{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:20:25Z","timestamp":1787772025056,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Migraine is the most common primary headache in children. Neuromediators and deterioration in circadian rhythm and sleep disorders can play a role in the etiology of migraines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>To determine the serum melatonin levels of children with migraine and the relationship between melatonin and childhood migraine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Thirty-five children aged between 10 and 18 years with migraine as the case group and 35 healthy children of similar age and sex as the control group were included in the study. Venous blood samples were taken at 09.00 AM and melatonin analysis was performed using enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean serum melatonin levels of the case group and control group were found to be 300.1 \u00b1 67.3 pg\/mL and 314.9 \u00b1 64.0 pg\/mL, respectively. There was no statistically significant difference between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.351). Comparison of the melatonin levels in the case group according to the clinical characteristics was not significantly different.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>An association between sleep and migraine is predictable, but its pathophysiology is not yet known. Etiological studies continue and the relationship between melatonin and migraine remains unclear.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ni.ni_1108_21","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T21:01:02Z","timestamp":1709672462000},"page":"74-77","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Melatonin Levels in Children with Migraine"],"prefix":"10.4103","volume":"72","author":[{"given":"Tahir","family":"Ayd\u0131n","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Haseki Education and Training Hospital, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senem","family":"Ay\u00e7a","sequence":"additional","affiliation":[{"name":"Department of Pediatric Neurology, Haseki Education and Training Hospital, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamer","family":"Yurdakul","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Haseki Education and Training Hospital, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Elevli","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Haseki Education and Training Hospital, \u0130stanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,29]]},"reference":[{"key":"R1-20240907","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1177\/0333102409355601","article-title":"Migraine prevalence by age and sex in the United States: a life-span 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report","volume":"29","author":"Claustrat","year":"1989","journal-title":"Headache"},{"key":"R5-20240907","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s13760-016-0723-1","article-title":"Sleep quality, morningness\u2013eveningness preference, mood profile, and levels of serum melatonin in migraine patients: A case\u2013control study","volume":"117","author":"Kozak","year":"2017","journal-title":"Acta Neurol Belg"},{"key":"R6-20240907","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1177\/0883073813502394","article-title":"Urinary 6-sulphatoxymelatonin levels and sleep disorders in children with migraine","volume":"29","author":"Abou-Khadra","year":"2014","journal-title":"J Child Neurol"},{"key":"R7-20240907","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1111\/head.13547","article-title":"Preliminary evidence that melatonin \u0131s not a biomarker in children and adolescents with episodic 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in migraine prophylaxis of children","volume":"12","author":"Fallah","year":"2018","journal-title":"Iran J Child Neurol"}],"container-title":["Neurology India"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ni.ni_1108_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:24:27Z","timestamp":1787768667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ni.ni_1108_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ni.ni_1108_21","relation":{},"ISSN":["0028-3886","1998-4022"],"issn-type":[{"value":"0028-3886","type":"print"},{"value":"1998-4022","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2021-10-15","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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