{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:25:47Z","timestamp":1787207147609,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>For stroke treatment and rehabilitation, various types of medicine and therapies are available; however, they need to evolve continuously through evidence-based research. The present study analyzed clinical trials on stroke in India, registered at the Clinical Trials Registry of India (CTRI) to delineate the trends, advances, gaps, and challenges on stroke from clinical perspectives. The study analyzes randomized clinical trials (RCTs) on stroke, registered at the CTRI database, since the inception of CTRI (2007) till July 2025. Search was done using the keywords \u201cstroke,\u201d \u201cBrain attack,\u201d and \u201ccerebrovascular accident\u201d in the fields \u201cScientific Title,\u201d \u201cPublic Title,\u201d and \u201cHealth conditions.\u201d A total of 2102 trials related to stroke were retrieved from the CTRI database that reduces to 1109 after removing duplicates. Out of these, only 578 trials were interventional RCTs, and 560 trials were being conducted in India. The study revealed: (i) major contribution of the private sector, (ii) more public hospitals involved in the multicentric\/multi-intervention RCT, (iii) disparity in RCTs across states, (iv) maximum (62%) of studies were of satisfactory quality as per modified Jaded scale, (v) public hospitals performed slightly better in terms of quality parameters and sample size, and (vi) physiotherapy dominated among types of interventions being tested. Representation of the population of all states is necessary so that strategies may be developed on regional basis. Prioritizing stroke-prevalent regions for clinical trial activities can bridge critical gaps in public health outreach and empower local communities. Participation of government institutes and sponsorship must be increased, and collaboration should be encouraged.<\/jats:p>","DOI":"10.4103\/neurol-india.neurol-india-d-26-00401","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:00:28Z","timestamp":1787205628000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Stroke Clinical Trials in India: Bridging the Gaps in Public Health Outreach"],"prefix":"10.4103","author":[{"given":"Ray","family":"Suman","sequence":"first","affiliation":[{"name":"CSIR-National Institute for Science Communication and Policy Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maan","family":"Pratibha","sequence":"additional","affiliation":[{"name":"CSIR-National Institute for Science Communication and Policy Research, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chavan","family":"Chandrashekhar","sequence":"additional","affiliation":[{"name":"CSIR-National Institute for Science Communication and Policy Research, New Delhi, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"R1-20260820","doi-asserted-by":"crossref","first-page":"22640","DOI":"10.1038\/s41598-024-72551-4","article-title":"Analyzing stroke burden and risk factors in India using data from the global burden of disease study","volume":"14","author":"Behera","year":"2024","journal-title":"Sci Rep"},{"key":"R2-20260820","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1161\/CIRCULATIONAHA.107.743237","article-title":"Stroke: Indian scenario","volume":"118","author":"Das","year":"2008","journal-title":"Circulation"},{"key":"R3-20260820","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000525822","article-title":"Treatments in ischemic stroke: Current and future","volume":"85","author":"Mosconi","year":"2022","journal-title":"Eur Neurol"},{"key":"R4-20260820","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1016\/S0140-6736(24)00642-1","article-title":"Stroke","volume":"403","author":"Hilkens","year":"2024","journal-title":"Lancet"},{"key":"R5-20260820","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.3390\/ijms21207609","article-title":"Pathophysiology and treatment of stroke: Present status and future perspectives","volume":"21","author":"Kuriakose","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R6-20260820","doi-asserted-by":"crossref","first-page":"1561688","DOI":"10.3389\/fphar.2025.1561688","article-title":"Traditional, complementary, and integrative medicine in the management of ischemic stroke: A narrative review","volume":"16","author":"Sowmiya","year":"2025","journal-title":"Front Pharmacol"},{"key":"R7-20260820","doi-asserted-by":"crossref","first-page":"e0000617","DOI":"10.1371\/journal.pgph.0000617","article-title":"An analysis of deficiencies in the ethics committee data of certain interventional trials registered with the Clinical Trials Registry-India","volume":"2","author":"Chakraborty","year":"2022","journal-title":"PLOS Glob Public Health"},{"key":"R8-20260820","doi-asserted-by":"crossref","first-page":"100631","DOI":"10.1016\/j.jaim.2022.100631","article-title":"A methodological analysis of CTRI registered clinical trials on ayurveda interventions for COVID-19 management","volume":"14","author":"Chaudhari","year":"2023","journal-title":"J Ayurveda Integr Med"},{"key":"R10-20260820","doi-asserted-by":"crossref","first-page":"863","DOI":"10.4103\/jfmpc.jfmpc_2257_22","article-title":"Multi-centric clinic trials in evidence-based research-A narrative review on the Indian scenario","volume":"12","author":"Patil","year":"2023","journal-title":"J Family Med Prim Care"},{"key":"R11-20260820","doi-asserted-by":"crossref","first-page":"e574","DOI":"10.1161\/STROKEAHA.120.033149","article-title":"INSTRuCT: Protocol, infrastructure, and governance","volume":"52","author":"Pandian","year":"2021","journal-title":"Stroke"},{"key":"R12-20260820","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4103\/2229-3485.215970","article-title":"Do clinical trials conducted in India match its healthcare needs? An audit of the clinical trials registry of India","volume":"8","author":"Chaturvedi","year":"2017","journal-title":"Perspect Clin Res"},{"key":"R13-20260820","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s40141-023-00418-2","article-title":"WHO systematic assessment of rehabilitation situation (STARS): A systematic review on the status of stroke rehabilitation in India","volume":"11","author":"Handa","year":"2023","journal-title":"Curr Phys Med Rehabil Rep"},{"key":"R14-20260820","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1186\/s13063-019-3592-0","article-title":"An analysis of deficiencies in the data of interventional drug trials registered with clinical trials registry-India","volume":"20","author":"Pillamarapu","year":"2019","journal-title":"Trials"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/neurol-india.Neurol-India-D-26-00401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T06:00:30Z","timestamp":1787205630000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/neurol-india.Neurol-India-D-26-00401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,19]]},"references-count":13,"URL":"https:\/\/doi.org\/10.4103\/neurol-india.neurol-india-d-26-00401","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,19]]},"assertion":[{"value":"2026-04-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-07","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}