{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T00:50:51Z","timestamp":1793235051525,"version":"4.5.0"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background &amp; objectives:<\/jats:title>\n                    <jats:p>\n                      In 2010, artesunate and sulfadoxine-pyrimethamine (AS+SP) were adopted as the first-line artemisinin based combination therapy for treatment of uncomplicated\n                      <jats:italic toggle=\"yes\">Plasmodium falciparum<\/jats:italic>\n                      malaria in India. Continuous therapeutic efficacy monitoring of first line anti-malarial drugs is required to update the treatment policy for malaria control and elimination. This study aimed to assess the therapeutic efficacy of artesunate and sulfadoxine-pyrimethamine (AS+SP) at three sites with different diseases transmission intensity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A 28-day, single-arm, prospective study was conducted to evaluate the clinical and parasitological response to AS+SP. Patients received a six-dose regimen of AS+SP over three days and were monitored for 28 days through clinical and laboratory assessments. Participant recruitment and outcome classification was done as per WHO guidelines for surveillance of anti-malarial drug efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 170 participants were enrolled and 147 of them completed the follow-up. Adequate clinical and parasitological response (ACPR) was observed in 100% of the study participants who completed the follow-up. 100% fever clearance as well as parasite clearance was observed on day 3.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation &amp; conclusion:<\/jats:title>\n                    <jats:p>\n                      This study demonstrated high therapeutic efficacy and a good safety profile for artesunate and sulfadoxine-pyrimethamine at different transmission intensities. This suggests the continuation of the current artemisinin-based combination therapy for the treatment of\n                      <jats:italic toggle=\"yes\">P. falciparum<\/jats:italic>\n                      malaria in India.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jvbd.jvbd_212_24","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T07:00:10Z","timestamp":1745823610000},"page":"476-481","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and parasitological efficacy of artesunate and sulfadoxine-pyrimethamine (AS+SP) for the treatment of uncomplicated falciparum malaria in different transmission settings in India"],"prefix":"10.4103","volume":"62","author":[{"given":"Ritesh","family":"Ranjha","sequence":"first","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Baharia","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H Chalageri","family":"Vani","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bina","family":"Srivastava","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseem","family":"Ahmed","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Supriya","family":"Sharma","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant Kumar","family":"Mallick","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupkumar R","family":"Anvikar","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Bharti","sequence":"additional","affiliation":[{"name":"ICMR-National Institute of Malaria Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"issue":"3","key":"R2-20251215","doi-asserted-by":"crossref","first-page":"e0264339","DOI":"10.1371\/journal.pone.0264339","article-title":"Therapeutic efficacy of artemether-lumefantrine, arte-sunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: A systematic review and meta-analysis","volume":"17","author":"Marwa","year":"2022","journal-title":"PLoS One"},{"key":"R3-20251215","article-title":"Report on antimalarial drug efficacy, resistance and response: 10 years of surveillance (2010-2019): World Health Organization; 2020. 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