{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:28:03Z","timestamp":1787840883348,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patent ductus arteriosus (PDA) is a common disease in premature neonates, which could occur in up to 50% of the neonates weighting &lt;1000 g. PDA might induce hemodynamic and respiratory disorders and increase mortality and morbidity. This study aimed to compare the effectiveness of oral ibuprofen and a low dose of intravenous acetaminophen in the management of PDA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This randomized double-blind clinical trial was conducted on the preterm neonates with an equal gestational age of &lt;34 weeks and weight of &gt;1000 g with symptomatic PDA, who were admitted in Shahid Beheshti and Al-Zahra Hospitals Affiliated to Isfahan University of Medical Sciences, Iran. In total, 40 preterm neonates were examined, 20 of whom received 15 mg\/kg\/6 h of intravenous acetaminophen for 2 days and 20 infants received 10 mg\/kg of intravenous ibuprofen on the 1\n                      <jats:sup>st<\/jats:sup>\n                      day and 5 mg\/kg for the next 2 days, and the results include vital signs and echocardiography findings were compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In the acetaminophen and ibuprofen groups, 16 (80%) and 17 neonates (85%) responded (PDA closure rate) to the treatment, respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.68). Furthermore, acetaminophen and ibuprofen have a similar effect on vital signs. Both drugs did not change in blood pressure, but they reduced the respiratory rate and heart rate after treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Low-dose acetaminophen compared to ibuprofen has an equal effectiveness in the closure of PDA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jrms.jrms_631_17","type":"journal-article","created":{"date-parts":[[2019,2,25]],"date-time":"2019-02-25T04:42:42Z","timestamp":1551069762000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Low-dose intravenous acetaminophen versus oral ibuprofen for the closure of patent ductus arteriosus in premature neonates"],"prefix":"10.4103","volume":"24","author":[{"given":"Mehdi","family":"Ghaderian","sequence":"first","affiliation":[{"name":"Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Mohammad","family":"Armanian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Growth and Development Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Sabri","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Montaseri","sequence":"additional","affiliation":[{"name":"Pediatric Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,2,25]]},"reference":[{"key":"R1-20250828","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.semperi.2011.09.022","article-title":"Patent ductus arteriosus: Are current neonatal treatment options better or worse than no treatment at all?","volume":"36","author":"Clyman","year":"2012","journal-title":"Semin Perinatol"},{"key":"R2-20250828","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1111\/j.1651-2227.2008.00871.x","article-title":"The fate of ductus arteriosus in infants at 23-27 weeks of gestation: From spontaneous closure to ibuprofen resistance","volume":"97","author":"Dani","year":"2008","journal-title":"Acta Paediatr"},{"key":"R3-20250828","first-page":"CD003481","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm and\/or low birth weight infants","volume":"4","author":"Ohlsson","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"R4-20250828","first-page":"CD003481","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm and\/or low birth weight infants","volume":"4","author":"Ohlsson","year":"2010","journal-title":"Cochrane Database of Syst Rev"},{"key":"R5-20250828","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-0029-1243371","article-title":"Safety and effectiveness of indomethacin versus ibuprofen for treatment of patent ductus arteriosus","volume":"27","author":"Katakam","year":"2010","journal-title":"Am J Perinatol"},{"key":"R6-20250828","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1055\/s-0029-1243315","article-title":"Treatment of patent ductus arteriosus: Indomethacin or ibuprofen?","volume":"27","author":"Linder","year":"2010","journal-title":"Am J Perinatol"},{"key":"R7-20250828","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pedneo.2015.04.017","article-title":"Repeated courses of oral ibuprofen in premature infants with patent ductus arteriosus: Efficacy and safety","volume":"58","author":"Olgun","year":"2017","journal-title":"Pediatr Neonatol"},{"key":"R8-20250828","doi-asserted-by":"crossref","first-page":"e5807","DOI":"10.5812\/ijp.5807","article-title":"The effects of oral ibuprofen on medicinal closure of patent ductus arteriosus in full-term neonates in the second postnatal week","volume":"26","author":"Alipour","year":"2016","journal-title":"Iran J Pediatr"},{"key":"R9-20250828","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00246-009-9542-y","article-title":"Oral ibuprofen and ductus arteriosus closure in full-term neonates: A prospective case-control study","volume":"31","author":"Amoozgar","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"R10-20250828","first-page":"CD010061","article-title":"Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants","volume":"3","author":"Ohlsson","year":"2015","journal-title":"Cochrane Database of Syst Rev"},{"key":"R11-20250828","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1177\/1060028014557564","article-title":"Acetaminophen for patent ductus arteriosus","volume":"49","author":"Le","year":"2015","journal-title":"Ann Pharmacother"},{"key":"R12-20250828","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jpeds.2014.04.025","article-title":"Acetaminophen: A possible alternative to ibuprofen in patent ductus arteriosus closure","volume":"165","author":"DeMauro","year":"2014","journal-title":"J Pediatr"},{"key":"R13-20250828","doi-asserted-by":"crossref","first-page":"e3975","DOI":"10.5812\/ijp.3975","article-title":"Comparison of oral acetaminophen versus ibuprofen in premature infants with patent ductus arteriosus","volume":"26","author":"Bagheri","year":"2016","journal-title":"Iran J Pediatr"},{"key":"R14-20250828","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.earlhumdev.2010.06.012","article-title":"Echocardiography predicts closure of patent ductus arteriosus in response to ibuprofen in infants less than 28 week gestational age","volume":"86","author":"Pees","year":"2010","journal-title":"Early Hum Dev"},{"key":"R15-20250828","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13063-016-1294-4","article-title":"Efficacy and safety of intravenous paracetamol in comparison to ibuprofen for the treatment of patent ductus arteriosus in preterm infants: Study protocol for a randomized control trial","volume":"17","author":"Dani","year":"2016","journal-title":"Trials"},{"key":"R16-20250828","doi-asserted-by":"crossref","first-page":"e1618","DOI":"10.1542\/peds.2011-0359","article-title":"Ductal closure with paracetamol: A surprising new approach to patent ductus arteriosus treatment","volume":"128","author":"Hammerman","year":"2011","journal-title":"Pediatrics"},{"key":"R17-20250828","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000345337","article-title":"Intravenous paracetamol treatment in the management of patent ductus arteriosus in extremely low birth weight infants","volume":"103","author":"Oncel","year":"2013","journal-title":"Neonatology"},{"key":"R18-20250828","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.jpeds.2010.10.008","article-title":"Efficacy and safety of oral versus intravenous ibuprofen in very low birth weight preterm infants with patent ductus arteriosus","volume":"158","author":"Gokmen","year":"2011","journal-title":"J Pediatr"},{"key":"R19-20250828","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00431-016-2830-7","article-title":"Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus 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