{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:39:08Z","timestamp":1787841548347,"version":"build-2784847793"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["JWAS"],"published-print":{"date-parts":[[2024,7]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n \n Gastro-duodenal perforation is a common surgical emergency that remains a formidable health burden worldwide with significant morbidity and mortality. Ulcer disease remains the most common cause of gastro-duodenal perforation. Diagnosing the presence of\n H. pylori<\/jats:italic>\n can help eradicate the infection from the community at large and thereby reduce the chances of gastro-duodenal perforation.\n <\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n \n To assess the clinical presentation of gastro-duodenal perforation patients and to evaluate the detection of\n Helicobacter pylori<\/jats:italic>\n infection by available investigations.\n <\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A descriptive observational study was conducted among 80 patients presenting with clinical features suggestive of gastro-duodenal perforation and confirmed by clinical, radiological basis and operative findings admitted at a rural tertiary care hospital during 2019-2020. Detailed history was taken from the patient\/party, clinically examined, and blood\/tissue samples were investigated. The patients were managed with standard treatment modality in the studied institute. Data were collected, compiled, and entered MS Excel and analyzed using appropriate software. Descriptive analysis was done in the form of proportion for categorical variables, mean or median for continuous variables.<\/jats:p>\n <\/jats:sec>\n \n Result:<\/jats:title>\n \n Cases of gastro-duodenal perforations were more among middle to later age of life, mostly affecting married male patients hailed from rural area and unskilled workers. History of intake of spicy food, prolonged starvation, history of NSAID use were common among them. Majority of the patients had history of pain abdomen in the past suggesting of PUD and history of taking variety group of acid reducing agents. Most of them presented with epigastric pain, vomiting, abdominal distension along with other signs of peritonitis. Obliteration of liver dullness and free gas under right dome of diaphragm was also noted in large proportion among them. Majority of cases were found positive for\n H. pylori<\/jats:italic>\n on Histology (85%), followed by rapid urease test (RUT) (80%) and a positivity of 72.5% and 68.8% on serum IgG and IgA antibody respectively. Rapid Urease Test was more sensitive as well as specific in diagnosing of\n H. pylori<\/jats:italic>\n than antibody detection test.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Early detection of\n H. pylori<\/jats:italic>\n infection and treatment with potent anti\n H. pylori<\/jats:italic>\n therapy postoperatively has been found to be adequate.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jwas.jwas_140_23","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T12:59:29Z","timestamp":1723121969000},"page":"289-294","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Profile of gastroduodenal perforation patients admitted in a rural tertiary care hospital: An observational cross-sectional study"],"prefix":"10.4103","volume":"14","author":[{"given":"Gourab","family":"Bose","sequence":"first","affiliation":[{"name":"Department of Surgery and Community Medicine, North Bengal Medical College and MJN Medical College, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Ray","sequence":"additional","affiliation":[{"name":"Department of Surgery and Community Medicine, North Bengal Medical College and MJN Medical College, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shah Nawaz","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Surgery and Community Medicine, North Bengal Medical College and MJN Medical College, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaushik","family":"Ishore","sequence":"additional","affiliation":[{"name":"Department of Surgery and Community Medicine, North Bengal Medical College and MJN Medical College, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"key":"CIT0001-20240907","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s002689910045","article-title":"Trends in perforated peptic ulcer: Incidence, etiology, treatment, and prognosis","volume":"24","author":"Svanes","year":"2000","journal-title":"World J Surg"},{"key":"CIT0002-20240907","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000264653","article-title":"Perforated peptic ulcer disease: A review of history and treatment","volume":"27","author":"Bertleff","year":"2010","journal-title":"Dig Surg"},{"key":"CIT0003-20240907","first-page":"454","article-title":"Surgical management of peptic ulcer disease","volume":"79","author":"Kuremu","year":"2002","journal-title":"East Afr Med J"},{"key":"CIT0004-20240907","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4314\/njm.v17i4.37421","article-title":"Experience with acute perforated duodenal ulcer in a West African population","volume":"17","author":"Nuhu","year":"2008","journal-title":"Niger J Med"},{"key":"CIT0005-20240907","first-page":"9","article-title":"Perforated peptic ulcer in Tikur Anbessa Hospital: A review of 74 cases","volume":"43","author":"Ersumo","year":"2005","journal-title":"Ethiop Med J"},{"key":"CIT0006-20240907","first-page":"205","article-title":"Perforated gastric and duodenal ulcers in an urban African population","volume":"25","author":"Ohene-Yeboah","year":"2006","journal-title":"West Afr J Med"},{"key":"CIT0007-20240907","first-page":"41","article-title":"Pattern of change in the frequency of Helicobacter pylori with perforated duodenal ulcer","volume":"20","author":"Aman","year":"2008","journal-title":"J Ayub Med Coll Abbottabad"},{"key":"CIT0008-20240907","first-page":"79","article-title":"Selected socio-economic features and the prevalence of peptic ulcer among Polish rural population","volume":"9","author":"Schabowski","year":"2002","journal-title":"Ann Agric Environ Me"},{"key":"CIT0009-20240907","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15218\/zjms.2009.001","article-title":"\u201cRisk factors for acute perforated duodenal ulcers in Erbil Governorate-Kurdistan, Iraq","volume":"13","author":"Zangana","year":"2009","journal-title":"Zanco J Med Sci"},{"key":"CIT0010-20240907","first-page":"47","article-title":"A clinico-pathological study of duodenal ulcer perforation and its management in a rural area in Karnataka","volume":"2","author":"Koliwad Pavan Kumar","year":"2013","journal-title":"Int J Med Appl Sci"},{"key":"CIT0012-20240907","first-page":"19","article-title":"Retrospective study of perforated peptic ulcer: A surgical emergency","volume":"4","author":"Mathur","year":"2017","journal-title":"Int Surg J"},{"key":"CIT0013-20240907","first-page":"120","article-title":"Study of incidence of peptic ulcer perforation in young adults: A hospital based study","volume":"4","author":"Sarda","year":"2018","journal-title":"Int Arch Biomed Clin Res"},{"key":"CIT0014-20240907","doi-asserted-by":"crossref","first-page":"22S","DOI":"10.1016\/0002-9343(92)90623-J","article-title":"Smoking and wound healing","volume":"93","author":"Silverstein","year":"1992","journal-title":"Am J Med"},{"key":"CIT0015-20240907","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1015-9584(09)60018-X","article-title":"Perforated peptic ulcer: Different ethnic, climatic and fasting risk factors for morbidity in Al-ain medical district, United Arab Emirates","volume":"32","author":"Torab","year":"2009","journal-title":"Asian J Surg"},{"key":"CIT0016-20240907","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/00000658-198906000-00006","article-title":"All perforated ulcers are not alike","volume":"209","author":"Horowitz","year":"1989","journal-title":"Ann Surg"},{"key":"CIT0017-20240907","first-page":"540","article-title":"A study on peptic perforation at SP Medical College and PBM & associated group of hospitals, Bikaner-Rajasthan","volume":"6","author":"Sharma","year":"2017","journal-title":"Indian J Basic Appl Med Res"},{"key":"CIT0018-20240907","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.ijsu.2008.12.037","article-title":"Definitive or conservative surgery for perforated gastric ulcer?\u2014An unresolved problem","volume":"7","author":"Sarath Chandra","year":"2009","journal-title":"Int J Surg"},{"key":"CIT0019-20240907","first-page":"308","article-title":"Drug utilisation study in a tertiary care center: Recommendations for improving hospital drug dispensing policies","volume":"76","author":"Mittal","year":"2014","journal-title":"Indian J Pharm Sci"},{"key":"CIT0020-20240907","first-page":"36","article-title":"Presentation and management of perforated peptic ulcer disease in a Tertiary Centre in South Nigeria","volume":"5","author":"Dodiyi-Manuel","year":"2015","journal-title":"J West Afr Coll Surg"},{"key":"CIT0021-20240907","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4103\/0975-2870.126331","article-title":"Helicobacter pylori in gastroduodenal perforation","volume":"7","author":"Dogra","year":"2014","journal-title":"Med J Dr DY Patil Univ"},{"key":"CIT0022-20240907","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/bjs.1800820325","article-title":"Helicobacter pylori infection in perforated peptic ulcer disease","volume":"82","author":"Sebastian","year":"1995","journal-title":"Br J Surg"},{"key":"CIT0023-20240907","first-page":"1191","article-title":"Usefulness of the combined IgG and IgA antibody determinations for serodiagnosis of Helicobacter pylori infection","volume":"9","author":"Mart\u00edn-de-Argila","year":"1997","journal-title":"Eur J Gastroenterol Hepatol"}],"container-title":["Journal of West African College of Surgeons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_140_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:01:05Z","timestamp":1787839265000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_140_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/jwas.jwas_140_23","relation":{},"ISSN":["2276-6944"],"issn-type":[{"value":"2276-6944","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5,24]]},"assertion":[{"value":"2023-07-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}