{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:29:10Z","timestamp":1787758150694,"version":"build-2784847793"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"\n Background:<\/jats:title>\n Breast cancer is among the most common malignancies in women around the world. There is evidence of high prevalence of serum\/blood Vitamin D deficiency in Iranian women. Considering the multitude of factors that may be involved in the prognosis and lifespan of breast cancer patients, this study investigated the level of Vitamin D in Iranian patients with nonmetastatic breast cancer.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n \n This cross-sectional study was carried out on 214 women diagnosed with breast cancer, who were referred to the radio-oncology department. Serum Vitamin D level of the patients was measured. Prognostic factors were determined based on demographic and pathological characteristics. The results were analyzed using descriptive statistics tests, Chi-square, one-way analysis of variance, Kaplan\u2013Meier, and Cox regression model in SPSS v22. For all cases, the significance level was considered to be\n P<\/jats:italic>\n < 0.05.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n The total mean of 25-hydroxyvitamin D serum level was 25.15 \u00b1 17.68 ng\/ml. There was no significant relationship between levels of Vitamin D with disease stage, tumor size, tumor grade, estrogen receptor, progesterone receptor, and Human epidermal growth factor receptor 2 (\n P<\/jats:italic>\n > 0.05). The mean survival time was 5 years and 45 days.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n No relationship was found between serum Vitamin D levels and the factors affecting the prognosis of nonmetastatic breast cancer. The Cox analysis showed that the survival time was not influenced by Vitamin D as a prognosis factor.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrms.jrms_951_21","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T07:22:58Z","timestamp":1659079378000},"page":"56","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Association between serum Vitamin D levels and prognostic factors in nonmetastatic breast cancer patients"],"prefix":"10.4103","volume":"27","author":[{"given":"Mohammad 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