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An elaborate understanding of these schemes is mandatory to conceive effective therapeutic strategies. Hence, this review details the landmark paradigms, technical advances and novel clinical interventions pertaining to malaria relapse. Keywords such as \u2018Malaria\u2019, \u2018Vivax Relapse\u2019 and \u2018Hypnozoites\u2019 were selected from PubMed database and data were duly extracted to be synthesized. 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