{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:17:31Z","timestamp":1787764651432,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Histoplasmosis due to\n Histoplasma duboisii<\/jats:italic>\n is an emerging AIDS-defining opportunistic infection in HIV positive seen predominantly on the African continent between the Tropics of Cancer and Capricorn.\n Histoplasma duboisii<\/jats:italic>\n is an invasive fungal organism with tropism for lymph nodes, skin and bones. The infection occurs more in patients with a CD4 count <50\/mm\n 3<\/jats:sup>\n and is usually dissemnnated Histoplasmosis due to\n Histoplasma duboisii<\/jats:italic>\n is an emerging AIDS-defining opportunistic infection in HIV positive seen predominantly on the African continent between the Tropics of Cancer and Capricorn.\n Histoplasma duboisii<\/jats:italic>\n is an invasive fungal organism with tropism for lymph nodes, skin and bones. The infection occurs more in patients with a CD4 count <50\/mm\n 3<\/jats:sup>\n and is usually disseminated. Literature reports of its occurrence in HIV negative patients are scanty. We report a case of histoplasma dubiosii infection of the left femur in a 9 year old HIV negative Nigerian with swelling in the left thigh of 5 months duration. Oral antibiotics and analgesics were prescribed for the patient with satisfactory clinical outcome. To our knowledge, this is the first reported case in an immunocompetent child in Nigeria. Literature reports of its occurrence in HIV negative patients are scanty. We report a case of histoplasma dubiosii infection of the left femur in a 9 year old HIV negative Nigerian with swelling in the left thigh of 5 months duration. Oral antibiotics and analgesics were prescribed for the patient with satisfactory clinical outcome. To our knowledge, this is the first reported case in an immunocompetent child in Nigeria.\n <\/jats:p>","DOI":"10.4103\/jrms.jrms_97_18","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T02:16:56Z","timestamp":1690856216000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Histoplasma duboisii of the femoral bone"],"prefix":"10.4103","volume":"24","author":[{"given":"Amechi Uchenna","family":"Katchy","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, University of Nigeria Teaching Hospital, Nsukka, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Uwale","family":"Eyesan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bowen University Teaching Hospital, Ogbomosho, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy Olufemi","family":"Awotunde","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bowen University Teaching Hospital, Ogbomosho, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Adesope","family":"Adesina","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bowen University Teaching Hospital, Ogbomosho, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babajide Oladayo","family":"Ayandele","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Bowen University Teaching Hospital, Ogbomosho, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatus","family":"Sabageh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Lautech Teaching Hospital, Ogbomosho, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"R1-20250828","doi-asserted-by":"crossref","first-page":"e0006046","DOI":"10.1371\/journal.pntd.0006046","article-title":"Histoplasmosis in Africa: An emerging or a neglected disease?","volume":"12","author":"Oladele","year":"2018","journal-title":"PLoS Negl Trop Dis"},{"key":"R2-20250828","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.3201\/eid1311.070665","article-title":"Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients","volume":"13","author":"Loulergue","year":"2007","journal-title":"Emerg Infect Dis"},{"key":"R3-20250828","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/ijd.12683","article-title":"African histoplasmosis: The first report of an indigenous case in India","volume":"54","author":"Ravindran","year":"2015","journal-title":"Int J 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varieties and geographical groups of the human pathogenic fungus Histoplasma capsulatum darling","volume":"37","author":"Kasuga","year":"1999","journal-title":"J Clin Microbiol"},{"key":"R8-20250828","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s10096-008-0668-2","article-title":"Disseminated histoplasmosis by Histoplasma capsulatum var. duboisii in a paediatric patient from the chad republic, Africa","volume":"28","author":"Garcia-Gui\u00f1on","year":"2009","journal-title":"Eur J Clin Microbiol Infect Dis"}],"container-title":["Journal of Research in Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01222967-201924000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:17:29Z","timestamp":1787761049000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01222967-201924000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.4103\/jrms.jrms_97_18","relation":{},"ISSN":["1735-1995","1735-7136"],"issn-type":[{"value":"1735-1995","type":"print"},{"value":"1735-7136","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"2018-02-10","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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