{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:41Z","timestamp":1787840561802,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"130","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Objective:<\/jats:bold>\n To analyse the effects of noise exposure in emergency resuscitation rooms (ERRs) on cognitive function and hyperalgesia in patients with trauma.\n Methods:<\/jats:bold>\n Clinical data from 110 patients with trauma who were treated in the ERR of Suizhou Central Hospital between June 2022 and July 2023 were retrospectively analysed. Participants were divided into the following two groups on the basis of real-time noise monitoring: the high-noise-exposure (\n n<\/jats:italic>\n \u2009=\u200985) and low-noise-exposure (\n n<\/jats:italic>\n \u2009=\u200925) groups. Neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), homocysteine (Hcy), the Mini-Mental State Examination (MMSE), and the Montreal Cognitive Assessment (MoCA) were used to measure cognitive performance. Mechanical pain threshold and serum nerve growth factor (NGF), substance P (SP), calcitonin gene-related peptide (CGRP) and 5-hydroxytryptamine (5-HT) levels were applied to assess hyperalgesia. Pearson correlation was employed to investigate the connections between noise levels and outcome factors.\n Results:<\/jats:bold>\n The high-noise-exposure group demonstrated significantly lower MMSE scores, MoCA scores and serum BDNF levels but higher serum NSE and Hcy levels compared with the low-noise-exposure group (\n P<\/jats:italic>\n < 0.05). Additionally, compared with the low-noise-exposure group, the high-noise-exposure group exhibited larger mechanical hyperalgesia areas around incisions and on the volar forearm, as well as elevated serum CGRP, NGF and SP levels, while showing reduced mechanical pain thresholds and lower serum 5-HT levels (\n P<\/jats:italic>\n < 0.05). Pearson analysis revealed that noise exposure values had negative correlations with mechanical pain threshold, MMSE and MoCA scores and serum BDNF and 5-HT levels (\n r<\/jats:italic>\n < 0,\n P<\/jats:italic>\n < 0.05) but positive correlations with mechanical hyperalgesia area and serum CGRP, NSE, Hcy, NGF and SP levels (\n r<\/jats:italic>\n > 0,\n P<\/jats:italic>\n < 0.05).\n Conclusion:<\/jats:bold>\n High noise exposure in ERRs may be associated with cognitive dysfunction and hyperalgesia in patients with trauma. Clinical management should recognise and control noise levels in these settings.\n <\/jats:p>","DOI":"10.4103\/nah.nah_121_25","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T12:00:24Z","timestamp":1773057624000},"page":"54-61","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effects of Noise Exposure in Emergency Resuscitation Rooms on Cognitive Function and Hyperalgesia in Patients with Trauma: A Retrospective Study"],"prefix":"10.4103","volume":"28","author":[{"given":"LiMan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Suizhou Hospital, Hubei University of Medicine (Suizhou Central Hospital), Suizhou, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WeiWei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Suizhou Hospital, Hubei University of Medicine (Suizhou Central Hospital), Suizhou, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HengCui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Suizhou Hospital, Hubei University of Medicine (Suizhou Central Hospital), Suizhou, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HaiXia","family":"Jie","sequence":"additional","affiliation":[{"name":"Nursing Department, Suizhou Hospital, Hubei University of Medicine (Suizhou Central Hospital), Suizhou, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,28]]},"reference":[{"key":"R1-20260326","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1186\/cc12870","article-title":"An investigation of sound levels on intensive care units with reference to the WHO guidelines","volume":"17","author":"Darbyshire","year":"2013","journal-title":"Crit Care"},{"key":"R2-20260326","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1378\/chest.114.2.535","article-title":"Identification and modification of environmental noise in an ICU setting","volume":"114","author":"Kahn","year":"1998","journal-title":"Chest"},{"issue":"e","key":"R3-20260326","doi-asserted-by":"crossref","first-page":"17083","DOI":"10.1111\/gcb.17083","article-title":"Cognition as a neglected mediator of responses to anthropogenic noise","volume":"30","author":"Grunst","year":"2024","journal-title":"Glob Chang Biol"},{"key":"R4-20260326","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/19338244.2023.2174927","article-title":"The relationship between noise-induced hearing loss and cognitive function","volume":"78","author":"Rahimian","year":"2023","journal-title":"Arch Environ Occup Health"},{"key":"R5-20260326","doi-asserted-by":"crossref","first-page":"108012","DOI":"10.1016\/j.heares.2020.108012","article-title":"Interaction of auditory and pain pathways: Effects of stimulus intensity, hearing loss and opioid signaling","volume":"393","author":"Manohar","year":"2020","journal-title":"Hear Res"},{"key":"R6-20260326","first-page":"81","article-title":"Assessment of coma and impaired consciousness","volume":"2","author":"Teasdale","year":"1974","journal-title":"A practical scale. 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