{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:38:45Z","timestamp":1786653525008,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>This study aimed to report our experiences with the safety and reliability of frameless stereotactic brain biopsy, including eloquent areas and small-sized lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We reviewed 88 consecutive cases of brain lesions diagnosed with neuronavigation-guided frameless stereotactic biopsy in two different neurosurgical institutes (Turkey and Germany). In addition to a standard technique, magnetic resonance imaging (MRI)\u2013computed tomography (CT) fusion images were used to enhance the accuracy of targeting. To stabilize the navigation system on the target, the deviation from average accuracy was set at 1 mm with MRI alone. The deviation from average accuracy was 0.5 mm on fused MRI-CT images.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were 43 males and 45 females with a mean age of 62 years. The lesion diameter was \u22642 cm in 24 patients and &gt;2 cm in 64 patients. The lesion was in the eloquent region in 16 patients. Histopathological diagnostic success rate was 98.8%. Overall, 56, 21, 5, and 3 patients were diagnosed with glial tumor, lymphoma, abscess, and metastasis, respectively, and 1 patient each with acute myeloid leukemia, radiation necrosis, and nonneoplastic neuroglial tissue was observed as a pathological result.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The frameless biopsy system is gaining popularity because it is reliable and has a low complication rate. It provides rapid and accurate pathological results even for deeply located or small (size \u22642 cm) lesions. The frameless biopsy systems were used safely with a very high diagnostic accuracy rate according to the learning curve.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ni.ni_1344_21","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T12:19:38Z","timestamp":1738930778000},"page":"82-87","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Reliability of Frameless Stereotactic Brain Biopsy for Complicated Lesions: Multicenter Experiences"],"prefix":"10.4103","volume":"73","author":[{"given":"Selcuk","family":"Gocmen","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Anadolu Medical Center-Johns Hopkins Medicine, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersin","family":"Haciyakupoglu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Heinrich- Braun-Klinikum, Zwickau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Acka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Anadolu Medical Center-Johns Hopkins Medicine, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleyka","family":"Aponte-Mendoza","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Heinrich- Braun-Klinikum, Zwickau, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onder","family":"Onguru","sequence":"additional","affiliation":[{"name":"Department of Pathology, Anadolu Medical Center-Johns Hopkins Medicine, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Tasci","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Anadolu Medical Center-Johns Hopkins Medicine, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serdar","family":"Kahraman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Anadolu Medical Center-Johns Hopkins Medicine, Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"R1-20250713","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1007\/s00701-015-2543-0","article-title":"Contemporary frameless intracranial biopsy techniques: Might variation in safety and efficacy be expected?","volume":"157","author":"Verploegh","year":"2015","journal-title":"Acta Neurochir"},{"key":"R2-20250713","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.clineuro.2018.09.020","article-title":"How is stereotactic brain biopsy evolving? A multicentric analysis of a series of 421 cases treated in Rome over the last sixteen years","volume":"174","author":"Callovini","year":"2018","journal-title":"Clin Neurol Neurosurg"},{"key":"R3-20250713","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1159\/000325704","article-title":"Frameless stereotactic cerebral biopsy: Our experience in 296 cases","volume":"89","author":"Frati","year":"2011","journal-title":"Stereotact Funct Neursurg"},{"key":"R4-20250713","doi-asserted-by":"crossref","first-page":"145","DOI":"10.14235\/bas.galenos.2018.1596","article-title":"Frameless neuronavigation assisted brain biopsy: Safety, efficiency and our experience","volume":"7","author":"Ozek","year":"2019","journal-title":"Bezmialem Sci"},{"key":"R5-20250713","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1227\/01.NEU.0000369190.46510.42","article-title":"Assessing accuracy of the magnetic resonance imaging-computed tomography fusion images to evaluate the electrode positions 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