{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:05:50Z","timestamp":1793019950880,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Background:<\/jats:title>\n Type 2 diabetes mellitus (T2DM) is prone to opportunistic infections, including toxoplasmosis, due to an immunodeficiency system. This study aimed to evaluate the serum of people with T2DM to determine the titer of anti-toxoplasma antibodies in patients and compare it with the control group.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n 720 blood samples have been carried out between October and the end of January 2017 in Sistan, and Baluchestan provinces in southeastern Iran, of these, 360 samples were related to healthy individuals (control), and 360 samples were related to T2DM individuals. The immunoglobulin (Ig) M and IgG enzyme-linked immunosorbent assay methods have been used to detect toxoplasmosis. The data were analyzed using SPSS-19, Chi-square, and Fisher\u2019s exact test to compare statistical parameters.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In this cross-sectional study, out of 360 samples of T2DM by ELISA method, 60% samples in diabetic patients and 48.1% in control group were IgG positive (\n P<\/jats:italic>\n < 0.05). Nearly 2.5% samples in diabetic patients and 0.3% in control group were IgM positive (\n P<\/jats:italic>\n < 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Anti-toxoplasma antibodies including IgG and IgM were higher in diabetic patient in comparison to control group.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrms.jrms_49_23","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T14:39:07Z","timestamp":1711636747000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Seroepidemiology of Toxoplasma gondii in diabetic patients type 2 by enzyme-linked immunosorbent assay method in Zabol City, 2017\u20132018"],"prefix":"10.4103","volume":"29","author":[{"given":"Mansour","family":"Dabirzadeh","sequence":"first","affiliation":[{"name":"Department of Parasitology and Mycology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Sargazi","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Zabol University of Medical Sciences, Zabol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Bagheri","sequence":"additional","affiliation":[{"name":"Department of Biostatics, Faculty of Health, Zabol University of Medical Science, Zabol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"195","DOI":"10.21608\/puj.2022.147655.1174","article-title":"Investigating the potential link between seroprevalence of Toxoplasma IgG and both types of diabetes mellitus in Benha city, Egypt","volume":"15","author":"Elkholy","year":"2022","journal-title":"Parasitol United J"},{"key":"R2-20240830","doi-asserted-by":"crossref","first-page":"8881908","DOI":"10.1155\/2021\/8881908","article-title":"High prevalence of Toxoplasma gondii Infection in type I diabetic patients","volume":"2021","author":"Asgari","year":"2021","journal-title":"J Parasitol Res"},{"key":"R3-20240830","first-page":"1","article-title":"The association between Toxoplasma gondii and type 2 diabetes mellitus: a systematic review and meta-analysis of human case-control studies","volume":"44","author":"Nosaka","year":"2020","journal-title":"Bull Natl Res Cent"},{"key":"R4-20240830","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.diabres.2016.04.016","article-title":"IDF Diabetes Atlas estimates of 2014 global health expenditures on diabetes","volume":"117","author":"da Rocha Fernandes","year":"2016","journal-title":"Diabetes Res Clin Pract"},{"key":"R5-20240830","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4723739","article-title":"Toxoplasma gondii infection in diabetes mellitus patients in China: seroprevalence, risk factors, and case-control studies","volume":"2018","author":"Li","year":"2018","journal-title":"Biomed Res Int"},{"key":"R6-20240830","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nature reviews immunology"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"106","DOI":"10.15171\/npj.2017.13","article-title":"Prevalence of anti-Toxoplasma IgG and IgM in hemodialysis patients comparing to healthy individuals in Sistan area, Iran","volume":"6","author":"Dorri","year":"2017","journal-title":"J Nephropharmacol"},{"issue":"3","key":"R8-20240830","article-title":"Investigation of IgG and IgM antibodies against Toxoplasma gondii among diabetic patients","volume":"2","author":"Modrek","year":"2015","journal-title":"International Journal of Infection"},{"key":"R9-20240830","first-page":"85","article-title":"Study the possible association between toxoplasmosis and diabetes mellitus in Iraq","volume":"6","author":"Molan","year":"2017","journal-title":"World J Pharm Pharm Sci"},{"key":"R10-20240830","doi-asserted-by":"crossref","first-page":"195","DOI":"10.21608\/puj.2022.147655.1174","article-title":"Investigating the potential link between seroprevalence of Toxoplasma IgG and both types of diabetes mellitus in Benha city, Egypt","volume":"15","author":"Elkholy","year":"2022","journal-title":"Parasitologists United Journal"},{"key":"R11-20240830","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42269-019-0059-0","article-title":"Seroprevalence of Toxoplasma gondii among a group of Egyptian patients with type I diabetes mellitus","volume":"43","author":"Khattab","year":"2019","journal-title":"Bull Natl Res Cent"},{"key":"R12-20240830","first-page":"637","article-title":"The correlation between serum levels of anti-Toxoplasma gondii antibodies and the risk of diabetes","volume":"13","author":"Khalili","year":"2018","journal-title":"Iranian journal of parasitology"},{"key":"R13-20240830","first-page":"49","article-title":"Is Toxoplasmosis a risk factor in diabetic patients in Tehran?","volume":"5","author":"Shamsinia","year":"2019","journal-title":"Infect Epidemiol Microbiol"},{"key":"R14-20240830","doi-asserted-by":"crossref","first-page":"8881908","DOI":"10.1155\/2021\/8881908","article-title":"High Prevalence of Toxoplasma gondii<\/i> Infection in Type I Diabetic Patients","volume":"2021","author":"Asgari","year":"2021","journal-title":"J Parasitol Res"},{"key":"R15-20240830","doi-asserted-by":"crossref","first-page":"701","DOI":"10.5812\/ircmj.5303","article-title":"Serologic detection of anti Toxoplasma gondii infection in diabetic patients","volume":"15","author":"Shirbazou","year":"2013","journal-title":"Iran Red Crescent Med J"},{"key":"R16-20240830","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.exppara.2018.04.007","article-title":"Toxoplasma gondii as a possible causative pathogen of type-1 diabetes mellitus: evidence from case--control and experimental studies","volume":"188","author":"Beshay","year":"2018","journal-title":"exp Parasitol"},{"key":"R17-20240830","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.bjid.2016.09.002","article-title":"Is chronic toxoplasmosis a risk factor for diabetes mellitus? A systematic review and meta-analysis of case-control studies","volume":"20","author":"Majidiani","year":"2016","journal-title":"Braz J Infect Dis"},{"key":"R18-20240830","doi-asserted-by":"crossref","first-page":"44","DOI":"10.15212\/FMCH.2016.0128","article-title":"The role of Toxoplasma gondii as a possible inflammatory agent in the pathogenesis of type 2 diabetes mellitus in humans","volume":"4","author":"Nosaka","year":"2016","journal-title":"Fam Med Community Health"}],"container-title":["Journal of Research in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jrms.jrms_49_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:28:01Z","timestamp":1787768881000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jrms.jrms_49_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jrms.jrms_49_23","relation":{},"ISSN":["1735-1995","1735-7136"],"issn-type":[{"value":"1735-1995","type":"print"},{"value":"1735-7136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-01-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}