{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:58:55Z","timestamp":1788901135389,"version":"build-2803163510"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background &amp; objectives:<\/jats:title>\n                    <jats:p>Dengue, a fast-growing vector-borne disease, has an estimated case-fatality rate of 5% and India is largely affected by dengue. Due to its unpredictable course and non-availability of specific treatment, timely identification of risk factors of severe dengue and its management is crucial. This study aimed to evaluate the clinical profile of children admitted to a tertiary care hospital with dengue, including their outcome, and identify the risk factors for severe dengue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This prospective observational study included children admitted with serologically confirmed dengue. World Health Organization classification was used to classify the illness. The details of demographic characteristics, history, clinical examination, laboratory parameters, and outcome were noted. Various risk factors associated with severe dengue, including clinical and laboratory parameters, were determined using crude and adjusted odds ratios at 95% CI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Out of 157 enrolled children, 51 (32.5%) had severe dengue, and 5 (3.2%) died. Severe dengue showed no predilection for age, gender, or baseline IgG positivity. Multivariate-logistic regression analysis identified only fever \u226539\u00b0C [aOR 4.06 (1.60-10.27)] and petechiae [aOR 9.91(3.07-32.03)] as the clinical risk factors for severe dengue. Prolonged prothrombin time (&gt;14s) [aOR 37.21(1.46-946.23)] and platelet count less than 50,000\/cu mm [aOR 12.83(1.12-147.17] were observed as independent laboratory risk factors for severe dengue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation &amp; conclusion:<\/jats:title>\n                    <jats:p>Simple clinical measures like a detailed history of fever &gt;39\u00b0C and examination, especially for petechiae, should caution clinicians against progressing to severe dengue. Along with platelet count, prothrombin time should also be monitored during laboratory investigations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jvbd.jvbd_43_24","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T02:00:09Z","timestamp":1739152809000},"page":"344-350","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Outcome of dengue infection and risk factors for severe dengue in Indian children"],"prefix":"10.4103","volume":"62","author":[{"given":"Neeraj T","family":"Panchanadikar","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali H","family":"Palkar","sequence":"additional","affiliation":[{"name":"Department of Community Medicine, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay K","family":"Lalwani","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Bharati Vidyapeeth (Deemed to be University) Medical College, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"R2-20250915","first-page":"6","article-title":"Outbreak of dengue fever in rural areas of Parbhani district of Maharashtra (India)","volume":"93","author":"Mehendale","year":"1991","journal-title":"The Indian Journal of Medical Research"},{"key":"R7-20250915","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ijid.2021.07.062","article-title":"Risk factors for hospitalization and mortality due to dengue fever in a Mexican population: a retrospective cohort study","volume":"110","author":"Fonseca-Portilla","year":"2021","journal-title":"International Journal of Infectious Diseases"},{"issue":"3","key":"R8-20250915","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/tmi.13968","article-title":"Risk factors associated with severe dengue in Latin America: a systematic review and meta-analysis","volume":"29","author":"Paran\u00e1","year":"2024","journal-title":"Tropical Medicine & International Health"},{"key":"R9-20250915","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1590\/S1020-49892003000500004","article-title":"Dengue severity in the elderly in Puerto Rico","volume":"13","author":"Garc\u00eda-Rivera","year":"2003","journal-title":"Revista Panamericana de Salud P\u00fablica"},{"issue":"8","key":"R10-20250915","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.3201\/eid2908.230014","article-title":"Advanced age and increased risk for severe outcomes of dengue infection, Taiwan, 2014-2015","volume":"29","author":"Huang","year":"2023","journal-title":"Emerging Infectious Diseases"},{"issue":"8","key":"R11-20250915","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/tmi.13797","article-title":"Risk factors for mortality in patients with dengue: A systematic review and meta-analysis","volume":"27","author":"Chagas","year":"2022","journal-title":"Tropical Medicine & International Health"},{"issue":"5","key":"R13-20250915","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jcrc.2011.05.007","article-title":"Clinical profile, intensive care unit course, and outcome of patients admitted in intensive care unit with dengue","volume":"26","author":"Juneja","year":"2011","journal-title":"Journal of Critical Care"},{"issue":"4","key":"R14-20250915","first-page":"237","article-title":"Clinical profile of dengue and predictive severity variables among children at a secondary care hospital of Chilpancingo, Guerrero, Mexico: case series","volume":"73","author":"Alvarado-Castro","year":"2016","journal-title":"Bol Med Hosp InfantMex"},{"issue":"12","key":"R16-20250915","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s12098-017-2423-0","article-title":"The clinical and serological profile of pediatric dengue","volume":"84","author":"Ramabhatta","year":"2017","journal-title":"The Indian Journal of Pediatrics"},{"key":"R17-20250915","first-page":"2016","article-title":"Clinical profile of dengue fever in children: a study from Southern Odisha, India","author":"Mishra","year":"2016","journal-title":"Scientifica"},{"issue":"4","key":"R18-20250915","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s12098-011-0586-7","article-title":"Clinicohematological profile and platelet trends in children with dengue during 2010 epidemic in north India","volume":"79","author":"Mittal","year":"2012","journal-title":"The Indian Journal of Pediatrics"},{"issue":"2","key":"R19-20250915","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12098-014-1523-3","article-title":"Clinical profile of dengue among children according to revised WHO classification: analysis of a 2012 outbreak from Southern India","volume":"82","author":"Sahana","year":"2015","journal-title":"The Indian Journal of Pediatrics"},{"issue":"3","key":"R20-20250915","doi-asserted-by":"crossref","first-page":"115","DOI":"10.4103\/0974-777X.188596","article-title":"Clinically profiling pediatric patients with dengue","volume":"5","author":"Pothapregada","year":"2016","journal-title":"Journal of Global Infectious Diseases"},{"issue":"4","key":"R21-20250915","first-page":"196","article-title":"Clinical profile and outcome of dengue fever and dengue haemorrhagic fever in the paediatric age group with special reference to WHO Guidelines 2012 on fluid management of dengue fever","volume":"3","author":"Bhave","year":"2015","journal-title":"Int J Adv Res"},{"issue":"9","key":"R22-20250915","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1097\/INF.0000000000003179","article-title":"Early predictors of mortality in children with severe dengue fever: A prospective study","volume":"40","author":"Sachdev","year":"2021","journal-title":"The Pediatric Infectious Disease Journal"},{"issue":"6","key":"R23-20250915","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1590\/0037-8682-0036-2018","article-title":"Predictive factors of dengue severity in hospitalized children and adolescents in Rio de Janeiro, Brazil","volume":"51","author":"Ferreira","year":"2018","journal-title":"Rev Soc Bras Med Trop"},{"issue":"6","key":"R24-20250915","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/tropej\/fmr020","article-title":"Risk factors of dengue shock syndrome in children","volume":"57","author":"Gupta","year":"2011","journal-title":"Journal of Tropical Pediatrics"},{"issue":"4","key":"R25-20250915","doi-asserted-by":"crossref","first-page":"e0005498","DOI":"10.1371\/journal.pntd.0005498","article-title":"The value of daily platelet counts for predicting dengue shock syndrome: Results from a prospective observational study of 2301 Vietnamese children with dengue","volume":"11","author":"Lam","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"R26-20250915","first-page":"326","article-title":"Laboratory predictors of dengue shock syndrome during the febrile stage","volume":"41","author":"Chuansumrit","year":"2010","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"10","key":"R27-20250915","doi-asserted-by":"crossref","first-page":"e0009808","DOI":"10.1371\/journal.pntd.0009808","article-title":"Predictive markers for the early prognosis of dengue severity: A systematic review and meta-analysis","volume":"15","author":"Thach","year":"2021","journal-title":"Plos Neglected Tropical Diseases"},{"issue":"1","key":"R28-20250915","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00284-020-02284-w","article-title":"Current understanding of the pathogenesis of dengue virus infection","volume":"75","author":"Bhatt","year":"2021","journal-title":"Current Microbiology"},{"issue":"4","key":"R29-20250915","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s12038-008-0062-3","article-title":"Dengue and dengue haemorrhagic fever: Indian perspective","volume":"33","author":"Chaturvedi","year":"2008","journal-title":"Journal of Biosciences"},{"issue":"8","key":"R30-20250915","doi-asserted-by":"crossref","first-page":"e0009666","DOI":"10.1371\/journal.pntd.0009666","article-title":"Coagulation abnormalities in Dengue fever infection: a systematic review and meta-analysis","volume":"15","author":"Adane","year":"2021","journal-title":"Plos Neglected Tropical Diseases"}],"container-title":["Journal of Vector Borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jvbd.jvbd_43_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:43:10Z","timestamp":1787838190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jvbd.jvbd_43_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jvbd.jvbd_43_24","relation":{},"ISSN":["0972-9062"],"issn-type":[{"value":"0972-9062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]},"assertion":[{"value":"2024-03-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}