{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:23:12Z","timestamp":1787847792886,"version":"build-2784847793"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n Background:<\/jats:title>\n We investigated the impact of a home-based exercise intervention (HBEI) on cardiac biomarkers, liver enzymes, cardiometabolic outcomes, and health-related quality of life (HRQL) in clinically stable patients after coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n The study was a nonrandomized clinical trial conducted in Tehran, Iran, from July 2019 to January 2020. Forty cardiac patients (after the cardiac intervention, CABG,\n n<\/jats:italic>\n = 32; PCI,\n n<\/jats:italic>\n = 8) were recruited based on the study inclusion criteria and were allocated consecutively to one of two groups: (1) HBEI (\n n<\/jats:italic>\n = 18) and (2) conventional center-based exercise program (CBEP,\n n<\/jats:italic>\n = 22). The CBEP group performed the routine exercise program of Sadr Heart Clinic, and the HBEI group performed a home-based remotely monitored exercise protocol, both three times per week, for 8 weeks. The following variables were assessed before and after the intervention: anthropometric measures; blood pressure; lipid profile; cardiac biomarkers including cardiac troponin I, creatine kinase, and total and Mb isozyme; liver enzymes including aspartate aminotransferase and alanine aminotransferase; creatinine; urea; exercise capacity; and HRQL.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In comparison with pretest in both CBEP and HBEI groups, a significant improvement in all of the measured variables (\n P<\/jats:italic>\n < 0.05), but not in ejection fraction was observed (\n P<\/jats:italic>\n > 0.05). Moreover, in the CBEP group, a more significant decline in troponin I levels (\n P<\/jats:italic>\n = 0.03), and in the HBEI group, a greater reduction in weight (\n P<\/jats:italic>\n = 0.01) and body mass index (\n P<\/jats:italic>\n = 0.04) occurred.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The findings suggest that a properly designed and monitored HBEI may be as effective as conventional center-based cardiac rehabilitation (CR) exercise programs and should be encouraged in those cardiac patients who are unable or uninterested in conventional center-based CR exercise programs.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrms.jrms_25_20","type":"journal-article","created":{"date-parts":[[2021,1,28]],"date-time":"2021-01-28T05:09:38Z","timestamp":1611810578000},"page":"5","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Effects of a home based exercise intervention on cardiac biomarkers, 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