{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:22:05Z","timestamp":1793733725794,"version":"4.6.1"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"121","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4]]},"abstract":"\n Context:<\/jats:bold>\n Presbycusis can be mediated by the effects of inflammatory processes on the auditory system, and these aging biological mechanisms remain poorly studied.\n Aims:<\/jats:bold>\n The aim of this study was to determine whether plasma biomarkers are associated with hearing disorders caused by aging in the elderly.\n Settings and design:<\/jats:bold>\n Cross-sectional study with 106 participants in the Active Aging Project, 93 (88%) females and 13 (12%) males, with an average age of 70 years.\n Methods and material:<\/jats:bold>\n Audiological evaluation was performed with pure tone audiometry and collection of peripheral blood for the measurement of plasma levels of interleukins 2, 4, 6, and 10, tumor necrosis factor-\u03b1, and interferon-\u03b3 by means of flow cytometry.\n Statistical analysis used:<\/jats:bold>\n The SPSS (v.0, SPSS Inc., Chicago, USA) was used for the analysis of the data obtained. For all data analyzed, the significance level adopted was\n P<\/jats:italic>\n < 0.05 and 95% confidence interval.\n Results:<\/jats:bold>\n There were statistically significant correlations between male and IL-2 (\n P<\/jats:italic>\n \u2009=\u20090.031; rs\u2009=\u20090.210), mean II of the right ear (\n P<\/jats:italic>\n \u2009=\u20090.004; rs\u2009=\u20090.279), longer in years (\n P<\/jats:italic>\n \u2009=\u20090.002; rs\u2009=\u20090.307) and in hours (\n P<\/jats:italic>\n \u2009=\u20090.004; rs\u2009=\u20090.281) of noise exposure also in males.\n Conclusions:<\/jats:bold>\n In the present study, there was an association between the male gender and higher plasma levels of IL-2, an increase in the average hearing in the right ear, and greater time in years and hours of exposure to noise. There was a predominance of mild sensorineural hearing loss and worsening of hearing related to age, characteristics of presbycusis.\n <\/jats:p>","DOI":"10.4103\/nah.nah_3_23","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T12:09:14Z","timestamp":1718885354000},"page":"165-173","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Plasma Levels of Interleukin 2 (IL-2) Associated with Hearing Loss Evaluation in the Elderly"],"prefix":"10.4103","volume":"26","author":[{"given":"Fernanda P.","family":"Cordeiro","sequence":"first","affiliation":[{"name":"Student of theMaster\u2019s and Doctor\u2019s Degree in Rehabilitation Sciences, UEL-UNOPAR. https:\/\/orcid.org\/0000-0003-4489-2568"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana L.M.","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Interdisciplinary Laboratory for Intervention in Health Promotion LIIPS\/UNICESUMAR-Maring\u00e1, Paran\u00e1, Brazil https:\/\/orcid.org\/0000-0002-9026-0468"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denilson C.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Research Center in Health Science, State University of Londrina, Paran\u00e1, Brazil https:\/\/orcid.org\/0000-0002-6299-0252"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo A.C.","family":"Andraus","sequence":"additional","affiliation":[{"name":"Professor of the Master\u2019s and Doctor\u2019s Degree Associated in Rehabilitation Sciences UEL-UNOPAR https:\/\/orcid.org\/0000-0002-3849-0872"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina C\u00e9lia","family":"Poli-Frederico","sequence":"additional","affiliation":[{"name":"Professor of the Master\u2019s and Doctor\u2019s Degree Associated in Rehabilitation Sciences UEL-UNOPAR. https:\/\/orcid.org\/0000-0003-4631-4606"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"R1-20240908","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00405-019-05689-x","article-title":"Quantitative criteria for age-related hearing loss using audiometric configuration analysis","volume":"277","author":"Lee","year":"2020","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"R2-20240908","year":"2014"},{"key":"R4-20240908","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1002\/jnr.24549","article-title":"Genetics of age-related hearing loss","volume":"98","author":"Wells","year":"2020","journal-title":"J Neurosci Res"},{"key":"R5-20240908","doi-asserted-by":"crossref","first-page":"e019615","DOI":"10.1136\/bmjopen-2017-019615","article-title":"Socioeconomic differences in hearing among middle-aged and older adults: cross-sectional analyses using the health survey for England","volume":"8","author":"Scholes","year":"2018","journal-title":"BMJ Open"},{"key":"R6-20240908","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3390\/jcm9010218","article-title":"Presbycusis: an update on cochlear mechanisms and therapies","volume":"9","author":"Wang","year":"2020","journal-title":"J Clin Med"},{"key":"R7-20240908","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12979-014-0018-4","article-title":"The association between hearing impairment and polymorphisms of genes encoding inflammatory mediators in Japanese aged population","volume":"11","author":"Uchida","year":"2014","journal-title":"Immun Ageing"},{"key":"R8-20240908","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.3390\/ijerph17072393","article-title":"A specific inflammatory profile underlying suicide risk? 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