{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:04:52Z","timestamp":1787169892725,"version":"build-2736575974"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Post-operative pain treatment is a major challenge in our environment. Opioids may cause respiratory depression post-operatively. Therefore, any combination of opioid and non-opioid analgesics that provides quality post-operative pain control and reduces opioid consumption with its attendant side effects will be highly desirable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The aim of this article is to evaluate analgesic benefits and opioid-sparing effects of pre-operative oral pregabalin in patients who undergo abdominal gynaecological surgeries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A prospective randomized double-blind placebo-controlled study is carried out at University of Ilorin Teaching Hospital, Kwara State, Nigeria. Eighty-two patients scheduled for gynaecological surgeries were randomized into two equal groups. The patients in the control and study groups received a placebo drug and oral pregabalin 150 mg, respectively, 1 h before induction of general anaesthesia. Post-operative pain intensity using a five-point Verbal Rating Scale, time to first request for analgesia, and 24 h post-operative pethidine consumptions were assessed. Mean values were compared using Student\u2019s\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test. Categorical data were compared with the\n                      <jats:italic toggle=\"yes\">\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      test. Level of significance was set at 5% (0.05) and power of the study was 80%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Demographic characteristics were comparable between the two groups. The median pain score was 0\u20132 (no pain\u2013moderate pain) throughout the study. Post-operative static and dynamic pain scores at 1, 4, and 12 h were significantly higher in the placebo group (&lt;0.001). Twenty-four hours post-operatively, there were no significant differences in static and dynamic pain scores between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.131 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.384, respectively). Time to first analgesic requirement and total pethidine consumed within 24 h post-operative were 47\u2009\u00b1\u200919 vs. 258\u2009\u00b1\u2009137 min (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001) and 326.19\u2009\u00b1\u200962.70 vs. 192.86\u2009\u00b1\u200955.84 mg (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.001) in the control and study groups, respectively. The pre-operative use of pregabalin reduced post-operative opioid requirement by 40.9% in the study group. Nausea and vomiting were more common in the placebo group, whereas dizziness, blurring of vision, and sedation were more common in the pregabalin group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A single pre-operative dose of 150 mg oral pregabalin had significantly greater analgesic effects compared with placebo and reduced post-operative opioid requirements in patients undergoing myomectomy or total abdominal hysterectomy. It should be considered an adjuvant in multimodal pain management regimens following gynaecological surgeries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/jwas.jwas_802_22","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T06:37:17Z","timestamp":1694759837000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Post-operative Analgesic and Opioid-sparing Effect of a Single-dose Pre-operative Oral Pregabalin in Gynaecological Surgeries"],"prefix":"10.4103","volume":"12","author":[{"given":"K. Adewale","family":"Adegboye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. K.","family":"Kolawole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. O.","family":"Bolaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. A.","family":"Suleiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. B.","family":"Adegboye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20240907","first-page":"305","article-title":"Postoperative pain management following caesarean section in University of Ilorin Teaching Hospital (UITH), Ilorin, Nigeria","volume":"22","author":"Kolawole","year":"2003","journal-title":"West Afr J Med"},{"key":"R2-1-20240907","first-page":"11","article-title":"Recent advances in postoperative pain management","volume":"83","author":"Vadivelu","year":"2010","journal-title":"Yale J Biol Med"},{"key":"R3-1-20240907","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/AAP.0b013e3181fa6b7a","article-title":"Can a single dose of 300\u2009mg of pregabalin reach acute antihyperalgesic levels in the central nervous system?","volume":"35","author":"Buvanendran","year":"2010","journal-title":"Reg Anesth Pain Med"},{"key":"R4-1-20240907","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/bja\/aen244","article-title":"Evaluation of a single preoperative dose of pregabalin for attenuation of postoperative pain after laparoscopic cholecystectomy","volume":"101","author":"Agarwal","year":"2008","journal-title":"Br J Anaesth"},{"key":"R5-1-20240907","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0013-9580.2004.455003.x","article-title":"Pregabalin pharmacology and its relevance to clinical practice","volume":"45","author":"Ben-Menachem","year":"2004","journal-title":"Epilepsia"},{"key":"R6-1-20240907","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1399-6576.2008.01821.x","article-title":"Pregabalin and dexamethasone in combination with paracetamol for postoperative pain control after abdominal hysterectomy. 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