{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:36:22Z","timestamp":1788305782193,"version":"build-2803163510"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>There is interest about the role of platelet (PLT) number and function in nonalcoholic fatty liver disease (NAFLD). NAFLD patients have abnormalities of PLT number and function, especially mean platelet volume (MPV) which is known as a novel biomarker for atherosclerosis. We decided to compare PLT number and function between NAFLD and healthy participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In this case\u2013control study, two groups of patients (65 cases with NAFLD and 65 cases without NAFLD) were included consecutively. The diagnosis of NAFLD was made using ultrasound examination of the liver. Venous blood samples were taken, and the required laboratory markers including PLT number and function (MPV, platelet distribution width [PDW]), prothrombin time (PT), partial thromboplastin time (PTT), lipid profile, hepatic transaminases, ferritin, and fasting blood sugar were assayed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean (\u00b1 standard deviation [SD]) MPV in NAFLD group (10.29 \u00b1 0.95 fL) was significantly higher than in control group (9.56 \u00b1 1.18 fL);\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001. No significant difference was observed regarding mean (\u00b1 SD) PLT count between NAFLD (271.20 \u00b1 52.11 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      \/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) and healthy participants (262.86 \u00b1 75.81 \u00d7 10\n                      <jats:sup>3<\/jats:sup>\n                      \/mm\n                      <jats:sup>3<\/jats:sup>\n                      ) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.46). Mean (\u00b1 SD) PDW values were not significantly different between NAFLD and control groups. Logistic regression showed that NAFLD was positively associated with higher MPV (odds ratio [OR] =1.9, 95% confidence interval [CI] =1.20\u20133.02) and body mass index (OR = 1.5, 95% CI = 1.05\u20132.15) values. However, PT (OR = 0.14, 95% CI = 0.02\u20130.82) and PTT (OR = 0.72, 95% CI = 0.58\u20130.88) had negative association with NAFLD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Higher MPV was found to be significantly associated with NAFLD. However, such significant association was not detected regarding PLT count or PDW. As MPV is a reported risk factor for atherosclerosis, this marker may be useful in follow-up of patients with NAFLD. These findings provide basis for further studies to address this marker in long-term follow-up of NAFLD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jrms.jrms_711_16","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T05:46:54Z","timestamp":1498024014000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of platelet number and function between nonalcoholic fatty liver disease and normal individuals"],"prefix":"10.4103","volume":"22","author":[{"given":"Zeinab","family":"Saremi","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Valiasr Hospital, Birjand, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobe","family":"Rastgoo","sequence":"additional","affiliation":[{"name":"General Practitioner, Imam Reza Hospital, Birjand, 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