{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:43:36Z","timestamp":1786653816473,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The purpose of the study is to establish the prevalence of stroke as well as the clinical and radiological correlates of stroke in children with tuberculous meningitis (TBM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Materials:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted at the Pediatric Department, King George\u2019s Medical University (KGMU), Lucknow, Uttar Pradesh, India. Using a computed tomography (CT) scan\/brain magnetic resonance imaging (MRI), patients were divided into stroke and non-stroke groups. Demographic characteristics, clinical presentations, cerebrospinal fluid examination, basal meningeal enhancement, hydrocephalus, tuberculoma, and clinical outcome were compared between the two groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Seventy-eight TBM patients, aged between 6 months and 14 years, were included. Out of 78 enrolled patients, 3 (3.8%) had definite TBM, 73 (91%) had probable TBM, and 4 (5.1%) had possible TBM (LCS). As per the Medical Research Council (MRC) staging, 13% had Stage 1 TBM, 26% had stage 2, and 61% had stage 3 TBM. Out of 78 patients with chest X-ray findings, 42 (53%) had findings suggestive of tuberculosis (TB), which included 33 (42%) with hilar lymphadenopathy and 9 (11%) with a miliary pattern. On neuroimaging, hydrocephalous was seen in 62.8% of cases, basal meningeal enhancement in 64.1%, tuberculoma in 6.4% of cases, and infarction in 53.8% of cases. There was no statistically significant association found between the staging of TBM and the presence of infarction as the majority of cases involved were in stage 3 of the disease (61.5%). TBM patients with stroke had poor clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Age, altered sensorium, focal neurological deficits, vomiting, and basal meningeal enhancement can predict the occurrence of stroke in young adults with TBM.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ni.ni_740_22","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T13:01:04Z","timestamp":1714568464000},"page":"368-374","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Risk Factors for Stroke in Children with Tuberculous Meningitis: A Prospective Observational Study"],"prefix":"10.4103","volume":"72","author":[{"given":"Niti","family":"Prakash","sequence":"first","affiliation":[{"name":"Department of Pediatrics, King George\u2019s Medical University, Lucknow, UP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, UP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandrakanta","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, King George\u2019s Medical University, Lucknow, UP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Microbiology, King George\u2019s Medical University, Lucknow, UP, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sukriti","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, King George\u2019s Medical University, Lucknow, UP, 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