{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:59:46Z","timestamp":1787169586136,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Cognitive dysfunction presents one of the chief causes of postoperative morbidity. Melatonin as a neurohormone can improve neurocognitive functioning and sleep disorders. We evaluated the effect of melatonin on the postoperative cognitive function of patients undergoing coronary artery bypass grafting (CABG).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A triple-blind randomized-controlled trial was conducted on 66 CABG candidates in Namazee Hospital (Shiraz, Iran). Patients were assigned equally into two groups receiving melatonin 10 mg or a placebo daily for 4 weeks before surgery and 2 days after surgery in the intensive care unit. The Mini-Mental State Examination (MMSE), Tower of London (ToL), and Wechsler Adults Intelligence Scale-Revised (WAIS-R) cognitive function tests were performed in both groups 4 weeks before surgery (time point 1), 2 days after surgery (time point 2), and 6 weeks after initial administration of melatonin (time point 3).<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The mean change score (time point 3-time point 1) differed significantly between the two groups in the MMSE (\n P<\/jats:italic>\n \u2264 0.001), ToL total score (\n P<\/jats:italic>\n = 0.001), and WAIS-R general IQ (\n P<\/jats:italic>\n \u2264 0.001), picture completion (\n P<\/jats:italic>\n \u2264 0.001), vocabulary (\n P<\/jats:italic>\n = 0.024), and digit span (\n P<\/jats:italic>\n = 0.01). On the other hand, no significant differences were detected in the WAIS-R block design, ToL total time delay, ToL total lab, and ToL total result scores.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The MMSE and WAIS-R tests revealed that melatonin might have prophylactic effects against postoperative cognitive disturbance in patients undergoing elective CABG.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrms.jrms_118_21","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T12:14:29Z","timestamp":1678968869000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The effect of melatonin on cognitive functions following coronary artery bypass grafting: A triple-blind randomized-controlled trial"],"prefix":"10.4103","volume":"28","author":[{"given":"Reza","family":"Jouybar","sequence":"first","affiliation":[{"name":"Anesthesiology and Critical Care Research Center, Shiraz 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