{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:41:21Z","timestamp":1786650081366,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>Sporadic late-onset nemaline rod myopathy is a rare, acquired, sub-acute, adult-onset myopathy characterized by proximal muscle weakness and nemaline rods in the myofibers. In contrast to its congenital form, the prevalence in adult population is comparatively rare. Herein, we report a case of 60-year-old male who presented with insidious onset proximal muscle weakness with myopathic pattern on electromyography. Histopathological examination showed type 1 and 2 muscle fiber atrophy with minimal chronic inflammatory cell infiltrate. Modified Gomori trichrome staining revealed granular deposits in the myofibers. Ultrastructure examination showed numerous nemaline rods in the myofibers; hence, the diagnosis of sporadic late-onset nemaline myopathy was rendered. Its association with monoclonal protein has been reported in the past. One should be aware of this rare entity as without correct diagnosis, there can be treatment failure and unfavorable outcome.<\/jats:p>","DOI":"10.4103\/ni.ni_1008_21","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T04:00:55Z","timestamp":1734494455000},"page":"1270-1272","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Sporadic Late-Onset Nemaline Rod Myopathy: An Interesting Case"],"prefix":"10.4103","volume":"72","author":[{"given":"Anubhav","family":"Narwal","sequence":"first","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohit","family":"Mann","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achal K","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Neurology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehar C","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1093\/brain\/86.4.793","article-title":"Nemaline myopathy: A new congenital myopathy","volume":"86","author":"Shy","year":"1963","journal-title":"Brain"},{"key":"R2-20260424","first-page":"983","article-title":"Light and electron microscopic studies of \u201cmyogranules\u201d in a child with hypotonia and muscle weakness","volume":"89","author":"Conen","year":"1963","journal-title":"Can Med Assoc J"},{"key":"R4-20260424","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/01.wnl.0000180362.90078.dc","article-title":"Sporadic late onset nemaline myopathy","volume":"65","author":"Chahin","year":"2005","journal-title":"Neurology"},{"key":"R5-20260424","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ana.1080","article-title":"Nemaline myopathy: A clinical study of 143 cases","volume":"50","author":"Ryan","year":"2001","journal-title":"Ann Neurol"},{"key":"R6-20260424","doi-asserted-by":"crossref","first-page":"86.","DOI":"10.1186\/s13023-017-0640-2","article-title":"Sporadic late-onset nemaline myopathy: Clinico-pathological characteristics and review of 76 cases","volume":"12","author":"Schnitzler","year":"2017","journal-title":"Orphanet J Rare Dis"},{"key":"R7-20260424","doi-asserted-by":"crossref","first-page":"e298","DOI":"10.1212\/WNL.0000000000007777","article-title":"Sporadic late-onset nemaline myopathy: Clinical spectrum, survival, and treatment outcomes","volume":"93","author":"Naddaf","year":"2019","journal-title":"Neurology"},{"key":"R8-20260424","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood-2006-03-001164","article-title":"Dangerous small B-cell clones","volume":"108","author":"Merlini","year":"2006","journal-title":"Blood"},{"key":"R9-20260424","doi-asserted-by":"crossref","first-page":"440.","DOI":"10.1001\/archneur.1992.00530290022003","article-title":"Progressive nemaline (rod) myopathy as a presentation of human immunodeficiency virus infection","volume":"49","author":"Dwyer","year":"1992","journal-title":"Arch Neurol"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ni.ni_1008_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:01:53Z","timestamp":1786647713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ni.ni_1008_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ni.ni_1008_21","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"2021-09-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}