{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:18Z","timestamp":1786650078132,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Stents are increasingly used for coiling difficult aneurysms, to reduce the risk of recurrences, or to modify blood flow. Currently, available bifurcation aneurysm models are ill-suited to assess stent performance before clinical use. We designed a new animal model of wide-neck canine Y-type bifurcation aneurysm (such as middle cerebral artery (MCA) bifurcation) and previously reported one of T-type (such as basilar bifurcation). Its potential value as a training tool as well as in the evaluation of new techniques or stent or embolic agents was assessed. Seven canine aneurysms were created (three: Y-type, four: T-type). Aneurysms were followed by transfemoral cerebral angiography (TFCA) and computed tomography angiography (CTA). We performed TFCA and self-expandable stent placement for the parent artery adjoined to the aneurysmal neck in one month\u2019s follow-up. We assessed the long-term patency of the parent artery with CTA and euthanasia and got a specimen for pathologic study at six months\u2019 follow-up. In six models except one (T-type), a wide-neck bifurcation aneurysm was created successfully and they showed good long-term patency at six months\u2019 follow-up. Stent placement was technically difficult in these cases, but did not lead to aneurysm thrombosis in CTA or neointimal closure of the aneurysm neck in pathologic finding at postoperative six months later. This model may be suitable for studying the effects of endovascular treatment on aneurysm and branch occlusion rates, for preclinical testing of stents and other intravascular devices, and for training students in endovascular technique.<\/jats:p>","DOI":"10.4103\/ni.ni_1002_22","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T04:03:13Z","timestamp":1734494593000},"page":"1241-1245","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Surgical Construction of Wide-Neck Bifurcation Experimental Aneurysm in an In Vivo Canine Model to Test Neurovascular Device"],"prefix":"10.4103","volume":"72","author":[{"given":"Kuhyun","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Gangneung Asan Medical Center, University of Ulsan College of Medicine, Gangneung, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Bum","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Gangneung Asan Medical Center, University of Ulsan College of Medicine, Gangneung, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong Sub","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine and Public Health, University of Catholic Kwandong College of Medicine, Gangneung, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(05)67214-5","article-title":"International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: A randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion","volume":"366","author":"Molyneux","year":"2005","journal-title":"Lancet"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: A randomised trial","volume":"360","author":"Molyneux","year":"2002","journal-title":"Lancet"},{"key":"R3-20260424","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3174\/ajnr.A0902","article-title":"Mechanisms of occlusion and recanalization in canine carotid bifurcation aneurysms embolized with platinum coils: An alternative concept","volume":"29","author":"Raymond","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"R4-20260424","doi-asserted-by":"crossref","first-page":"418","DOI":"10.3174\/ajnr.A1853","article-title":"In vivo experimental intracranial aneurysm models: A systematic review","volume":"31","author":"Bouzeghrane","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"R5-20260424","first-page":"139","article-title":"Long-term patency of elastase-induced aneurysm model in rabbits","volume":"27","author":"Ding","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"R6-20260424","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.3174\/ajnr.A2056","article-title":"Five-year follow-up in elastase-induced aneurysms in rabbits","volume":"31","author":"Ding","year":"2010","journal-title":"AJNR Am J Neuroradiol"},{"key":"R7-20260424","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3171\/jns.1996.85.3.0488","article-title":"Microsurgically produced bifurcation aneurysms in a rabbit model for endovascular coil embolization","volume":"85","author":"Spetzger","year":"1996","journal-title":"J Neurosurg"},{"key":"R8-20260424","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/BF00593518","article-title":"Experimental saccular aneurysms. 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