{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:24:07Z","timestamp":1787840647571,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n                    <jats:title>Background &amp; objectives:<\/jats:title>\n                    <jats:p>Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease and significant health concern particularly in endemic regions. We aimed to evaluate the efficacy in dexamethasone treatment on clinical outcomes in CCHF patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      We included adult patients diagnosed with CCHF and those whose platelet count dropped to 70,000\/mm\n                      <jats:sup>3<\/jats:sup>\n                      or lower. The efficacy of dexamethasone on clinical outcomes was evaluated. It was a retrospective analytical study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All 55 patients received standard supportive treatment, and none of them received ribavirin therapy. It was observed that 23 (41.8%) patients were treated with dexamethasone. No significant differences were observed between patients treated with dexamethasone and without, regarding factors such as bleeding incidents during hospitalization, the need for blood product transfusions, thrombocyte recovery status, intensive care unit admission, and in-hospital mortality. In-hospital mortality was observed in two patients (3.6%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interpretation &amp; conclusion:<\/jats:title>\n                    <jats:p>Our study found that dexamethasone treatment did not lead to a significant improvement in the clinical outcomes for CCHF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jvbd.jvbd_95_24","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T16:03:10Z","timestamp":1750348990000},"page":"181-186","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of dexamethasone therapy in Crimean-Congo hemorrhagic fever in Giresun: An analytical study"],"prefix":"10.4103","volume":"62","author":[{"given":"Sinan","family":"\u00c7etin","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet Melih","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrullah","family":"Ata\u015f","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emsal","family":"Ayd\u0131n","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130lknur","family":"\u015eenel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem Arzu","family":"Yetkin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Clinical Microbiology, Giresun University, Giresun, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"issue":"8","key":"R1-20260422","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1007\/s00705-017-3358-5","article-title":"Changes to taxonomy and the International Code of Virus Classification and Nomenclature ratified by the International Committee on Taxonomy of Viruses 2017","volume":"162","author":"Adams","year":"2017","journal-title":"Arch Virol"},{"issue":"9","key":"R2-20260422","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.3390\/microorganisms9091907","article-title":"Crimean-Congo Hemorrhagic Fever Virus in Asia, Africa and Europe","volume":"9","author":"Shahhosseini","year":"2021","journal-title":"Microorganisms"},{"issue":"8","key":"R3-20260422","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/trstmh\/trv050","article-title":"The global distribution of Crimean-Congo hemorrhagic fever","volume":"109","author":"Messina","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"4","key":"R4-20260422","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S1473-3099(06)70435-2","article-title":"Crimean-Congo haemorrhagic fever","volume":"6","author":"Erg\u04e7n\u00fcl","year":"2006","journal-title":"Lancet Infect Dis"},{"issue":"8","key":"R5-20260422","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.medmal.2019.09.005","article-title":"Crimean-Congo hemorrhagic fever: An update","volume":"49","author":"Fill\u00e2tre","year":"2019","journal-title":"Med Mal Infect"},{"issue":"2","key":"R6-20260422","first-page":"e113427","article-title":"A Systematic Review of Treatment Strategies Including Future Novel Therapies in Crimean-Congo Hemorrhagic Fever","volume":"5","author":"Kouhpayeh","year":"2021","journal-title":"Int J Infect"},{"issue":"9","key":"R7-20260422","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/cid\/cit527","article-title":"Severity scoring index for Crimean-Congo hemorrhagic fever and the impact of ribavirin and corticosteroids on fatality","volume":"57","author":"Dokuzoguz","year":"2013","journal-title":"Clin Infect Dis"},{"issue":"2","key":"R8-20260422","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10096-014-2238-0","article-title":"Validation of a severity grading score (SGS) system for predicting the course of disease and mortality in patients with CrimeanCongo hemorrhagic fever (CCHF)","volume":"34","author":"Bak\u0131r","year":"2015","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"2","key":"R9-20260422","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4103\/0972-9062.213375","article-title":"A new perspective to determine the severity of cases with Crimean-Congo hemorrhagic fever","volume":"49","author":"Bakir","year":"2012","journal-title":"J Vector Borne Dis"},{"issue":"1","key":"R10-20260422","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.antiviral.2007.11.002","article-title":"Treatment of Crimean-Congo hemorrhagic fever","volume":"78","author":"Ergonul","year":"2008","journal-title":"Antiviral Res"},{"issue":"8","key":"R11-20260422","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.eimc.2017.04.007","article-title":"Therapeutic management of Crimean-Congo haemorrhagic fever","volume":"36","author":"De la Calle-Prieto","year":"2018","journal-title":"Enferm Infecc Microbiol Clin"},{"issue":"2","key":"R12-20260422","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1086\/422000","article-title":"Characteristics of patients with Crimean-Congo hemorrhagic fever in a recent outbreak in Turkey and impact of oral ribavirin therapy","volume":"39","author":"Erg\u04e7n\u00fcl","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"12","key":"R13-20260422","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1093\/jac\/dkz328","article-title":"Identification of the crucial parameters regarding the efficacy of ribavirin therapy in Crimean-Congo haemorrhagic fever (CCHF) patients: a systematic review and meta-analysis","volume":"74","author":"Arab-Bafrani","year":"2019","journal-title":"J Antimicrob Chemother"},{"issue":"1","key":"R14-20260422","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jcv.2009.11.007","article-title":"The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey","volume":"47","author":"Koksal","year":"2010","journal-title":"J Clin Virol"},{"issue":"3","key":"R15-20260422","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jinf.2009.01.014","article-title":"Efficacy of oral ribavirin treatment in CrimeanCongo haemorrhagic fever: a quasi-experimental study from Turkey","volume":"58","author":"Elaldi","year":"2009","journal-title":"J Infect"},{"issue":"5","key":"R16-20260422","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s00281-017-0637-x","article-title":"Molecular pathogenesis of viral hemorrhagic fever","volume":"39","author":"Basler","year":"2017","journal-title":"Semin Immunopathol"},{"key":"R17-20260422","doi-asserted-by":"crossref","first-page":"105657","DOI":"10.1016\/j.micpath.2022.105657","article-title":"Recent advances in treatment Crimean-Congo hemorrhagic fever virus: A concise overview","volume":"169","author":"Gholizadeh","year":"2022","journal-title":"Microb Pathog"},{"issue":"3","key":"R18-20260422","doi-asserted-by":"crossref","first-page":"e14587","DOI":"10.5812\/iji.14587","article-title":"Effects of Dexamethasone on Clinical Outcome in Patients with Severe Crimean-Congo Hemorrhagic Fever","volume":"4","author":"Hashemi-Shahri","year":"2017","journal-title":"Int J Infect"},{"issue":"2","key":"R19-20260422","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1177\/0049475513486642","article-title":"Efficacy of high-dose methylprednisolone in patients with Crimean-Congo haemorrhagic fever and severe thrombocytopenia","volume":"43","author":"Sharifi-Mood","year":"2013","journal-title":"Trop Doct"},{"issue":"1","key":"R20-20260422","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1258\/td.2009.090069","article-title":"High-dose methylprednisolone in children with CrimeanCongo haemorrhagic fever","volume":"40","author":"Dilber","year":"2010","journal-title":"Trop Doct"},{"issue":"1","key":"R21-20260422","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1097\/MPH.0b013e3182706444","article-title":"The treatment of crimean-congo hemorrhagic fever with high-dose methylprednisolone, intravenous immunoglobulin, and fresh frozen plasma","volume":"35","author":"Erduran","year":"2013","journal-title":"J Pediatr Hematol Oncol"},{"issue":"3","key":"R22-20260422","doi-asserted-by":"crossref","first-page":"215","DOI":"10.4103\/0972-9062.249479","article-title":"Evaluation of epidemiological, clinical, and laboratory characteristics and mortality rate of patients with CrimeanCongo hemorrhagic fever in the northeast region of Turkey","volume":"55","author":"Karakecili","year":"2018","journal-title":"J Vector Borne Dis"},{"issue":"6","key":"R23-20260422","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1469-0691.2006.01445.x","article-title":"Analysis of risk-factors among patients with Crimean-Congo haemorrhagic fever virus infection: severity criteria revisited","volume":"12","author":"Ergonul","year":"2006","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"R24-20260422","doi-asserted-by":"crossref","first-page":"51","DOI":"10.7883\/yoken.JJID.2014.566","article-title":"Crimean-Congo Hemorrhagic Fever: Prognostic Factors and the Association of Leukocyte Counts with Mortality","volume":"69","author":"Bastug","year":"2016","journal-title":"Jpn J Infect Dis"},{"issue":"1","key":"R25-20260422","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.antiviral.2013.07.007","article-title":"Crimean-Congo hemorrhagic fever in Iran","volume":"100","author":"Keshtkar-Jahromi","year":"2013","journal-title":"Antiviral Res"},{"key":"R26-20260422","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.2147\/IDR.S410955","article-title":"Clinical and Epidemiological Characteristics of 30 Fatal Cases of Crimean-Congo Hemorrhagic Fever in Kabul, Afghanistan: A Retrospective Observational Study","volume":"16","author":"Rasikh","year":"2023","journal-title":"Infect Drug Resist"},{"issue":"7","key":"R27-20260422","doi-asserted-by":"crossref","first-page":"e96","DOI":"10.1086\/521244","article-title":"Viral load as a predictor of outcome in Crimean-Congo hemorrhagic fever","volume":"45","author":"Cevik","year":"2007","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Vector Borne Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/JVBD.JVBD_95_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:27Z","timestamp":1787837187000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/JVBD.JVBD_95_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jvbd.jvbd_95_24","relation":{},"ISSN":["0972-9062"],"issn-type":[{"value":"0972-9062","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-05-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-18","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}