{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:35Z","timestamp":1787840555643,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Background:<\/jats:title>\n This study aimed to determine the prevalence of glucose metabolism disorder and dyslipidemia in 14\u201318-year-old girls with different phenotype polycystic ovary syndrome (PCOS).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n This descriptive, cross-sectional study was conducted on 3200 high-school adolescents aged 14\u201318 years in Shiraz in 2010. Selected parameters of metabolic syndrome (fasting blood glucose, glucose tolerance test [GTT], insulin level, triglyceride (TG), cholesterol, and high-density lipoprotein [HDL]), based on adult treatment panel \u0428 definition criteria, were compared between the \u201cPCOS\u201d and control groups.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Results were compared at four main phenotypes. The level of serum TG was increased in the Phenotype B (\n P<\/jats:italic>\n = 0.03) and Phenotype D (\n P<\/jats:italic>\n = 0.01), compared to the control group. Cholesterol and low-density lipoprotein levels (\n P<\/jats:italic>\n < 0.05) and GTT (\n P<\/jats:italic>\n > 0.05) were increased, and HDL was decreased (was below 50) in all the four phenotypes and the control group (\n P<\/jats:italic>\n > 0.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The risk of metabolic alterations of glucose metabolism disorder and dyslipidemia in PCOS adolescents was more than non-PCOS counterparts.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrms.jrms_804_16","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T01:14:31Z","timestamp":1567041271000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["The glucose metabolism disorder and dyslipidemia among girls with different phenotype polycystic ovary syndrome"],"prefix":"10.4103","volume":"24","author":[{"given":"Marzieh","family":"Akbarzadeh","sequence":"first","affiliation":[{"name":"Department of Midwifery, Maternal\u2013Fetal Medicine Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahereh","family":"Naderi","sequence":"additional","affiliation":[{"name":"Community Based Psychiatric Care Research Centre, Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad H","family":"Dabbaghmanesh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Endocrine and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"R1-20250828","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"key":"R2-20250828","first-page":"1012","article-title":"Use of insulin sensitizers in polycystic ovarian syndrome","volume":"6","author":"Baillargeon","year":"2005","journal-title":"Curr Opin Investig Drugs"},{"key":"R4-20250828","first-page":"82","article-title":"The survey of central obesity and BMI associated with different phenotypes of polycystic ovary syndrome in adolescents","volume":"3","author":"Akbarzadeh","year":"2015","journal-title":"Int J Afr Nurs Sci"},{"key":"R5-20250828","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1161\/CIRCULATIONAHA.109.887521","article-title":"Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men","volume":"121","author":"Arnl\u00f6v","year":"2010","journal-title":"Circulation"},{"key":"R6-20250828","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1586\/erc.10.13","article-title":"Metabolic syndrome as a risk factor for diabetes","volume":"8","author":"Aschner","year":"2010","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"R7-20250828","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.jpeds.2009.04.043","article-title":"Understanding the nature of metabolic syndrome components in children and what they can and cannot do to predict adult disease","volume":"155","author":"Huang","year":"2009","journal-title":"J Pediatr"},{"key":"R8-20250828","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/archpediatrics.2009.3","article-title":"Prevalence of risk factors for metabolic syndrome in adolescents: National health and nutrition examination survey (NHANES), 2001-2006","volume":"163","author":"Johnson","year":"2009","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R9-20250828","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/met.2009.0024","article-title":"The metabolic syndrome in South Asians: Epidemiology, determinants, and prevention","volume":"7","author":"Misra","year":"2009","journal-title":"Metab Syndr Relat Disord"},{"key":"R10-20250828","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.2337\/dc09-0023","article-title":"Incidence and trend of a metabolic syndrome phenotype among Tehranian adolescents: Findings from the Tehran lipid and glucose study, 1998-2001 to 2003-2006","volume":"33","author":"Afkhami-Ardekani","year":"2010","journal-title":"Diabetes Care"},{"key":"R11-20250828","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3923\/ajd.2013.11.21","article-title":"The survey of cutaneous manifestations in adolescents suffering from poly cystic ovarian syndrome","volume":"5","author":"Akbarzadeh","year":"2013","journal-title":"Asian J Dermatol"},{"key":"R12-20250828","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/22201009.2013.10872312","article-title":"A survey of metabolic syndrome in first-degree relatives (fathers) of patients with polycystic ovarian syndrome","volume":"18","author":"Akbarzadeh","year":"2013","journal-title":"J Endocrinol Metab Diabetes South Afr"},{"key":"R13-20250828","doi-asserted-by":"crossref","first-page":"e1390","DOI":"10.1542\/peds.2006-1062","article-title":"Recent trends in waist circumference and waist-height ratio among US children and adolescents","volume":"118","author":"Li","year":"2006","journal-title":"Pediatrics"},{"issue":"Suppl 1","key":"R14-20250828","first-page":"S5","article-title":"Diagnosis and classification of diabetes mellitus","volume":"27","year":"2004","journal-title":"Diabetes Care"},{"key":"R15-20250828","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","year":"2004","journal-title":"Fertil Steril"},{"key":"R16-20250828","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00431-010-1143-5","article-title":"Prevalence of metabolic syndrome in a Portuguese obese adolescent population according to three different definitions","volume":"169","author":"Braga-Tavares","year":"2010","journal-title":"Eur J Pediatr"},{"key":"R17-20250828","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1477-7827-12-89","article-title":"The prevalence of metabolic disorders in various phenotypes of polycystic ovary syndrome: A community based study in Southwest of Iran","volume":"12","author":"Tehrani","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"R18-20250828","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1056\/NEJM199806043382302","article-title":"Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study","volume":"338","author":"Berenson","year":"1998","journal-title":"N Engl J Med"},{"key":"R19-20250828","doi-asserted-by":"crossref","first-page":"33","DOI":"10.4103\/jrms.JRMS_90_17","article-title":"Effect of chamomile capsule on lipid- and hormonal-related parameters among women of reproductive age with polycystic ovary syndrome","volume":"23","author":"Heidary","year":"2018","journal-title":"J Res Med Sci"},{"key":"R20-20250828","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1542\/peds.2006-1699","article-title":"Metabolic syndrome in childhood predicts adult cardiovascular disease 25 years later: The Princeton lipid research clinics follow-up study","volume":"120","author":"Morrison","year":"2007","journal-title":"Pediatrics"},{"key":"R21-20250828","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.2337\/diacare.20.7.1183","article-title":"Report of the expert committee on the diagnosis and classification of diabetes mellitus","volume":"20","year":"1997","journal-title":"Diabetes Care"},{"key":"R22-20250828","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/humrep\/det255","article-title":"Assessment of glucose metabolism in polycystic ovary syndrome: HbA1c or fasting glucose compared with the oral glucose tolerance test as a screening method","volume":"28","author":"Lerchbaum","year":"2013","journal-title":"Hum Reprod"},{"key":"R23-20250828","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5152\/jtgga.2014.95776","article-title":"What do we know about metabolic syndrome in adolescents with PCOS?","volume":"15","author":"C\u0131r\u0131k","year":"2014","journal-title":"J Turk Ger Gynecol Assoc"},{"key":"R24-20250828","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1161\/CIRCULATIONAHA.106.669994","article-title":"Instability in the diagnosis of metabolic syndrome in adolescents","volume":"115","author":"Goodman","year":"2007","journal-title":"Circulation"},{"key":"R25-20250828","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1093\/humrep\/des018","article-title":"Comparison of the phenotype of Chinese versus Dutch Caucasian women presenting with polycystic ovary syndrome and oligo\/amenorrhoea","volume":"27","author":"Guo","year":"2012","journal-title":"Hum Reprod"},{"key":"R26-20250828","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1093\/humrep\/der418","article-title":"Insulin resistance and endocrine characteristics of the different phenotypes of polycystic ovary syndrome: A prospective study","volume":"27","author":"Panidis","year":"2012","journal-title":"Hum Reprod"}],"container-title":["Journal of Research in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01222967-201924000-00072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:24:58Z","timestamp":1787837098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01222967-201924000-00072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/jrms.jrms_804_16","relation":{},"ISSN":["1735-1995","1735-7136"],"issn-type":[{"value":"1735-1995","type":"print"},{"value":"1735-7136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2016-11-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-01","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}