{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:42:43Z","timestamp":1786725763110,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Whether combination administration of angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), and beta-blockers (BBs) has a \u201creversal\u201d effect on cardiac structure and function for first-diagnosed idiopathic dilated cardiomyopathy (FSIDCM) patients with unclear etiologies and inducements is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We studied the effect of the protocol on FSIDCM patients. The effect was investigated in 26 FSIDCM patients. The criteria of \u201ccomplete reversal\u201d included left ventricular end-diastolic diameter (LVEDD) \u226450 mm for females or \u226455 mm for males and left ventricular ejection fraction (LVEF) \u226545%; the criteria of \u201cpartial reversal\u201d was the decreased rate of LVEDD (\u0394LVEDD) &gt;10% or the increase rate of LVEF (\u0394LVEF) &gt;10%; the criteria of \u201cno reversal\u201d included LVEDD &gt;50 mm for females or &gt;55 mm for males and \u0394LVEDD &lt;10%, and LVEF &lt;45% and \u0394LVEF &lt;10%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Within the follow-up period, nine patients showed \u201ccomplete reversal,\u201d eight \u201cpartial reversal,\u201d and nine \u201cno reversal.\u201d Improvements in echocardiogram parameters were the most significant in \u201ccomplete reversal\u201d patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), followed by \u201cpartial reversal\u201d and \u201cno reversal\u201d patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The QRS (Q wave, R wave, S wave) duration and symptoms duration in \u201ccomplete reversal\u201d patients were the shortest, followed by \u201cpartial reversal\u201d and \u201cno reversal\u201d patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ACEIs or ARBs and BBs have a \u201ccomplete reversal\u201d effect on the left ventricular size and function of some FSIDCM patients. Patients with a narrow QRS and short symptom duration may have a good response.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jrms.jrms_626_21","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:45:21Z","timestamp":1692751521000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The complete reversal effect following angiotensin-converting enzyme inhibitors or angiotensin receptor blockers and beta-blockers after the primary diagnosis of dilated cardiomyopathy"],"prefix":"10.4103","volume":"28","author":[{"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Chongqing Institute of Cardiology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The First People\u2019s Hospital of Chongqing Liang Jiang New Area, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The People\u2019s Hospital of Chongqing Da Du Kou Area, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chongqing Institute of Cardiology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Shou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chongqing Institute of Cardiology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Chongqing Institute of Cardiology, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"R1-20240830","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/S0140-6736(16)31713-5","article-title":"Dilated cardiomyopathy","volume":"390","author":"Weintraub","year":"2017","journal-title":"Lancet"},{"key":"R2-20240830","first-page":"1","article-title":"Myocardial remodelling and recovery in dilated cardiomyopathy","volume":"6","author":"Tayal","year":"2017","journal-title":"JRSM Cardiovasc Dis"},{"key":"R3-20240830","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ejhf.16","article-title":"Long-term prognostic impact of therapeutic strategies in patients with idiopathic dilated cardiomyopathy: Changing mortality over the last 30 years","volume":"16","author":"Merlo","year":"2014","journal-title":"Eur J Heart Fail"},{"key":"R4-20240830","first-page":"421","article-title":"Chinese guidelines for the diagnosis and treatment of dilated cardiomyopathy","volume":"34","year":"2018","journal-title":"J Clin Cardiol (China)"},{"key":"R5-20240830","first-page":"315","article-title":"Prevalence and predictors of left ventricular reverse remodeling in patients with recent onset dilated cardiomyopathy on tailored medical therapy","volume":"44","author":"Zhang","year":"2016","journal-title":"Zhonghua Xin Xue Guan Bing Za Zhi"},{"key":"R6-20240830","first-page":"405","article-title":"Prevalence and clinical predictors of reverse remodeling in patients with dilated cardiomyopathy","volume":"16","author":"Arad","year":"2014","journal-title":"Isr Med Assoc J"},{"key":"R7-20240830","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1253\/circj.CJ-12-0507","article-title":"Predictors of left ventricular reverse remodeling and subsequent outcome in nonischemic dilated cardiomyopathy","volume":"77","author":"Choi","year":"2013","journal-title":"Circ J"},{"key":"R8-20240830","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0002-9149(99)00414-2","article-title":"Prevalence, predictors, and prognosis of reversal of maladaptive remodeling with intensive medical therapy in idiopathic dilated cardiomyopathy","volume":"84","author":"Kawai","year":"1999","journal-title":"Am J Cardiol"},{"key":"R9-20240830","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.amjcard.2010.11.033","article-title":"Effect of left ventricular reverse remodeling on long-term prognosis after therapy with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and b blockers in patients with idiopathic dilated cardiomyopathy","volume":"107","author":"Hoshikawa","year":"2011","journal-title":"Am J Cardiol"},{"key":"R10-20240830","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.amjcard.2012.08.056","article-title":"Left ventricular reverse remodeling in long-term (>12 years) survivors with idiopathic dilated cardiomyopathy","volume":"111","author":"Matsumura","year":"2013","journal-title":"Am J Cardiol"},{"key":"R11-20240830","doi-asserted-by":"crossref","first-page":"e001504","DOI":"10.1161\/JAHA.114.001504","article-title":"Persistent recovery of normal left ventricular function and dimension in idiopathic dilated cardiomyopathy during long-term follow-up: Does real healing exist?","volume":"4","author":"Merlo","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"R12-20240830","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12947-015-0009-4","article-title":"Prediction of left ventricular reverse remodeling after therapy with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and b blockers in patients with idiopathic dilated cardiomyopathy","volume":"13","author":"Matsumura","year":"2015","journal-title":"Cardiovasc Ultrasound"},{"key":"R13-20240830","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.amjcard.2014.06.021","article-title":"Frequency of recovery and relapse in patients with nonischemic dilated cardiomyopathy on guideline-directed medical therapy","volume":"114","author":"Gupta","year":"2014","journal-title":"Am J Cardiol"},{"key":"R14-20240830","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1253\/circj.CJ-17-0442","article-title":"J-CHF Investigators. Anemia is associated with blunted response to b-blocker therapy using carvedilol \u2013Insights from Japanese chronic heart failure (J-CHF) study","volume":"82","author":"Nagatomo","year":"2018","journal-title":"Circ J"},{"key":"R15-20240830","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(18)32484-X","article-title":"Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): An open-label, pilot, randomised trial","volume":"393","author":"Halliday","year":"2019","journal-title":"Lancet"},{"key":"R16-20240830","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1016\/j.jacc.2012.06.062","article-title":"Myocardial recovery and the failing heart: Myth, magic, or molecular target?","volume":"60","author":"Mann","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"R17-20240830","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1755-5922.2010.00247.x","article-title":"Myocardial reverse remodeling","volume":"30","author":"Hellawell","year":"2012","journal-title":"Cardiovasc Ther"},{"key":"R18-20240830","first-page":"52","article-title":"Reverse remodeling in dilated cardiomyopathy: Insights and future perspectives","volume":"18","author":"Merlo","year":"2018","journal-title":"Int J Cardiol Heart Vasc"},{"key":"R19-20240830","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1016\/j.jacc.2010.01.022","article-title":"Long-term reverse remodeling with cardiac resynchronization therapy: Results of extended echocardiographic follow-up","volume":"55","author":"Verhaert","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"R20-20240830","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/europace\/eut339","article-title":"Long-term outcome of 'super-responder'patients to cardiac resynchronization therapy","volume":"16","author":"Zecchin","year":"2014","journal-title":"Europace"}],"container-title":["Journal of Research in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jrms.jrms_626_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:25:20Z","timestamp":1786724720000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jrms.jrms_626_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jrms.jrms_626_21","relation":{},"ISSN":["1735-1995","1735-7136"],"issn-type":[{"value":"1735-1995","type":"print"},{"value":"1735-7136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2021-07-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-19","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}