{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:37:01Z","timestamp":1787071021177,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T00:00:00Z","timestamp":1757116800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["J West Afr Coll Surg"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Living renal donors do not usually undergo preoperative hydration, which may cause subclinical graft renal injury. We planned a prospective randomised study to determine the effect of preoperative renal donor hydration on intraoperative graft parameters, neutrophil gelatinase-associated lipocalin (NGAL) levels, and other complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Living donor renal transplantation pairs were randomised into two groups: Group 1 donors (controls) were fasting overnight with no hydration from 11\n                      <jats:sc>pm<\/jats:sc>\n                      to 7\n                      <jats:sc>am<\/jats:sc>\n                      , while Group 2 donors were fasting with preoperative hydration (2 L of intravenous Ringer\u2019s lactate) from 11\n                      <jats:sc>pm<\/jats:sc>\n                      to 7\n                      <jats:sc>am<\/jats:sc>\n                      . The primary outcome parameter was positive graft ischaemia (PGI), deemed positive when at least two were present: visible graft discolouration, renal arterial spasm, reduction in urine output before and after division of ureter, and, flaccidity of the graft.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The two groups were comparable in demographic, clinical parameters including graft function. PGI was present in 7\/32 (22%), with no significant differences between the groups. Mean NGAL levels were lower in Group 2 without statistical significance. There was a significant correlation between PGI and proportion of functional delayed graft function (85% versus 36%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03), but not between of PGI and warm ischaemia time (WIT \u2013 55.57 \u00b1 10.86\u2009min vs 50.32 \u00b1 13.14;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.342), cold ischaemia time (CIT \u2013 32.14 \u00b1 9.12 vs 26.53 \u00b1 11.58;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.204), or mean urinary NGAL (30.67 \u00b1 1.97 ng\/mL versus 28.67 \u00b1 2.65 ng\/mL;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Preoperative donor hydration may decrease perioperative subclinical renal injury, but more studies with larger sample size are required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jwas.jwas_7_25","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T10:01:50Z","timestamp":1757412110000},"page":"158-166","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Preoperative Donor Hydration on Outcomes in Living Donor Renal Transplantation: A Prospective Randomised Study"],"prefix":"10.4103","volume":"16","author":[{"given":"Revanth Kumar Reddy","family":"Pothapi","sequence":"first","affiliation":[{"name":"Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital (RMLH), New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalit","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital (RMLH), New Delhi, Delhi, India"},{"name":"Department of Surgery, ESI Hospital and PG Institute, Faridabad, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyan Ranjan","family":"Kumar","sequence":"additional","affiliation":[{"name":"Transplant Unit, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital (RMLH), New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Dokania","sequence":"additional","affiliation":[{"name":"Transplant Unit, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital (RMLH), New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplant, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital (RMLH), New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitin","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Transplant Unit, Department of Surgery, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital (RMLH), New Delhi, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,6]]},"reference":[{"key":"CIT0001-20260318","doi-asserted-by":"crossref","first-page":"71","DOI":"10.25259\/ANAMS_TFR_02_2024","article-title":"NAMS task force report on Organ donation and transplantation","volume":"60","year":"2024","journal-title":"Ann Natl Acad 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