{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:02:57Z","timestamp":1789718577464,"version":"4.0.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Chemotherapy-induced nausea and vomiting (CINV) is considered as the most common complications of chemotherapy which has a detrimental influence on the quality of life of patients with cancer. We assessed the efficacy of Apple (\n                      <jats:italic toggle=\"yes\">Malus domestica<\/jats:italic>\n                      ) syrup for reducing CINV.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This study was a randomized, double-blind, placebo-controlled trial carried out in a Hematooncology Clinic affiliated to Mazandaran University of Medical Sciences, Sari, Iran (from October 2017 to August 2018). Subjects were randomly allocated to receive apple syrup or placebo along with their previous antiemetic treatment and chemotherapy regimen, three times a day. Thirty-four patients received apple syrup (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 16) or placebo (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 18). Statistical analysis was conducted using SPSS software Version 21\n                      <jats:sup>\u00ae<\/jats:sup>\n                      (SPSS Inc., Chicago, IL, USA). A\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 indicated statistical significance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Both acute and delayed nausea grades were significantly lower in\n                      <jats:italic toggle=\"yes\">M. domestica<\/jats:italic>\n                      syrup in comparison to placebo syrup (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001 and 0.001, respectively). The duration of nausea (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.04) was lower in intervention group compared to placebo group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      These findings demonstrated that\n                      <jats:italic toggle=\"yes\">M. domestica<\/jats:italic>\n                      syrup can reduce the severity and duration of nausea in cancer patients who received chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jrms.jrms_833_20","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T01:41:22Z","timestamp":1690854082000},"page":"72","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Malus domestica reduces chemotherapy-induced nausea and vomiting"],"prefix":"10.4103","volume":"26","author":[{"given":"Sharareh","family":"Darvishpour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razieh","family":"Avan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Azadbakht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monireh","family":"Maham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem","family":"Janbabaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Zaboli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Reza","family":"Amirabadizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebrahim","family":"Salehifar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-72-20240830","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00520-008-0422-4","article-title":"Frequency of side effects in outpatient cancer care and their influence on patient satisfaction \u2013 A prospective survey using the PASQOC\u00ae questionnaire","volume":"16","author":"Feyer","year":"2008","journal-title":"Support Care Cancer"},{"key":"R2-72-20240830","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000431256","article-title":"Role of psychosocial variables on chemotherapy-induced nausea and vomiting and health-related quality of life among cancer patients: A European study","volume":"84","author":"Grassi","year":"2015","journal-title":"Psychother Psychosom"},{"key":"R3-72-20240830","doi-asserted-by":"crossref","first-page":"v119","DOI":"10.1093\/annonc\/mdw270","article-title":"2016 MASCC and ESMO guideline update for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting and of nausea and vomiting in advanced cancer patients","volume":"27","author":"Roila","year":"2016","journal-title":"Ann Oncol"},{"key":"R4-72-20240830","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00520-018-4464-y","article-title":"ASCO, NCCN, MASCC\/ESMO: A comparison of antiemetic guidelines for the treatment of chemotherapy-induced nausea and vomiting in adult patients","volume":"27","author":"Razvi","year":"2019","journal-title":"Support Care Cancer"},{"key":"R5-72-20240830","doi-asserted-by":"crossref","first-page":"883","DOI":"10.6004\/jnccn.2017.0117","article-title":"NCCN guidelines insights: Antiemesis, version 2. 2017","volume":"15","author":"Berger","year":"2017","journal-title":"J Natl Compr Canc Netw"},{"key":"R6-72-20240830","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00520-016-3313-0","article-title":"2016 Updated MASCC\/ESMO consensus recommendations: Prevention of nausea and vomiting following high emetic risk chemotherapy","volume":"25","author":"Herrstedt","year":"2017","journal-title":"Support Care Cancer"},{"key":"R7-72-20240830","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1200\/JOP.2017.026351","article-title":"Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update Summary","volume":"13","author":"Hesketh","year":"2017","journal-title":"J Oncol Pract"},{"key":"R8-72-20240830","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ctcp.2019.01.004","article-title":"Complementary and alternative medicine use in cancer: A systematic review","volume":"35","author":"Keene","year":"2019","journal-title":"Complement Ther Clin Pract"},{"key":"R9-72-20240830","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1177\/1534735411413266","article-title":"Medicinal plants as antiemetics in the treatment of cancer: A review","volume":"11","author":"Haniadka","year":"2012","journal-title":"Integr Cancer Ther"},{"key":"R16-72-20240830","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.oraloncology.2012.01.004","article-title":"Comparison of the NCI-CTCAE version 4.0 and version 3.0 in assessing chemoradiation-induced oral mucositis for locally advanced nasopharyngeal carcinoma","volume":"48","author":"Liu","year":"2012","journal-title":"Oral Oncol"},{"key":"R17-72-20240830","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/BF00441561","article-title":"Apple juice, fructose, and chronic nonspecific diarrhoea","volume":"148","author":"Kneepkens","year":"1989","journal-title":"Eur J Pediatr"},{"key":"R18-72-20240830","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1039\/C6FO01378C","article-title":"Apple and pear consumption and type 2 diabetes mellitus risk: A meta-analysis of prospective cohort studies","volume":"8","author":"Guo","year":"2017","journal-title":"Food Funct"},{"key":"R19-72-20240830","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0002-8223(21)00562-9","article-title":"Improved food intake and reduced nausea and vomiting in patients given a restricted diet while receiving cisplatin chemotherapy","volume":"92","author":"Menashian","year":"1992","journal-title":"J Am Diet Assoc"},{"key":"R20-72-20240830","first-page":"448","article-title":"Total antioxidant capacity in aqueous extracts of some common fruits","volume":"2","author":"Jamuna","year":"2011","journal-title":"Int J Pharm Sci Res"},{"key":"R21-72-20240830","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/10408398.2013.865590","article-title":"Ginger \u2013 Mechanism of action in chemotherapy-induced nausea and vomiting: A review","volume":"57","author":"Marx","year":"2017","journal-title":"Crit Rev Food Sci Nutr"}],"container-title":["Journal of Research in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jrms.JRMS_833_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:10Z","timestamp":1787761030000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jrms.JRMS_833_20"}},"subtitle":["A randomized double-blind placebo-controlled clinical trial"],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jrms.jrms_833_20","relation":{},"ISSN":["1735-1995"],"issn-type":[{"value":"1735-1995","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}