extraskeletal health","volume":"38","author":"Holick","year":"2012","journal-title":"Rheum Dis Clin North Am"},{"key":"R7-20250827","doi-asserted-by":"crossref","first-page":"504","DOI":"10.2337\/diabetes.49.3.504","article-title":"Vitamin D receptor allele combinations influence genetic susceptibility to type 1 diabetes in Germans","volume":"49","author":"Pani","year":"2000","journal-title":"Diabetes"},{"key":"R8-20250827","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1530\/eje.0.1470635","article-title":"Vitamin D receptor genotype is associated with Addison's disease","volume":"147","author":"Pani","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"R9-20250827","doi-asserted-by":"crossref","first-page":"371","DOI":"10.18388\/abp.2008_3085","article-title":"Association analysis of Vitamin D receptor gene polymorphisms with bone mineral density in young women with Graves\u2019 disease","volume":"55","author":"Horst-Sikorska","year":"2008","journal-title":"Acta Biochim Pol"},{"key":"R10-20250827","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1744-313X.2008.00748.x","article-title":"Association of vitamin D receptor gene 3\u2019-variants with Hashimoto's thyroiditis in the Croatian population","volume":"35","author":"Stefanic","year":"2008","journal-title":"Int J Immunogenet"},{"key":"R11-20250827","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2265.2004.02015.x","article-title":"Lack of association of the Vitamin D receptor gene with Graves\u2019 disease in UK Caucasians","volume":"60","author":"Collins","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R12-20250827","doi-asserted-by":"crossref","first-page":"1080S","DOI":"10.1093\/ajcn\/87.4.1080S","article-title":"Vitamin D deficiency: A worldwide problem with health consequences","volume":"87","author":"Holick","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"R13-20250827","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1212\/01.WNL.0000101723.79681.38","article-title":"Vitamin D intake and incidence of multiple sclerosis","volume":"62","author":"Munger","year":"2004","journal-title":"Neurology"},{"key":"R14-20250827","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/NEN.0b013e31827f4fcc","article-title":"Expression of Vitamin D receptor and metabolizing enzymes in multiple sclerosis-affected brain tissue","volume":"72","author":"Smolders","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"key":"R15-20250827","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ecl.2010.02.013","article-title":"Vitamin D and diabetes","volume":"39","author":"Takiishi","year":"2010","journal-title":"Endocrinol Metab Clin North Am"},{"key":"R16-20250827","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1136\/adc.2007.128579","article-title":"Vitamin D supplementation in early childhood and risk of type 1 diabetes: A systematic review and meta-analysis","volume":"93","author":"Zipitis","year":"2008","journal-title":"Arch Dis Child"},{"key":"R17-20250827","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s001250051112","article-title":"Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. The EURODIAB Substudy Study Group","volume":"42","year":"1999","journal-title":"Diabetologia"},{"key":"R18-20250827","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s12026-014-8579-z","article-title":"Vitamin D and autoimmune thyroid diseases: Facts and unresolved questions","volume":"61","author":"Bizzaro","year":"2015","journal-title":"Immunol Res"},{"key":"R19-20250827","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.autrev.2012.07.007","article-title":"Can supplementation with Vitamin D reduce the risk or modify the course of autoimmune diseases? A systematic review of the literature","volume":"12","author":"Antico","year":"2012","journal-title":"Autoimmun Rev"},{"key":"R20-20250827","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3349\/ymj.2014.55.2.476","article-title":"Low serum Vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis","volume":"55","author":"Shin","year":"2014","journal-title":"Yonsei Med J"},{"key":"R21-20250827","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4158\/EP12376.OR","article-title":"The association between severity of Vitamin D deficiency and Hashimoto's thyroiditis","volume":"19","author":"Bozkurt","year":"2013","journal-title":"Endocr Pract"},{"key":"R22-20250827","first-page":"267","article-title":"Vitamin D deficiency and its association with thyroid disease","volume":"7","author":"Mackawy","year":"2013","journal-title":"Int J Health Sci (Qassim)"},{"key":"R23-20250827","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1530\/EJE-12-0048","article-title":"Vitamin D deficiency is not associated with early stages of thyroid autoimmunity","volume":"167","author":"Effraimidis","year":"2012","journal-title":"Eur J Endocrinol"},{"key":"R24-20250827","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.nutres.2015.05.019","article-title":"Vitamin D intake associates with insulin resistance in type 2 diabetes, but not in latent autoimmune diabetes in adults","volume":"35","author":"Cardoso-S\u00e1nchez","year":"2015","journal-title":"Nutr Res"},{"key":"R25-20250827","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/cmi.2010.73","article-title":"Vitamin D and autoimmune thyroid diseases","volume":"8","author":"Kivity","year":"2011","journal-title":"Cell Mol Immunol"},{"key":"R26-20250827","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/s40618-014-0064-y","article-title":"The association between serum 25OHD levels and hypothyroid Hashimoto's thyroiditis","volume":"37","author":"Mansournia","year":"2014","journal-title":"J Endocrinol Invest"},{"key":"R27-20250827","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/thy.2009.0200","article-title":"Relative Vitamin D insufficiency in Hashimoto's thyroiditis","volume":"21","author":"Tamer","year":"2011","journal-title":"Thyroid"},{"key":"R28-20250827","doi-asserted-by":"crossref","first-page":"239815","DOI":"10.1155\/2015\/239815","article-title":"Isolated Vitamin D deficiency is not associated with nonthyroidal illness syndrome, but with thyroid autoimmunity","volume":"2015","author":"Arslan","year":"2015","journal-title":"ScientificWorldJournal"},{"key":"R29-20250827","doi-asserted-by":"crossref","first-page":"493","DOI":"10.5114\/ceji.2014.47735","article-title":"Vitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis","volume":"39","author":"Unal","year":"2014","journal-title":"Cent Eur J Immunol"},{"key":"R30-20250827","first-page":"85","article-title":"Effects of Vitamin D treatment on thyroid autoimmunity","volume":"21","author":"Simsek","year":"2016","journal-title":"J Res Med Sci"},{"key":"R31-20250827","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.autrev.2014.10.008","article-title":"Is Vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?","volume":"14","author":"D\u2019Aurizio","year":"2015","journal-title":"Autoimmun Rev"},{"key":"R32-20250827","doi-asserted-by":"crossref","first-page":"e1639","DOI":"10.1097\/MD.0000000000001639","article-title":"Lower Serum 25-Hydroxyvitamin D level is associated with 3 types of autoimmune thyroid diseases","volume":"94","author":"Ma","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"R33-20250827","doi-asserted-by":"crossref","first-page":"44","DOI":"10.11648\/j.ajim.20140203.12","article-title":"Frequency of Hashimoto's thyroiditis in women with Vitamin D deficiency: A cross sectional study","volume":"2","author":"Saler","year":"2014","journal-title":"Am J Internal Med"},{"key":"R34-20250827","first-page":"5","article-title":"Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients","volume":"22","author":"Anaraki","year":"2017","journal-title":"J Res Med Sci"}],"container-title":["Journal of Research in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01222967-201722000-00103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:21Z","timestamp":1787837121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01222967-201722000-00103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.4103\/jrms.jrms_1048_16","relation":{},"ISSN":["1735-1995","1735-7136"],"issn-type":[{"value":"1735-1995","type":"print"},{"value":"1735-7136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2017-01-16","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-06-20","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}