{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:19:45Z","timestamp":1787750385804,"version":"build-2784847793"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n Arboviral diseases in Indonesia remain a public health problem and a threat. The annual increase in cases is caused by changes in bioclimatological factors, increased reports of resistance to insecticides and larvicides, and low community participation in vector control, resulting in an uncontrolled abundance of the species. Therefore, an alternative, safe, effective, and evidence-based vector control approach is needed. This narrative review, conducted via the SANRA protocol encompassing PubMed, Scopus, and Web of Science (2014\u20132024), aims to (1) synthesize current Insect-Specific Flavivirus (ISF) biology, classification, and distribution with emphasis on Indonesia and Southeast Asia; (2) evaluate evidence for ISF-mediated interference with pathogenic flavivirus transmission; (3) compare ISF with Wolbachia-based biocontrol strategies; and (4) identify research priorities and implementation considerations for ISF-based vector control in Indonesia. Eleven articles were further analyzed. Three ISF species (\n cell-fusion agent virus<\/jats:italic>\n ,\n Culex flavivirus<\/jats:italic>\n , and\n Aedes flavivirus<\/jats:italic>\n ) have been detected in Indonesian mosquito populations. Experimental studies have shown that\n Nhumirim virus<\/jats:italic>\n reduces Zika transmission, whereas\n Palm Creek<\/jats:italic>\n virus suppresses\n West Nile virus<\/jats:italic>\n replication.\n The Binjari virus<\/jats:italic>\n -based chimeric vaccine platform produced a good prevention and control model; however, the varying vertical transmission of ISF, lack of field validation, and absence of a regulatory framework are barriers to implementation. However, ISF still requires optimization of population persistence and the development of large-scale application methods. Research priorities include field effectiveness validation, characterization of ISF interactions, and development of standardized release protocols for the translation of ISF technology as a complement to integrated vector control in Indonesia.\n <\/jats:p>","DOI":"10.4103\/jvbd.jvbd_363_25","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T08:00:08Z","timestamp":1782720008000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Insect-Specific Flaviviruses: Novel Strategies for Indonesian Vector-Borne Disease Control"],"prefix":"10.4103","author":[{"given":"I Made Dwi Mertha","family":"Adnyana","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia"},{"name":"Associate Epidemiologists, Indonesian Society of Epidemiologists, Special Capital Region of Jakarta, Indonesia"},{"name":"Royal Society of Tropical Medicine and Hygiene, London, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niken Irfa","family":"Nastiti","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annissa","family":"Delfira","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra Frizki","family":"Asty","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artka Zildzia","family":"Riawan","sequence":"additional","affiliation":[{"name":"Undergraduate Program of Medicine, Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni Luh Gede","family":"Sudaryati","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Information Technology and Science, Universitas Hindu Indonesia, Denpasar, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif Nur Muhammad","family":"Ansori","sequence":"additional","affiliation":[{"name":"Postgraduate School, Universitas Airlangga, Surabaya, Indonesia"},{"name":"Medical Biotechnology Research Group, Virtual Research Center for Bioinformatics and Biotechnology, Surabaya, Indonesia"},{"name":"Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,29]]},"container-title":["Journal of Vector Borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jvbd.jvbd_363_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T12:27:51Z","timestamp":1787747271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jvbd.jvbd_363_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/jvbd.jvbd_363_25","relation":{},"ISSN":["0972-9062"],"issn-type":[{"value":"0972-9062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,29]]},"assertion":[{"value":"2025-12-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}