{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:30Z","timestamp":1787169870173,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Full-thickness rectal biopsy is often used for the diagnosis of Hirschsprung\u2019s disease (where a suction biopsy kit is not available). This is associated with some challenges such as limited theatre space and the need for general anaesthesia. We aim to highlight the usefulness and sensitivity of a modification of the rectal mucosal biopsy without general anaesthesia in the diagnosis of Hirschsprung\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This is a retrospective analysis of children with Hirschsprung\u2019s disease who had rectal mucosal biopsy over a 16-year period (January 2004\u2013December 2019). Research was approved with institutional number ABUTHZ\/HREC\/H22\/2022. The patients had the biopsy with small, curved artery forceps, surgical blade, and dissecting scissors. Histological analyses of tissue were done. Clinical data and results were recorded on a structured\n                      <jats:italic toggle=\"yes\">pro forma<\/jats:italic>\n                      , and the data were analysed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 263 boys and 97 girls with a median age of 10.5 months. Only 37 (10.3%) of the rectal biopsies were done by consultants. Hirschsprung\u2019s disease was confirmed in 279 (75.5%) of the partial-thickness biopsies, whereas 52 (14.4%) biopsies were inadequate specimens. Resident doctors were responsible for 92.2% (47) of inadequate biopsies (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.63), although they did 89.7% of all biopsies. In one (0.3%) patient, the procedure ended as a full-thickness biopsy leading to a significant haemorrhage that required blood transfusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The modified rectal mucosal biopsy is a simple, safe, and effective method for making the diagnosis of Hirschsprung\u2019s disease. This is performed without general anaesthesia and is useful where a suction biopsy kit is unavailable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jwas.jwas_241_22","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:41:45Z","timestamp":1694760105000},"page":"36-39","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A Modified Rectal Mucosal Biopsy for the Diagnosis of Hirschsprung\u2019s Disease"],"prefix":"10.4103","volume":"13","author":[{"given":"Tunde Talib","family":"Sholadoye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halima Oziohu","family":"Aliyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Mari","family":"Mshelbwala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240907","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0022-3468(69)90606-X","article-title":"A rectal suction biopsy tube for use in the diagnosis of Hirschsprung\u2019s disease","volume":"4","author":"Noblett","year":"1969","journal-title":"J Pediatr Surg"},{"key":"R2-5-20240907","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12519-015-0068-5","article-title":"Rectal biopsy for Hirschsprung\u2019s disease: A review of techniques, pathology, and complications","volume":"12","author":"Muise","year":"2016","journal-title":"World J Pediatr"},{"key":"R3-5-20240907","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/01.XPS.0000445130.82852.0D","article-title":"Experience with full-thickness rectal biopsy in the evaluation of patients with suspected Hirschsprung\u2019s disease","volume":"10","author":"Bamigbola","year":"2014","journal-title":"Ann Pediatric Surg"},{"key":"R4-5-20240907","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jpedsurg.2016.02.064","article-title":"Suction rectal biopsy yields adequate tissue in children","volume":"51","author":"Brady","year":"2016","journal-title":"J Pediatr Surg"},{"key":"R5-5-20240907","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/0022-3468(93)90703-N","article-title":"The simple technique of rectal mucosal biopsy for the diagnosis of Hirschsprung\u2019s disease","volume":"28","author":"Hirose","year":"1993","journal-title":"J Pediatr Surg"},{"key":"R6-5-20240907","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.jpedsurg.2019.03.010","article-title":"Guidelines for synoptic reporting of surgery and pathology in Hirschsprung disease","volume":"54","author":"Veras","year":"2019","journal-title":"J Pediatr Surg"},{"key":"R7-5-20240907","first-page":"100","article-title":"Effectiveness of rectal suction biopsy in diagnosing Hirschsprung disease","volume":"26","author":"Keyzer-Dekker","year":"2016","journal-title":"Eur J Pediatr Surg"},{"key":"R8-5-20240907","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.jss.2015.10.031","article-title":"A comparison of suction and full-thickness rectal biopsy in children","volume":"201","author":"Muise","year":"2016","journal-title":"J Surg Res"},{"key":"R9-5-20240907","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1007\/s00383-016-3907-0","article-title":"Current practice patterns of rectal suction biopsy in the diagnostic work-up of Hirschsprung\u2019s disease: Results from an international survey","volume":"32","author":"Friedmacher","year":"2016","journal-title":"Pediatr Surg Int"},{"key":"R10-5-20240907","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00383-015-3742-8","article-title":"Rectal suction biopsy for the diagnosis of Hirschsprung\u2019s disease: A systematic review of diagnostic accuracy and complications","volume":"31","author":"Friedmacher","year":"2015","journal-title":"Pediatr Surg Int"},{"key":"R11-5-20240907","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1590\/S1676-24442005000600010","article-title":"The accuracy of acetylcholinesterase reaction in rectal suction biopsy in the diagnosis of Hirschsprung\u2019s disease","volume":"41","author":"Gugelmin","year":"2005","journal-title":"J Bras Patol Med Lab"},{"key":"R12-5-20240907","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4236\/ss.2014.51004","article-title":"A comparison of rectal suction and full wall biopsy in Hirschsprung\u2019s disease","volume":"5","author":"Ax","year":"2014","journal-title":"Surg Sci"},{"key":"R13-5-20240907","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s003830050264","article-title":"Rectal biopsy for Hirschsprung\u2019s disease: What is the optimum method?","volume":"13","author":"Alizai","year":"1998","journal-title":"Pediatr Surg Int"},{"key":"R14-5-20240907","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/01.mpg.0000252188.12793.ee","article-title":"At what age is a suction rectal biopsy less likely to provide adequate tissue for identification of ganglion cells?","volume":"44","author":"Croffie","year":"2007","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Journal of West African College of Surgeons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_241_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:14:19Z","timestamp":1787166859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_241_22"}},"subtitle":["Zaria Experience"],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/jwas.jwas_241_22","relation":{},"ISSN":["2276-6944"],"issn-type":[{"value":"2276-6944","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}