{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:57Z","timestamp":1787840577965,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Rapid and accurate identification and evaluation of antifungal susceptibility pattern of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      isolates are crucial to determine suitable antifungal drugs for the treatment of patients with vulvovaginitis candidiasis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Vaginal samples were collected from 150 women with suspicious vaginal candidiasis, and then cultured on Sabouraoud's Dextrose Agar with chloramphenicol to isolate\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species. After identification of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      isolates using polymerase chain reaction-restriction fragment length polymorphism technique, antifungal susceptibility testing of four azolic antifungal drugs was carried out using broth microdilution method according to the CLSI M27-A3.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species were isolated from eighty suspected patients (61.79%). The most common pathogen was\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      (63.75%). Resistance to fluconazole and ketoconazole was observed in 27.5% and 23.75% of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      isolates, respectively, and only 2% of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      isolates were resistant to miconazole. Interestingly, resistance to fluconazole in\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      was more than other\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results indicated that therapy should be selected according to the antifungal susceptibility tests for the prevention of treatment failure and miconazole therapy can be considered as the best therapeutic choice in the management of vulvovaginitis.<\/jats:p>\n                  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