{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:28Z","timestamp":1787840548052,"version":"build-2784847793"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"122","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aimed to explore the mechanism by which noise contributes to the development of Alzheimer\u2019s disease (AD)\u2013like lesions.\n                    <jats:bold>Method:<\/jats:bold>\n                    Male Wistar rats (24 months) were allocated into two groups (\n                    <jats:italic toggle=\"yes\">n<\/jats:italic>\n                    \u2009=\u20096 per groups): a noise group exposed to 98\u2009dB sound pressure\u2013level white noise for 4 hours daily from 8:00 to 12:00 for 30 days, and a control group without noise exposure. The cognitive functions of the rats were assessed using new-object recognition and Morris water maze tests. Then, hippocampal tissues were collected, and the levels of amyloid \u03b2 1-42 (A\u03b21-42), A\u03b21-40, brain-derived neurotrophic factor (BDNF), and tropomyosin receptor kinase B (TrkB) were measured using enzyme-linked immunosorbent assay (ELISA). Protein expression was evaluated through Western blot.\n                    <jats:bold>Results:<\/jats:bold>\n                    Noise exposure significantly impaired cognitive and recognition abilities, increased the escape latency, and decreased the number of crossings through the platform quadrant intersection and the time spent in the target quadrant (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.01). The new-object exploration and recognition index of the rats in the noise group markedly decreased (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.01). ELISA results indicated increases in A\u03b21-40 and A\u03b21-42 levels and decreases in BDNF and TrkB levels in the rat hippocampus in the noise group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.01). Western blot analyses revealed that beta-site amyloid precursor protein (APP) cleaving enzyme 1, phosphorylated tau protein, gamma-H2A histone family, member X, checkpoint kinase 2, p53, and p21 were remarkably elevated in the noise group (\n                    <jats:italic toggle=\"yes\">P<\/jats:italic>\n                    &lt; 0.01).\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Chronic noise exposure can cause hippocampal genetic damage in aged rats, leading to cognitive disorders and the development of lesions similar to those observed in AD. Thus, noise is a potential risk factor for neurodegenerative disorders.\n                  <\/jats:p>","DOI":"10.4103\/nah.nah_26_24","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:00:50Z","timestamp":1727679650000},"page":"287-293","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Noise Exposure Promotes Alzheimer\u2019s Disease\u2013Like Lesions and DNA Damage"],"prefix":"10.4103","volume":"26","author":[{"given":"Xiao-jie","family":"Dai","sequence":"first","affiliation":[{"name":"Internal Medicine-Neurology, Xi\u2019an Gaoxin Hospital, Shaanxi 710075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-hua","family":"Liao","sequence":"additional","affiliation":[{"name":"Guangzhou Yujia Biotechnology Co. Ltd, Guangzhou 510300, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Jia","sequence":"additional","affiliation":[{"name":"Internal Medicine-Neurology, Xi\u2019an Gaoxin Hospital, Shaanxi 710075, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Cao","sequence":"additional","affiliation":[{"name":"Internal Medicine-Neurology, Qingyang People\u2019s Hospital, Qingyang, Gansu 745000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-ning","family":"Zhou","sequence":"additional","affiliation":[{"name":"The Third Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi 710068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"R1-20241226","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1121\/10.0017002","article-title":"Noise-induced hearing disorders: clinical and investigational tools","volume":"153","author":"Le Prell","year":"2023","journal-title":"J Acoust Soc Am"},{"key":"R2-20241226","doi-asserted-by":"crossref","first-page":"e0270031","DOI":"10.1371\/journal.pone.0270031","article-title":"Music listening and stress recovery in healthy individuals: a systematic review with meta-analysis of experimental studies","volume":"17","author":"Adiasto","year":"2022","journal-title":"PLoS One"},{"key":"R3-20241226","first-page":"1","article-title":"Factors and effects of work-related stress and burnout on the well-being of social workers in the Eastern Cape province","volume":"2019","author":"Kheswa","year":"2019","journal-title":"South Africa. 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