{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:28:06Z","timestamp":1787840886594,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Background:<\/jats:title>\n \n Migraine is a common disorder which affects quality of life. There has been an increasing interest for discovering the association of gastrointestinal (GI) disorders with migraine during past years. This study aims to evaluate the association of\n Helicobacter pylori<\/jats:italic>\n contamination, gastroesophageal reflux disease (GERD), gastric ulcer (GU), and duodenal ulcer (DU) with migraine in patients who underwent upper GI endoscopy due to refractory dyspepsia.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n In this observational cross-sectional study, 341 dyspeptic patients who underwent upper GI endoscopy in Shahid Beheshti Hospital, Qom, Iran, included during 2016\u20132018. A checklist was used for collecting demographics, symptoms, and results from endoscopy and\n H. pylori<\/jats:italic>\n testing. Diagnosis of migraine was made according to the International Headache Society criteria in patients who had headache. Data were analyzed using Chi-square and independent samples\n t<\/jats:italic>\n -tests in SPSS 16 (SPSS Inc., Chicago, IL, USA) with\n P<\/jats:italic>\n < 0.05 as significance level.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among 341 patients, 141 (% 41.3) were male and 200 (58.7%) were female. 149 (43.7%) patients were diagnosed with migraine, from which 48 (32.2%) were male and 101 (67.8%) were female. The observed difference in migraine prevalence among male and female was statistically significant (\n P<\/jats:italic>\n = 0.003). 198 (58.06%) patients were\n H. pylori<\/jats:italic>\n contaminated, among these 138 (69.7%) suffered from migraine. Among 143\n H. pylori<\/jats:italic>\n -negative patients, there were 11 (7.7%) migraineurs. The difference in the prevalence of migraine among\n H. pylori<\/jats:italic>\n positive and negative patients was significant.\n H. pylori<\/jats:italic>\n and GERD were associated with migraine with\n P<\/jats:italic>\n < 0.001. Patients with DU were more commonly suffering from migraine (\n P<\/jats:italic>\n = 0.001). The association in patients with GU was not statistically significant (\n P<\/jats:italic>\n = 0.863).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Migraine might be associated with GERD,\n H. pylori<\/jats:italic>\n infection, and DU, and the treatment of the underlying GI disorder may control headaches.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrms.jrms_464_18","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T04:23:01Z","timestamp":1564028581000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Migraine and gastric disorders: Are they associated?"],"prefix":"10.4103","volume":"24","author":[{"given":"Ahmad","family":"Hormati","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center, Qom University of Medical Sciences, Qom, Iran"},{"name":"Gastrointestinal and Liver Disease Research Center, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayyereh","family":"Akbari","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Sharifipour","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Amir","family":"Hejazi","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Shahid Beheshti Hospital, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Jafari","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Alemi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abolfaz","family":"Mohammadbeigi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Disease Research Center, Qom University of Medical Sciences, Qom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"R1-20250828","doi-asserted-by":"crossref","first-page":"e40061","DOI":"10.5812\/ircmj.40061","article-title":"The prevalence of migraine in Iran: A systematic review and meta-analysis","volume":"18","author":"Farhadi","year":"2016","journal-title":"Iran Red Crescent Med 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