{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T04:11:33Z","timestamp":1793765493776,"version":"4.6.1"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"112","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Adolescents may be at risk of noise-induced hearing loss due to recreational sound. The aim of this study was to examine the role of distortion product otoacoustic emissions (DPOAEs) in screening for early stages of high-frequency loss such as can be observed in noise-induced hearing loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting and design:<\/jats:title>\n                    <jats:p>This cross-sectional study was embedded within Generation R, an ongoing prospective birth cohort study in Rotterdam, The Netherlands. Data were collected from April 2016 to September 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 3456 adolescents with a mean age of 13 years and 8 months old (standard deviation\u2009\u00b1\u20095 months) were included. Pure-tone thresholds were measured in a sound-treated booth. DPOAEs were recorded using an ILO V6 analyzer with primary levels of 65\/55\u2009dB SPL and frequency ratio\n                      <jats:italic toggle=\"yes\">f<\/jats:italic>\n                      <jats:sub>2<\/jats:sub>\n                      \/\n                      <jats:italic toggle=\"yes\">f<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      of 1.22. Subjects had normal middle ear function at the time of assessment, based on tympanometry results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Measurements in 6065 ears showed that DPOAE levels tend to decrease with increasing pure-tone thresholds. However, the intersubject variability of DPOAE levels in ears with the same threshold was large. DPOAE levels could reasonably identify early stages of high-frequency hearing loss.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings of present study indicate that DPOAE measurements can potentially be used for adolescents hearing screening in the high frequencies. Future research is needed to optimize test performance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/nah.nah_38_21","type":"journal-article","created":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T02:07:04Z","timestamp":1725761224000},"page":"20-26","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Distortion Product Otoacoustic Emissions in Screening for Early Stages of High-frequency Hearing Loss in Adolescents"],"prefix":"10.4103","volume":"24","author":[{"given":"Danique E.","family":"Paping","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"van der Schroef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiske 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