{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T01:12:34Z","timestamp":1789521154426,"version":"build-2803163510"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4]]},"abstract":"\n Objective:<\/jats:title>\n This study was conducted to evaluate the combination of oral supplements with 2% minoxidil solution in four groups of women with hair loss.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A prospective, randomized controlled trial was conducted from July to December 2016 in dermatology clinics affiliated to Isfahan University of Medical Sciences. A total of 73, 15\u201345-year-old, women with hair loss participated in this 4-month study. Simple randomization using Random Allocation Software was done to put the participants in four groups to receive coadministration of zinc sulfate and calcium pantothenate, zinc sulfate, calcium pantothenate, and 2% minoxidil solution. The primary endpoint was the change in hair density and diameter measured by dermatoscope. Secondary endpoints included the researcher's evaluation, dermatologist's opinion - which was blinded to the study - from comparing the participants\u2019 photographs before and after treatment and finally, overall changes in hair density measured by participants\u2019 self-assessment.<\/jats:p>\n <\/jats:sec>\n \n Findings:<\/jats:title>\n \n Seventy-three women participated in this study. Primary hair count and thickness were 118.5 \u00b1 10 hairs\/cm\n 2<\/jats:sup>\n and 58.8 \u00b1 5.8 \u03bc that changed to 124 \u00b1 11 hairs\/cm\n 2<\/jats:sup>\n and 62.3 \u00b1 4.3 \u03bc respectively (\n P<\/jats:italic>\n < 0.001) which in the zinc plus pantothenate group these changes were from 118.6 \u00b1 9.9 hairs\/cm\n 2<\/jats:sup>\n to 121.9 \u00b1 11.1 hairs\/cm\n 2<\/jats:sup>\n (\n P<\/jats:italic>\n = 0.042) and from 62.2 \u00b1 6.6 \u03bc to 64.0 \u00b1 5.0 \u03bc (\n P<\/jats:italic>\n = 0.126), respectively. Hair density increments were more obvious in the minoxidil group, and hair thickness increments were more obvious in pantothenate group. Participants\u2019 satisfaction was 85% in the combination therapy which was more than other groups. Participants\u2019 satisfaction, author's and blind dermatologist's opinion showed a significant correlation (\n P<\/jats:italic>\n = 0.0001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Based on the participants\u2019 satisfaction, the combination of zinc sulfate and calcium pantothenate when administered in a pulse therapy way could be a good choice for hair loss controlling in initial stages.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrpp.jrpp_17_17","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:25:05Z","timestamp":1496276705000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Comparing the Effects of Zinc Sulfate, Calcium Pantothenate, Their Combination and Minoxidil Solution Regimens on Controlling Hair Loss in Women: A Randomized Controlled Trial"],"prefix":"10.4103","volume":"6","author":[{"given":"Mansour","family":"Siavash","sequence":"first","affiliation":[{"name":"Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fereshteh","family":"Tavakoli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Science, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250525","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/jocd.12127","article-title":"Effect of a nutritional supplement on hair loss in 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