{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:31:44Z","timestamp":1787927504091,"version":"build-2784847793"},"reference-count":82,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:p>\n                    Orofacial clefts (OFCs) are among the most common congenital anomalies, arising from a complex interplay of genetic and environmental factors that disrupt the precisely coordinated processes of craniofacial development. This review collects current evidence on the role of the chromodomain helicase DNA-binding (CHD) family of ATP-dependent chromatin remodelers in OFC etiology. We highlight the functions of the nine mammalian CHD proteins (CHD1\u2013CHD9) during palatogenesis. There is strong evidence that mutations in\n                    <jats:italic toggle=\"yes\">CHD1, CHD3, CHD4<\/jats:italic>\n                    , and\n                    <jats:italic toggle=\"yes\">CHD7<\/jats:italic>\n                    are directly causative for OFCs, frequently through alterations in critical developmental signaling pathways, including bone morphogenetic protein, wingless-related integration site, and retinoic acid, leading to disrupted cranial neural crest cell specification, migration, and differentiation. This review concludes that a specific subset of CHD proteins acts as essential epigenetic regulators of gene programs critical for palate formation. Understanding their distinct and overlapping functions provides novel insights into OFC pathogenesis.\n                  <\/jats:p>","DOI":"10.4103\/jrms.jrms_118_26","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:07:31Z","timestamp":1787926051000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Chromodomain helicase DNA-binding proteins and orofacial cleft"],"prefix":"10.4103","volume":"31","author":[{"given":"Mehran","family":"Dehghanian","sequence":"first","affiliation":[{"name":"Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Craniofacial and Cleft Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Craniofacial and Cleft Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Abdali","sequence":"additional","affiliation":[{"name":"Craniofacial and Cleft Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Department of Surgery, School of Medicine, Plastic and Reconstructive Surgery, Craniofacial and Cleft Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayereh","family":"Nouri","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Karyogen Lab, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kazemi","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Reproductive Sciences and Sexual Health Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5]]},"reference":[{"key":"R1-20260828","doi-asserted-by":"crossref","first-page":"2215540","DOI":"10.1080\/07853890.2023.2215540","article-title":"Global, regional and national burden of orofacial clefts from 1990 to 2019: An analysis of the Global Burden of Disease Study 2019","volume":"55","author":"Wang","year":"2023","journal-title":"Ann Med"},{"key":"R2-20260828","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3390\/genes14081603","article-title":"Orofacial clefts: Genetics of 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