{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:10:35Z","timestamp":1788887435211,"version":"build-2803163510"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"133","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"\n Objective:<\/jats:bold>\n This study aimed to evaluate the protective efficacy and molecular mechanisms of hydrogen (H\n 2<\/jats:sub>\n ) against noise-induced damage across the peripheral and central auditory systems.\n Materials and Methods:<\/jats:bold>\n Mice were exposed to noise with or without H\n 2<\/jats:sub>\n treatment. Auditory function was assessed using the auditory brainstem response (ABR) and distortion product otoacoustic emission (DPOAE). Cochlear morphological changes were examined using a scanning electron microscope. Central effects in the inferior colliculus (IC) were evaluated using hematoxylin and eosin staining, transmission electron microscopy, and proteomic analysis. Behavioral changes were measured by using prepulse inhibition (PPI) and shuttle-box tasks.\n Results:<\/jats:bold>\n H\n 2<\/jats:sub>\n significantly attenuated noise-induced ABR threshold shifts (\n P<\/jats:italic>\n < 0.05) and preserved wave I amplitudes at 80\u2009dB (2.69\u2009\u00b1\u20090.40 vs. 3.57\u2009\u00b1\u20090.15\u2009\u03bcV,\n P<\/jats:italic>\n < 0.05). H\n 2<\/jats:sub>\n attenuated noise-induced reduction of DPOAE (16\u2009kHz: 34.40\u2009\u00b1\u20092.70 vs. 24.67\u2009\u00b1\u20094.35,\n P<\/jats:italic>\n < 0.05) and mitigated outer hair cell (OHC) loss (survival: 89.92%\u2009\u00b1\u20091.23% vs. 82.10%\u2009\u00b1\u20091.6%, all\n P<\/jats:italic>\n < 0.05). In the IC, H\n 2<\/jats:sub>\n reduced neuronal pyknosis by 12.6% (\n P<\/jats:italic>\n < 0.05) and preserved the synaptic ultrastructure. Behaviorally, H\n 2<\/jats:sub>\n suppressed the noise-induced elevation of PPI at 75 and 80\u2009dB (75\u2009dB: 40.87%\u2009\u00b1\u20096.32% vs. 58.04%\u2009\u00b1\u20092.47%; 80\u2009dB: 50.01%\u2009\u00b1\u20093.14% vs. 58.04%\u2009\u00b1\u20092.47%, all\n P<\/jats:italic>\n < 0.05) and improved performance on the shuttle-box test. Proteomic analysis revealed that H\n 2<\/jats:sub>\n upregulated nicotinamide adenine dinucleotide phosphate hydrogen regeneration-related proteins (e.g., Tigar) and GABAergic synaptic proteins (e.g., Gad1) in the IC.\n Conclusion:<\/jats:bold>\n H\n 2<\/jats:sub>\n exerts a comprehensive neuroprotective effect against noise-induced damage, spanning from OHCs to central synaptic remodeling. This cognitive protection may be mediated by enhancing the antioxidant capacity and restoring the excitation\n \u2013<\/jats:bold>\n inhibition balance in the IC.\n <\/jats:p>","DOI":"10.4103\/nah.nah_30_26","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T10:04:24Z","timestamp":1788343464000},"page":"959-971","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects of Molecular Hydrogen on Noise-Induced Auditory and Cognitive Dysfunction"],"prefix":"10.4103","volume":"28","author":[{"given":"Lei","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, The Six Medical Center of Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China"},{"name":"State Key Laboratory of Hearing and Balance Science, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, The Six Medical Center of Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China"},{"name":"State Key Laboratory of Hearing and Balance Science, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, The Six Medical Center of Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China"},{"name":"State Key Laboratory of Hearing and Balance Science, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ShiMing","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Head and Neck Surgery, The Six Medical Center of Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China"},{"name":"State Key Laboratory of Hearing and Balance Science, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"R1-20260908","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/ajim.20223","article-title":"The global burden of occupational noise-induced hearing loss","volume":"48","author":"Nelson","year":"2005","journal-title":"Am J Ind Med"},{"key":"R2-20260908","doi-asserted-by":"crossref","first-page":"2402949","DOI":"10.1080\/07853890.2024.2402949","article-title":"Transcriptional profile changes caused by noise-induced tinnitus in the cochlear nucleus and inferior 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