{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:31:05Z","timestamp":1787776265952,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:p>Serotonin toxicity is a common but often unrecognized toxicological condition. In most cases, a combination of two or more serotonergic drugs can cause serotonin syndrome. We describe a case of serotonin toxicity in a 17-year-old woman, secondary to suicidal ingestion of 1000 mg lamotrigine and 400 mg citalopram, which has been rarely reported. Our patient had a medical history of depression and was treated with lamotrigine and citalopram. She was brought to the emergency room with nausea, diaphoresis, agitation, shivering, tremor, vertigo, ataxia, mydriasis, nystagmus, hyperreflexia, myoclonus, tachycardia, tachypnea, and mild fever. The symptoms and signs were resolved within 3 days following hydration, sedation, and cyproheptadine. Minor cardiovascular symptoms are probably due to the less toxic dose of citalopram. Lamotrigine, especially in combination with other serotonergic drugs, should be considered a cause of serotonin toxicity.<\/jats:p>","DOI":"10.4103\/jrpp.jrpp_19_105","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T09:49:13Z","timestamp":1602150553000},"page":"158-160","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Serotonin Toxicity Following Suicide with Citalopram and Lamotrigine: A Rare Case Report and Literature Review"],"prefix":"10.4103","volume":"9","author":[{"given":"Gholamali","family":"Dorooshi","sequence":"first","affiliation":[{"name":"Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafeajafar","family":"Zoofaghari","sequence":"additional","affiliation":[{"name":"Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokhsareh","family":"Meamar","sequence":"additional","affiliation":[{"name":"Department of Clinical Toxicology, Isfahan Clinical Toxicology Research Center, Khorshid Hospital, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"R3-20250523","first-page":"1199","article-title":"Cervical spinal cord stimulation with concomitant serotonin norepinephrine reuptake inhibitor therapy leading to the serotonin syndrome","volume":"18","author":"Dizdarevic","year":"2017","journal-title":"Pain Med"},{"key":"R4-20250523","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1177\/2045125316656707","article-title":"Safety profile of lamotrigine in overdose","volume":"6","author":"Alabi","year":"2016","journal-title":"Ther Adv Psychopharmacol"},{"key":"R5-20250523","doi-asserted-by":"crossref","first-page":"769531","DOI":"10.1155\/2015\/769531","article-title":"Serotonin syndrome in the setting of lamotrigine, aripiprazole, and cocaine use","volume":"2015","author":"Kotwal","year":"2015","journal-title":"Case Rep Med"},{"key":"R6-20250523","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1024\/1422-4917\/a000613","article-title":"Non-fatal intoxication with a high dose of citalopram in a suicidal 14-year-old girl","volume":"47","author":"Weigl","year":"2019","journal-title":"Z Kinder Jugendpsychiatr Psychother"},{"key":"R7-20250523","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/tpj.2013.47","article-title":"Serotonin toxicity from antidepressant overdose and its association with the T102C polymorphism of the 5-HT2A receptor","volume":"14","author":"Cooper","year":"2014","journal-title":"Pharmacogenomics J"},{"key":"R8-20250523","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1001\/jamaneurol.2013.95","article-title":"Serotonin syndrome associated with clozapine withdrawal","volume":"70","author":"Stevenson","year":"2013","journal-title":"JAMA Neurol"},{"key":"R9-20250523","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3109\/15563650.2015.1009993","article-title":"Serotonin syndrome following metaxalone overdose and therapeutic use of a selective serotonin reuptake inhibitor","volume":"53","author":"Martini","year":"2015","journal-title":"Clin Toxicol (Phila)"},{"key":"R10-20250523","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/jcpt.12698","article-title":"Bicarbonate refractory QRS prolongation and left bundle-branch block following escitalopram and lamotrigine overdose: A case report and literature review of toxic left bundle-branch block","volume":"43","author":"Farkas","year":"2018","journal-title":"J Clin Pharm Ther"}],"container-title":["Journal of Research in Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jrpp.JRPP_19_105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:04:43Z","timestamp":1787774683000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jrpp.JRPP_19_105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/jrpp.jrpp_19_105","relation":{},"ISSN":["2319-9644","2279-042X"],"issn-type":[{"value":"2319-9644","type":"print"},{"value":"2279-042X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2019-10-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}