{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:17:43Z","timestamp":1787840263850,"version":"build-2784847793"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:00:00Z","timestamp":1724371200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J West Afr Coll Surg"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ocular surface squamous cell neoplasia can arise from a premalignant lesion (conjunctival intraepithelial neoplasia or ocular surface squamous cell intraepithelial neoplasia). Their respective magnitudes will provide an indication of early treatment or progression of the disease. This study, therefore, aims to determine the frequency of premalignant and malignant ocular surface squamous neoplasia. This is a retrospective study of all cases of premalignant and malignant ocular surface squamous neoplastic lesions histologically diagnosed over an 18-year period at the Department of Anatomic Pathology, University of Benin Teaching Hospital. The results showed that there were more malignant ocular surface squamous neoplastic lesions relative to ocular surface squamous cell intraepithelial neoplastic lesions. Also, the latter occurs at a relatively lower median age in comparison to the former. In conclusion, our findings suggest that late presentation of symptoms may account for higher frequency of malignant ocular surface squamous neoplastic lesions.<\/jats:p>","DOI":"10.4103\/jwas.jwas_6_24","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T17:14:59Z","timestamp":1724433299000},"page":"265-268","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Premalignant and Malignant Ocular Surface Squamous Cell Neoplasia: A Retrospective Hospital-Based Study Spanning 18 Years"],"prefix":"10.4103","volume":"15","author":[{"given":"Dumebi Hedwig","family":"Kayoma","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, University of Benin, Benin City, Edo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dele Eradebamwen","family":"Imasogie","sequence":"additional","affiliation":[{"name":"Department of Anatomic Pathology, University of Benin Teaching Hospital, Benin City, Edo State, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,8,23]]},"reference":[{"key":"CIT0004-20250613","first-page":"232","article-title":"Histopathology of ocular tumor specimens in Benin City, Nigeria","volume":"4","author":"Aghogho Akpe","year":"2009","journal-title":"J Ophthalmic Vis Res"},{"key":"CIT0005-20250613","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4314\/ahs.v22i3.23","article-title":"Histopathological pattern of Orbito-Ocular Lesions, a retrospective hospital-based study spanning 15 years","volume":"22","author":"Kayoma","year":"2021","journal-title":"Afr Health Sci"},{"key":"CIT0006-20250613","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/619414","article-title":"Morphological spectrum of Orbitoocular diseases in a tertiary health centre in Keffi, North Central Nigeria","volume":"2015","author":"Onwubuya","year":"2015","journal-title":"Adv Med"},{"key":"CIT0007-20250613","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3126\/jcmc.v3i2.8442","article-title":"A clinico-histopathological study of orbital and ocular lesions; A multicenter study","volume":"3","author":"Bastola","year":"2013","journal-title":"J Chitwan Med Coll"},{"key":"CIT0008-20250613","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/1117-1936.181043","article-title":"Orbito-ocular lesions in Lagos","volume":"15","author":"Anunobi","year":"2008","journal-title":"Niger Postgrad Med J"},{"key":"CIT0009-20250613","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4103\/1118-8561.134485","article-title":"A study of the histopathologic pattern of orbito-ocular disease in a tertiary hospital in Nigeria","volume":"17","author":"Charles","year":"2014","journal-title":"Sahel Med J"},{"key":"CIT0010-20250613","first-page":"145","article-title":"A clinico-pathological study of orbito-ocular tumors at Ahmadu Bello University Teaching Hospital, Shika-Zaria, Nigeria: A 5-year review","volume":"21","author":"Chinda","year":"2012","journal-title":"Clin Cancer Investig J"},{"key":"CIT0011-20250613","first-page":"9","article-title":"Clinico-pathological spectrum of ophthalmic lesions: An experience in tertiary care hospital of Central India","volume":"11","author":"Gupta","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"CIT0012-20250613","first-page":"39","article-title":"Clinico-histopathological analysis of orbitoocular lesions: A hospital-based study","volume":"6","author":"Kafle","year":"2019","journal-title":"JPAHS"},{"key":"CIT0013-20250613","doi-asserted-by":"crossref","first-page":"23","DOI":"10.4103\/0331-8540.102109","article-title":"A pathologic review of ophthalmic tumors in Kano, Northern Nigeria","volume":"9","author":"Umar","year":"2012","journal-title":"Niger J Basic Clin Sci"},{"key":"CIT0014-20250613","first-page":"58","article-title":"Histoplathological features of Tumours in the Orbit and Adnexia seen in Korle-Bu Teaching Hospital","volume":"31","author":"Ackuaku-Dogbe","year":"2012","journal-title":"WAJM"},{"key":"CIT0015-20250613","first-page":"133","article-title":"A histopathological study of ophthalmic lesions at a teaching hospital","volume":"2","author":"Chauhan","year":"2012","journal-title":"National J Med Res"},{"key":"CIT0016-20250613","first-page":"108","article-title":"The tale of retinoblastoma seen in a tertiary health centre; a 13 year study","volume":"29","author":"Imasogie","year":"2019","journal-title":"Nig Qt J Hosp Med"}],"container-title":["Journal of West African College of Surgeons"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_6_24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:18:51Z","timestamp":1787836731000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/jwas.jwas_6_24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,23]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/jwas.jwas_6_24","relation":{},"ISSN":["2276-6944","2992-5827"],"issn-type":[{"value":"2276-6944","type":"print"},{"value":"2992-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,23]]},"assertion":[{"value":"2024-01-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}