{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:25:41Z","timestamp":1787840741898,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T00:00:00Z","timestamp":1725235200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J West Afr Coll Surg"],"published-print":{"date-parts":[[2025,7]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Chordomas are rare tumours of presumptive notochordal origin, mostly occurring in the axial skeleton of the body. These tumours are slow growing but are locally invasive neoplasms. Diagnosis requires qualification of the radiological, histopathological, and immunohistochemical criteria. Management predominantly comprises surgical resection with negative margins.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n Our study aimed to analyse the clinico-pathological spectrum of these rare chordoma cases visiting our tertiary care institute.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n The study was retrospective, comprising chordoma cases reported histopathologically between January 01, 2013, and August 31, 2023 (a total period of 10.5 years). Clinico-radiological data were recorded. Histopathological diagnosis was separately reviewed by two pathologists. All data were statistically analysed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n In total, 41 chordoma cases were received, with a mean age of 43.2\u2009+\u200917.4 years (6\u201372 years). Male:female ratio was 1.2:1. Spheno-occipital region chordomas (27 cases) were most common, followed by sacrococcygeal (8 cases) and vertebral (6 cases) chordomas. Symptoms varied with location. However, the commonest presenting complaint was pain. These region-wise chordoma categories were statistically compared in terms of patients\u2019 age, male:female ratio, symptomatic duration, tumour size, histopathological tumour type, and recurrence on follow-up. Of these, only patients\u2019 age and tumour size were found to be statistically significant (\n P<\/jats:italic>\n value was 0.011 and 0.0004, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Clinico-pathological parameters vary with the anatomical location of chordoma. We present the experience of this rare tumour in terms of clinico-radiopathological features visiting our tertiary care institute in northern India.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/jwas.jwas_27_24","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T05:02:45Z","timestamp":1725512565000},"page":"245-251","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Chordoma: Site-Wise Predilections and Pathological Tenets"],"prefix":"10.4103","volume":"15","author":[{"given":"Anshima","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram Nawal","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash","family":"Billore","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Post Graduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,2]]},"reference":[{"key":"CIT0001-20250613","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ejca.2012.09.011","article-title":"Descriptive epidemiology of sarcomas in Europe: Report from the RARECARE project","volume":"49","author":"Stiller","year":"2013","journal-title":"Eur J Cancer"},{"key":"CIT0003-20250613","doi-asserted-by":"crossref","first-page":"348","DOI":"10.25259\/SNI_507_2022","article-title":"Indolent multicentric chordoma\u2014A previously undescribed entity: A Case report and literature review","volume":"13","author":"Jenson","year":"2022","journal-title":"Surg Neurol Int"},{"key":"CIT0004-20250613","first-page":"700","article-title":"Clinicopathological characteristics of chordoma: An institutional experience and a review of the literature","volume":"23","author":"Makhdoomi","year":"2013","journal-title":"Turk Neurosurg"},{"key":"CIT0005-20250613","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s13256-018-1784-y","article-title":"Chordoma: A case series and review of the literature","volume":"12","author":"Alan","year":"2018","journal-title":"J Med Case Rep"},{"key":"CIT0006-20250613","doi-asserted-by":"crossref","first-page":"153089","DOI":"10.1016\/j.prp.2020.153089","article-title":"Chordomas: A review with emphasis on their pathophysiology, pathology, molecular biology, and genetics","volume":"216","author":"Karpathiou","year":"2020","journal-title":"Pathol Res Pract"},{"key":"CIT0007-20250613","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11912-011-0176-x","article-title":"Systemic therapy options for unresectable and metastatic chordomas","volume":"13","author":"Stacchiotti","year":"2011","journal-title":"Curr Oncol Rep"},{"key":"CIT0008-20250613","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1080\/10790268.2018.1483593","article-title":"Surgical management of chordoma: A systematic review","volume":"43","author":"Denaro","year":"2020","journal-title":"J Spinal Cord Med"},{"key":"CIT0009-20250613","doi-asserted-by":"crossref","first-page":"422","DOI":"10.3171\/2017.7.SPINE17668","article-title":"A historical recount of chordoma","volume":"28","author":"Sahyouni","year":"2018","journal-title":"J Neurosurg Spine"},{"key":"CIT0010-20250613","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1007\/s00586-018-5764-0","article-title":"Chordoma: A systematic review of the epidemiology and clinical prognostic factors predicting progression-free and overall survival","volume":"27","author":"Bakker","year":"2018","journal-title":"Eur Spine J"}],"container-title":["Journal of West African College of Surgeons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_27_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:28:05Z","timestamp":1787837285000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_27_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,2]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jwas.jwas_27_24","relation":{},"ISSN":["2276-6944","2992-5827"],"issn-type":[{"value":"2276-6944","type":"print"},{"value":"2992-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,2]]},"assertion":[{"value":"2024-02-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}