{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:22:51Z","timestamp":1787844171875,"version":"build-2784847793"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,1]]},"abstract":"\n Objective:<\/jats:title>\n Opioid abuse is widespread throughout the world. Aspiration pneumonia is a serious problem following opioid overdose and poisoning. This study aimed to evaluate the safety and effectiveness of antimicrobial management of opioid-overdose induced aspiration pneumonia in a referral poisoning management university hospital in Iran.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In an observational cross-sectional study (September\u2013March 2019), opioid poisoned patients diagnosed with aspiration pneumonia within a maximum of 48 h of their overdose were evaluated regarding several variables, including the level of consciousness on admission, drug regimen used for the treatment of aspiration pneumonia, and its appropriateness, and the correctness of the used antibiotics dose and the therapeutic outcome.<\/jats:p>\n <\/jats:sec>\n \n Findings:<\/jats:title>\n \n During the study, 53 eligible patients were identified and included in the study. The most frequently abused opioids were methadone (60.4%) and opium (17%). \u201cCeftriaxone + Clindamycin\u201d (54.7%) and \u201cMeropenem + Vancomycin\u201d (9.5%) were the most frequently administered regimens. Regarding treatment outcome, most cases (\n n<\/jats:italic>\n = 36, 67.9%) were discharged with a stable and satisfying medical status, while 3.8% of the cases (\n n<\/jats:italic>\n = 2) died.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The use of antibiotics in the treatment of aspiration pneumonia in hospitalized patients with opioid overdose in our referral university hospital is associated with notable antibiotic regimen choice issues. The implementation of strategies for improving the pattern of antibiotic prescribing for these patients is necessary.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jrpp.jrpp_21_17","type":"journal-article","created":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T13:22:55Z","timestamp":1620220975000},"page":"38-42","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["The Safety and Effectiveness of Pharmacotherapy for Opioid-Overdose Induced Aspiration Pneumonia in a Referral Poisoning Management University Hospital in Iran"],"prefix":"10.4103","volume":"10","author":[{"given":"Mohammadreza","family":"Tabatabaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gholamali","family":"Dorvashy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasoul","family":"Soltani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiva","family":"Samsamshariat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokhsareh","family":"Meamar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Mohammad","family":"Sabzghabaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20240907","first-page":"327","article-title":"A narrative review of acute adult poisoning in Iran","volume":"42","author":"Alinejad","year":"2017","journal-title":"Iran J Med Sci"},{"key":"R2-6-20240907","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1378\/chest.111.5.1266","article-title":"Quantitative aspiration during sleep in normal subjects","volume":"111","author":"Gleeson","year":"1997","journal-title":"Chest"},{"key":"R3-6-20240907","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.amjmed.2013.07.012","article-title":"Risk factors for aspiration in community-acquired pneumonia: Analysis of a hospitalized UK cohort","volume":"126","author":"Taylor","year":"2013","journal-title":"Am J Med"},{"key":"R4-6-20240907","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1056\/NEJMra1714562","article-title":"Aspiration pneumonia","volume":"380","author":"Mandell","year":"2019","journal-title":"N Engl J Med"},{"key":"R6-6-20240907","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.bjp.0701138","article-title":"Antinociceptive and immunosuppressive effects of opiate drugs: A structure-related activity study","volume":"121","author":"Sacerdote","year":"1997","journal-title":"Br J Pharmacol"},{"key":"R7-6-20240907","doi-asserted-by":"crossref","first-page":"S737","DOI":"10.1093\/clinids\/13.Supplement_9.S737","article-title":"Aspiration pneumonia","volume":"9","author":"Finegold","year":"1991","journal-title":"Rev Infect Dis"},{"key":"R8-6-20240907","first-page":"19","article-title":"Anaerobic bacterial pneumonitis","volume":"119","author":"Bartlett","year":"1979","journal-title":"Am Rev Respir Dis"},{"key":"R9-6-20240907","doi-asserted-by":"crossref","first-page":"329","DOI":"10.7326\/0003-4819-81-3-329","article-title":"Bacteriology of aspiration pneumonia. A prospective study of community- and hospital-acquired cases","volume":"81","author":"Lorber","year":"1974","journal-title":"Ann Intern Med"},{"key":"R10-6-20240907","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1164\/rccm.200212-1543OC","article-title":"Microbiology of severe aspiration pneumonia in institutionalized elderly","volume":"167","author":"El-Solh","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"R12-6-20240907","first-page":"510","article-title":"Risk factors associated with aspiration pneumonia among the patients with drug intoxication","volume":"36","author":"Eizadi-Mood","year":"2018","journal-title":"J Isfahan Med Sch"},{"key":"R13-6-20240907","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/2279-042X.122387","article-title":"Methadone toxicity in a poisoning referral center","volume":"2","author":"Taheri","year":"2013","journal-title":"J Res Pharm Pract"},{"key":"R14-6-20240907","doi-asserted-by":"crossref","first-page":"276","DOI":"10.5455\/msm.2015.27.276-279","article-title":"Clinicalpresentation and the outcome of therapy in a cohort of patients with methadone toxicity in Iran","volume":"27","author":"Eizadi-Mood","year":"2015","journal-title":"Mater Sociomed"},{"key":"R15-6-20240907","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1007\/s00414-020-02412-y","article-title":"Aspiration in lethal drug abuse-aonsequence of opioid intoxication","volume":"134","author":"Nicolakis","year":"2020","journal-title":"Int J Legal Med"},{"key":"R16-6-20240907","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/qjmed\/hcl050","article-title":"Prospective drug utilization evaluation of three broad-spectrum antimicrobials: Cefepime, piperacillin-tazobactam and meropenem","volume":"99","author":"Raveh","year":"2006","journal-title":"QJM: An International Journal of Medicine"}],"container-title":["Journal of Research in Pharmacy Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jrpp.JRPP_21_17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T15:12:45Z","timestamp":1787843565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jrpp.JRPP_21_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/jrpp.jrpp_21_17","relation":{},"ISSN":["2319-9644"],"issn-type":[{"value":"2319-9644","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}